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Article: Lung cancer susceptibility and polymorphisms of glutathione-S-transferase genes in Hong Kong

TitleLung cancer susceptibility and polymorphisms of glutathione-S-transferase genes in Hong Kong
Authors
KeywordsGlutathione-S-transferases
Lung cancer
Polymorphisms
Risk
Issue Date2004
PublisherElsevier Ireland Ltd. The Journal's web site is located at http://www.elsevier.com/locate/lungcan
Citation
Lung Cancer, 2004, v. 45 n. 2, p. 155-160 How to Cite?
AbstractObjective: To study the potential role of genetic polymorphisms of glutathione-S-transferases GSTM1, GSTT1 and GSTP1 in susceptibility to lung cancer in Hong Kong Chinese. Methods: 229 consecutive incident patients with a histological diagnosis of lung cancer from a regional hospital and 197 healthy population-based controls were recruited for this study between July 1999 and June 2001. Genetic polymorphisms of GSTT1 and GSTM1 were determined using PCR-based technique. Results: The frequencies of GSTT1 and GSTM1 null geneotypes were 51.8 and 59.4% in healthy controls and 63 and 54.7%, respectively, in lung cancer patients. GSTP1 Val105/Val105 genotype was found in only 1% of healthy controls. The risk for lung cancer with GSTT1 null genotype was significantly higher, adjusted odds ratio (OR) 1.69, 95% confidence interval (CI) 1.12-2.56, compared with those with the GSTT1 genotype; the increase in risk was found only in non-smokers. GSTM1 null genotype, combined GSTT1 and GSTM1 null genotype and GSTP1 Val105/Val105 genotype did not confer any increase risk for lung cancer. Conclusion: GSTT1 null genotype is associated with an increased risk for lung cancer in non-smoking Chinese in Hong Kong. © 2004 Elsevier Ireland Ltd. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/162931
ISSN
2015 Impact Factor: 3.767
2015 SCImago Journal Rankings: 1.923
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorChanYeung, Men_US
dc.contributor.authorTanUn, KCen_US
dc.contributor.authorIp, MSMen_US
dc.contributor.authorTsang, KWTen_US
dc.contributor.authorHo, SPen_US
dc.contributor.authorHo, JCMen_US
dc.contributor.authorChan, Hen_US
dc.contributor.authorLam, WKen_US
dc.date.accessioned2012-09-05T05:25:30Z-
dc.date.available2012-09-05T05:25:30Z-
dc.date.issued2004en_US
dc.identifier.citationLung Cancer, 2004, v. 45 n. 2, p. 155-160en_US
dc.identifier.issn0169-5002en_US
dc.identifier.urihttp://hdl.handle.net/10722/162931-
dc.description.abstractObjective: To study the potential role of genetic polymorphisms of glutathione-S-transferases GSTM1, GSTT1 and GSTP1 in susceptibility to lung cancer in Hong Kong Chinese. Methods: 229 consecutive incident patients with a histological diagnosis of lung cancer from a regional hospital and 197 healthy population-based controls were recruited for this study between July 1999 and June 2001. Genetic polymorphisms of GSTT1 and GSTM1 were determined using PCR-based technique. Results: The frequencies of GSTT1 and GSTM1 null geneotypes were 51.8 and 59.4% in healthy controls and 63 and 54.7%, respectively, in lung cancer patients. GSTP1 Val105/Val105 genotype was found in only 1% of healthy controls. The risk for lung cancer with GSTT1 null genotype was significantly higher, adjusted odds ratio (OR) 1.69, 95% confidence interval (CI) 1.12-2.56, compared with those with the GSTT1 genotype; the increase in risk was found only in non-smokers. GSTM1 null genotype, combined GSTT1 and GSTM1 null genotype and GSTP1 Val105/Val105 genotype did not confer any increase risk for lung cancer. Conclusion: GSTT1 null genotype is associated with an increased risk for lung cancer in non-smoking Chinese in Hong Kong. © 2004 Elsevier Ireland Ltd. All rights reserved.en_US
dc.languageengen_US
dc.publisherElsevier Ireland Ltd. The Journal's web site is located at http://www.elsevier.com/locate/lungcanen_US
dc.relation.ispartofLung Canceren_US
dc.rightsLung Cancer. Copyright © Elsevier Ireland Ltd.-
dc.subjectGlutathione-S-transferases-
dc.subjectLung cancer-
dc.subjectPolymorphisms-
dc.subjectRisk-
dc.subject.meshAdulten_US
dc.subject.meshAsian Continental Ancestry Group - Geneticsen_US
dc.subject.meshCase-Control Studiesen_US
dc.subject.meshConfidence Intervalsen_US
dc.subject.meshFemaleen_US
dc.subject.meshGenetic Predisposition To Diseaseen_US
dc.subject.meshGenotypeen_US
dc.subject.meshGlutathione Transferase - Geneticsen_US
dc.subject.meshHong Kong - Epidemiologyen_US
dc.subject.meshHumansen_US
dc.subject.meshIncidenceen_US
dc.subject.meshLogistic Modelsen_US
dc.subject.meshLung Neoplasms - Epidemiology - Geneticsen_US
dc.subject.meshMaleen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshOdds Ratioen_US
dc.subject.meshPolymorphism, Geneticen_US
dc.subject.meshProbabilityen_US
dc.subject.meshPrognosisen_US
dc.subject.meshRisk Assessmenten_US
dc.subject.meshSmoking - Adverse Effectsen_US
dc.titleLung cancer susceptibility and polymorphisms of glutathione-S-transferase genes in Hong Kongen_US
dc.typeArticleen_US
dc.identifier.emailTanUn, KC:kctanun@hkucc.hku.hken_US
dc.identifier.emailIp, MSM:msmip@hku.hken_US
dc.identifier.emailHo, JCM:jhocm@hku.hken_US
dc.identifier.authorityTanUn, KC=rp00787en_US
dc.identifier.authorityIp, MSM=rp00347en_US
dc.identifier.authorityHo, JCM=rp00258en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1016/j.lungcan.2004.01.016en_US
dc.identifier.pmid15246186en_US
dc.identifier.scopuseid_2-s2.0-3042800103en_US
dc.identifier.hkuros90063-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-3042800103&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume45en_US
dc.identifier.issue2en_US
dc.identifier.spage155en_US
dc.identifier.epage160en_US
dc.identifier.isiWOS:000222987700004-
dc.publisher.placeIrelanden_US
dc.identifier.scopusauthoridChanYeung, M=54790582200en_US
dc.identifier.scopusauthoridTanUn, KC=6602914262en_US
dc.identifier.scopusauthoridIp, MSM=7102423259en_US
dc.identifier.scopusauthoridTsang, KWT=24296730400en_US
dc.identifier.scopusauthoridHo, SP=12794365900en_US
dc.identifier.scopusauthoridHo, JCM=7402649981en_US
dc.identifier.scopusauthoridChan, H=8926625400en_US
dc.identifier.scopusauthoridLam, WK=7203021937en_US

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