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Article: Symptoms, lung function, and β 2-adrenoceptor polymorphisms in a birth cohort followed for 10 years

TitleSymptoms, lung function, and β 2-adrenoceptor polymorphisms in a birth cohort followed for 10 years
Authors
Issue Date2004
PublisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jhome/39249
Citation
Pediatric Pulmonology, 2004, v. 38 n. 1, p. 75-81 How to Cite?
AbstractAs little is known about the natural history of bronchial responsiveness and the development of wheezing symptoms in early childhood, a cohort of children at risk of allergy, whose lung function and bronchial responsiveness had been measured in the neonatal period, was followed prospectively for 10 (SD, 0.8) years in order to determine the role of neonatal measurements on wheezing history and later lung function. A potential role for beta-2 adrenoceptor (β 2AR) polymorphisms in these relationships was also sought as a secondary objective. Of the original 73 children, wheezing history was available in 65 (89%), and 49 (67%) attended the laboratory for physiological measurements and genotyping of β 2AR. Wheezing was categorized as occurring 1) only before the fourth birthday, 2) after the fourth birthday, or 3) never. No relation was seen between neonatal and later lung function. However, neonatal bronchial responsiveness predicted subsequent FEV 1 (P=0.03). Increased neonatal bronchial responsiveness was associated with transient wheeze <4 years but not with later wheeze. Neonatal V′maxFRC was reduced in those possessing Gln 27 or Arg 16 alleles, but there was no effect of β 2AR polymorphisms on FEV 1 at 10 years. Wheeze after 4 years of age was typical of classical asthma, as it was strongly related to atopy and bronchial responsiveness at age 10. In conclusion, we confirmed the association of neonatal bronchial responsiveness with both early wheezing and later lung function. We also showed an influence of polymorphisms at both aa16 and aa27 on neonatal lung function. Wheezing beyond 4 years, typical of classical asthma, was unrelated to early measurements of lung function or bronchial responsiveness. © 2004 Wiley-Liss, Inc.
Persistent Identifierhttp://hdl.handle.net/10722/162928
ISSN
2015 Impact Factor: 2.85
2015 SCImago Journal Rankings: 0.910
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorWilson, NMen_US
dc.contributor.authorLamprill, JRen_US
dc.contributor.authorMak, JCWen_US
dc.contributor.authorClarke, JRen_US
dc.contributor.authorBush, Aen_US
dc.contributor.authorSilverman, Men_US
dc.date.accessioned2012-09-05T05:25:28Z-
dc.date.available2012-09-05T05:25:28Z-
dc.date.issued2004en_US
dc.identifier.citationPediatric Pulmonology, 2004, v. 38 n. 1, p. 75-81en_US
dc.identifier.issn8755-6863en_US
dc.identifier.urihttp://hdl.handle.net/10722/162928-
dc.description.abstractAs little is known about the natural history of bronchial responsiveness and the development of wheezing symptoms in early childhood, a cohort of children at risk of allergy, whose lung function and bronchial responsiveness had been measured in the neonatal period, was followed prospectively for 10 (SD, 0.8) years in order to determine the role of neonatal measurements on wheezing history and later lung function. A potential role for beta-2 adrenoceptor (β 2AR) polymorphisms in these relationships was also sought as a secondary objective. Of the original 73 children, wheezing history was available in 65 (89%), and 49 (67%) attended the laboratory for physiological measurements and genotyping of β 2AR. Wheezing was categorized as occurring 1) only before the fourth birthday, 2) after the fourth birthday, or 3) never. No relation was seen between neonatal and later lung function. However, neonatal bronchial responsiveness predicted subsequent FEV 1 (P=0.03). Increased neonatal bronchial responsiveness was associated with transient wheeze <4 years but not with later wheeze. Neonatal V′maxFRC was reduced in those possessing Gln 27 or Arg 16 alleles, but there was no effect of β 2AR polymorphisms on FEV 1 at 10 years. Wheeze after 4 years of age was typical of classical asthma, as it was strongly related to atopy and bronchial responsiveness at age 10. In conclusion, we confirmed the association of neonatal bronchial responsiveness with both early wheezing and later lung function. We also showed an influence of polymorphisms at both aa16 and aa27 on neonatal lung function. Wheezing beyond 4 years, typical of classical asthma, was unrelated to early measurements of lung function or bronchial responsiveness. © 2004 Wiley-Liss, Inc.en_US
dc.languageengen_US
dc.publisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jhome/39249en_US
dc.relation.ispartofPediatric Pulmonologyen_US
dc.subject.meshAnalysis Of Varianceen_US
dc.subject.meshAsthma - Epidemiology - Genetics - Physiopathologyen_US
dc.subject.meshBronchial Provocation Testsen_US
dc.subject.meshChilden_US
dc.subject.meshChild Development - Physiologyen_US
dc.subject.meshChild, Preschoolen_US
dc.subject.meshCohort Studiesen_US
dc.subject.meshConfidence Intervalsen_US
dc.subject.meshFemaleen_US
dc.subject.meshFollow-Up Studiesen_US
dc.subject.meshHumansen_US
dc.subject.meshInfanten_US
dc.subject.meshInfant, Newbornen_US
dc.subject.meshMaleen_US
dc.subject.meshOdds Ratioen_US
dc.subject.meshPolymorphism, Geneticen_US
dc.subject.meshPredictive Value Of Testsen_US
dc.subject.meshProspective Studiesen_US
dc.subject.meshReceptors, Adrenergic, Beta - Geneticsen_US
dc.subject.meshReference Valuesen_US
dc.subject.meshRespiratory Function Testsen_US
dc.subject.meshRespiratory Hypersensitivity - Diagnosisen_US
dc.subject.meshRespiratory Mechanicsen_US
dc.subject.meshRespiratory Physiological Phenomenaen_US
dc.subject.meshRespiratory Soundsen_US
dc.subject.meshTime Factorsen_US
dc.titleSymptoms, lung function, and β 2-adrenoceptor polymorphisms in a birth cohort followed for 10 yearsen_US
dc.typeArticleen_US
dc.identifier.emailMak, JCW:judymak@hku.hken_US
dc.identifier.authorityMak, JCW=rp00352en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1002/ppul.20049en_US
dc.identifier.pmid15170877-
dc.identifier.scopuseid_2-s2.0-3042686003en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-3042686003&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume38en_US
dc.identifier.issue1en_US
dc.identifier.spage75en_US
dc.identifier.epage81en_US
dc.identifier.isiWOS:000222395100010-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridWilson, NM=26023934300en_US
dc.identifier.scopusauthoridLamprill, JR=6508156578en_US
dc.identifier.scopusauthoridMak, JCW=7103323094en_US
dc.identifier.scopusauthoridClarke, JR=7403197680en_US
dc.identifier.scopusauthoridBush, A=7201882795en_US
dc.identifier.scopusauthoridSilverman, M=7403299289en_US

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