File Download
  Links for fulltext
     (May Require Subscription)
Supplementary

Article: Hepatitis B virus genotype A and D clinical outcomes of liver transplantation for HBV-related disease

TitleHepatitis B virus genotype A and D clinical outcomes of liver transplantation for HBV-related disease
Authors
Issue Date2004
PublisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jtoc/106570021
Citation
Liver Transplantation, 2004, v. 10 n. 1, p. 58-64 How to Cite?
AbstractHepatitis B virus (HBV) genotypes have been associated with specific patterns of disease and response to antiviral therapy. We investigated the effect of HBV genotype on HBV recurrence and mortality after liver transplantation (LT). Pretransplant sera of 45 hepatitis B surface antigen (HBsAg) positive adults were submitted for HBV genotyping by a reverse-phase hybridization line probe assay with genotype-specific probes. Data were correlated with clinical outcomes after transplantation. Genotype A (n = 15), D (n = 13) and A/D (n = 12) accounted for 89% of all genotypes. Coinfection with two HBV genotypes was encountered in 14 (31.1%) patients. Eighteen patients (40 %) developed HBV recurrence at a median of 10 months posttransplant (range, 1-53) and 10 patients (22 %) died at a median of 24 months (range, 3-63). Genotype D patients were more likely to develop HBV recurrence or die compared with genotype A patients, although this did not reach statistical significance. Dual infection with genotype A/D resulted in mortality similar to that of genotype A but recurrence similar to that of genotype D. Active viral replication at time of transplantation was the only independent factor (P = 0.03) that predicted HBV recurrence. In conclusion, HBV genotype A and D did not have a significant impact on clinical outcomes of LT for HBV-related liver disease in patients of European origin. These data do not support routine HBV genotyping in liver transplantation. Copyright © 2004 by the American Association for the Study of Liver Diseases.
Persistent Identifierhttp://hdl.handle.net/10722/162930
ISSN
2015 Impact Factor: 3.951
2015 SCImago Journal Rankings: 1.763
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorGirlanda, Ren_US
dc.contributor.authorMohsen, AHen_US
dc.contributor.authorSmith, Hen_US
dc.contributor.authorSablon, Een_US
dc.contributor.authorYuen, MFen_US
dc.contributor.authorO'grady, Jen_US
dc.contributor.authorMuiesan, Pen_US
dc.contributor.authorRela, Men_US
dc.contributor.authorHeaton, Nen_US
dc.contributor.authorNorris, Sen_US
dc.date.accessioned2012-09-05T05:25:29Z-
dc.date.available2012-09-05T05:25:29Z-
dc.date.issued2004en_US
dc.identifier.citationLiver Transplantation, 2004, v. 10 n. 1, p. 58-64en_US
dc.identifier.issn1527-6465en_US
dc.identifier.urihttp://hdl.handle.net/10722/162930-
dc.description.abstractHepatitis B virus (HBV) genotypes have been associated with specific patterns of disease and response to antiviral therapy. We investigated the effect of HBV genotype on HBV recurrence and mortality after liver transplantation (LT). Pretransplant sera of 45 hepatitis B surface antigen (HBsAg) positive adults were submitted for HBV genotyping by a reverse-phase hybridization line probe assay with genotype-specific probes. Data were correlated with clinical outcomes after transplantation. Genotype A (n = 15), D (n = 13) and A/D (n = 12) accounted for 89% of all genotypes. Coinfection with two HBV genotypes was encountered in 14 (31.1%) patients. Eighteen patients (40 %) developed HBV recurrence at a median of 10 months posttransplant (range, 1-53) and 10 patients (22 %) died at a median of 24 months (range, 3-63). Genotype D patients were more likely to develop HBV recurrence or die compared with genotype A patients, although this did not reach statistical significance. Dual infection with genotype A/D resulted in mortality similar to that of genotype A but recurrence similar to that of genotype D. Active viral replication at time of transplantation was the only independent factor (P = 0.03) that predicted HBV recurrence. In conclusion, HBV genotype A and D did not have a significant impact on clinical outcomes of LT for HBV-related liver disease in patients of European origin. These data do not support routine HBV genotyping in liver transplantation. Copyright © 2004 by the American Association for the Study of Liver Diseases.en_US
dc.languageengen_US
dc.publisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jtoc/106570021en_US
dc.relation.ispartofLiver Transplantationen_US
dc.subject.meshAdolescenten_US
dc.subject.meshAdulten_US
dc.subject.meshAgeden_US
dc.subject.meshFemaleen_US
dc.subject.meshGenotypeen_US
dc.subject.meshGraft Survivalen_US
dc.subject.meshHepatitis B - Surgeryen_US
dc.subject.meshHepatitis B Virus - Geneticsen_US
dc.subject.meshHumansen_US
dc.subject.meshLiver Transplantationen_US
dc.subject.meshLogistic Modelsen_US
dc.subject.meshMaleen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshRecurrenceen_US
dc.subject.meshVirus Replicationen_US
dc.titleHepatitis B virus genotype A and D clinical outcomes of liver transplantation for HBV-related diseaseen_US
dc.typeArticleen_US
dc.identifier.emailYuen, MF:mfyuen@hkucc.hku.hken_US
dc.identifier.authorityYuen, MF=rp00479en_US
dc.description.naturelink_to_OA_fulltexten_US
dc.identifier.doi10.1002/lt.20004en_US
dc.identifier.pmid14755779-
dc.identifier.scopuseid_2-s2.0-3042733265en_US
dc.identifier.hkuros104565-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-3042733265&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume10en_US
dc.identifier.issue1en_US
dc.identifier.spage58en_US
dc.identifier.epage64en_US
dc.identifier.isiWOS:000220373600009-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridGirlanda, R=7003660543en_US
dc.identifier.scopusauthoridMohsen, AH=7006843678en_US
dc.identifier.scopusauthoridSmith, H=7406227469en_US
dc.identifier.scopusauthoridSablon, E=6603694538en_US
dc.identifier.scopusauthoridYuen, MF=7102031955en_US
dc.identifier.scopusauthoridO'Grady, J=7101652420en_US
dc.identifier.scopusauthoridMuiesan, P=7004114392en_US
dc.identifier.scopusauthoridRela, M=7005785802en_US
dc.identifier.scopusauthoridHeaton, N=7102942546en_US
dc.identifier.scopusauthoridNorris, S=7103213449en_US

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats