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Article: Effect of a cardiac rehabilitation program on left ventricular diastolic function and its relationship to exercise capacity in patients with coronary heart disease: Experience from a randomized, controlled study

TitleEffect of a cardiac rehabilitation program on left ventricular diastolic function and its relationship to exercise capacity in patients with coronary heart disease: Experience from a randomized, controlled study
Authors
Issue Date2004
PublisherMosby, Inc. The Journal's web site is located at http://www.elsevier.com/locate/ahj
Citation
American Heart Journal, 2004, v. 147 n. 5, p. 874+11-18 How to Cite?
AbstractBackground A cardiac rehabilitation and prevention program (CRPP) is a recognized nonpharmacological modality in the management of coronary heart disease (CHD). However, the effect of a CRPP on systolic function of the heart is controversial, and no data exists on diastolic function in CHD. A randomized, controlled study was conducted to address these issues. Methods Patients (n = 269) with recent acute myocardial infarction (n = 193) or after percutaneous coronary intervention (PCI) (n = 76) were randomized to either CRPP (2-hour twice-weekly exercise program for 8 weeks) or conventional therapy (control group). Serial treadmill exercise testing and at-rest echocardiography were performed during phases 1 (baseline), 2 (post-exercise training), and 3 (8-month follow up). Results The prevalence of left ventricular (LV) abnormal relaxation pattern (ARP) of diastolic dysfunction was increased in the control group only in phase 3 (65% vs 88%, χ 2 = 7.6, P < .01). Significant improvement of individual LV diastolic parameters towards less severe delayed relaxation was also observed in the CRPP group, especially in those with recent acute myocardial infarction or ARP. The gain in exercise capacity was faster and more substantial in the CRPP than the control group (P < .001 for phase 2, P < .05 for phase 3), and was significantly correlated with LV diastolic indices in those with ARP. Exercise training had neutral effects on LV systolic function and rate-pressure product. Conclusions In patients with CHD, CRPP prevented the progression of resting LV diastolic dysfunction, without affecting systolic function. In those with ARP, the improvement of diastolic function predicted the gain in exercise capacity.
Persistent Identifierhttp://hdl.handle.net/10722/162932
ISSN
2015 Impact Factor: 4.332
2015 SCImago Journal Rankings: 3.157
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorYu, CMen_US
dc.contributor.authorLi, LSWen_US
dc.contributor.authorLam, MFen_US
dc.contributor.authorSiu, DCWen_US
dc.contributor.authorMiu, RKMen_US
dc.contributor.authorLau, CPen_US
dc.date.accessioned2012-09-05T05:25:30Z-
dc.date.available2012-09-05T05:25:30Z-
dc.date.issued2004en_US
dc.identifier.citationAmerican Heart Journal, 2004, v. 147 n. 5, p. 874+11-18en_US
dc.identifier.issn0002-8703en_US
dc.identifier.urihttp://hdl.handle.net/10722/162932-
dc.description.abstractBackground A cardiac rehabilitation and prevention program (CRPP) is a recognized nonpharmacological modality in the management of coronary heart disease (CHD). However, the effect of a CRPP on systolic function of the heart is controversial, and no data exists on diastolic function in CHD. A randomized, controlled study was conducted to address these issues. Methods Patients (n = 269) with recent acute myocardial infarction (n = 193) or after percutaneous coronary intervention (PCI) (n = 76) were randomized to either CRPP (2-hour twice-weekly exercise program for 8 weeks) or conventional therapy (control group). Serial treadmill exercise testing and at-rest echocardiography were performed during phases 1 (baseline), 2 (post-exercise training), and 3 (8-month follow up). Results The prevalence of left ventricular (LV) abnormal relaxation pattern (ARP) of diastolic dysfunction was increased in the control group only in phase 3 (65% vs 88%, χ 2 = 7.6, P < .01). Significant improvement of individual LV diastolic parameters towards less severe delayed relaxation was also observed in the CRPP group, especially in those with recent acute myocardial infarction or ARP. The gain in exercise capacity was faster and more substantial in the CRPP than the control group (P < .001 for phase 2, P < .05 for phase 3), and was significantly correlated with LV diastolic indices in those with ARP. Exercise training had neutral effects on LV systolic function and rate-pressure product. Conclusions In patients with CHD, CRPP prevented the progression of resting LV diastolic dysfunction, without affecting systolic function. In those with ARP, the improvement of diastolic function predicted the gain in exercise capacity.en_US
dc.languageengen_US
dc.publisherMosby, Inc. The Journal's web site is located at http://www.elsevier.com/locate/ahjen_US
dc.relation.ispartofAmerican Heart Journalen_US
dc.titleEffect of a cardiac rehabilitation program on left ventricular diastolic function and its relationship to exercise capacity in patients with coronary heart disease: Experience from a randomized, controlled studyen_US
dc.typeArticleen_US
dc.identifier.emailSiu, DCW:cwdsiu@hkucc.hku.hken_US
dc.identifier.authoritySiu, DCW=rp00534en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1016/j.ahj.2003.12.004en_US
dc.identifier.pmid15131559-
dc.identifier.scopuseid_2-s2.0-3042811604en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-3042811604&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume147en_US
dc.identifier.issue5en_US
dc.identifier.spage874+11en_US
dc.identifier.epage18en_US
dc.identifier.isiWOS:000221479100027-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridYu, CM=7404976646en_US
dc.identifier.scopusauthoridLi, LSW=7501450364en_US
dc.identifier.scopusauthoridLam, MF=7202630163en_US
dc.identifier.scopusauthoridSiu, DCW=7006550690en_US
dc.identifier.scopusauthoridMiu, RKM=7801613455en_US
dc.identifier.scopusauthoridLau, CP=35275317200en_US

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