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Article: Risk factors associated with the development of intestinal metaplasia in first-degree relatives of gastric cancer patients

TitleRisk factors associated with the development of intestinal metaplasia in first-degree relatives of gastric cancer patients
Authors
Issue Date2005
Citation
Cancer Epidemiology Biomarkers And Prevention, 2005, v. 14 n. 12, p. 2982-2986 How to Cite?
AbstractFamily relatives of gastric cancer patients have a higher risk of gastric cancer and premalignant gastric lesions. We sought to determine the risk factors associated with the presence of intestinal metaplasia in a large cohort of gastric cancer relatives. First-degree relatives of gastric cancer patients were invited for screening gastroscopy. Endoscopic gastric biopsies were obtained from the antrum and corpus. Gastric biopsies were analyzed for Helicobacter pylori infection, severity of inflammation, and presence of intestinal metaplasia. Stepwise logistic regressions were used to identify for risk factors associated with presence of intestinal metaplasia in cancer relatives. Two hundred seventy cancer relatives underwent screening endoscopy (median age, 42; 47% male and 48% siblings). Among them, 161 (59.6%) were H. pylori positive and 81 (30%) had confirmed intestinal metaplasia. The following factors were found to be associated with the presence of intestinal metaplasia: age, male sex, H. pylori infection, birth order, alcohol use, siblings with stomach cancer, childhood living conditions, and water supply. Individuals with intestinal metaplasia had more severe acute and chronic inflammation in the antrum and corpus (P < 0.003). With multiple logistic regression, H. pylori infection [odds ratio (OR), 3.23], male gender (OR, 2.09), age (OR, 1.07), and a history of gastric cancer in siblings (OR, 1.91) were independent factors associated with the development of intestinal metaplasia in cancer relatives. In conclusion, we have identified risk factors associated with gastric intestinal metaplasia in stomach cancer relatives, which may be useful in the understanding of gastric carcinogenesis in these high-risk individuals. Copyright © 2005 American Association for Cancer Research.
Persistent Identifierhttp://hdl.handle.net/10722/162922
ISSN
2015 Impact Factor: 3.622
2015 SCImago Journal Rankings: 2.579
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorLeung, WKen_US
dc.contributor.authorNg, EKWen_US
dc.contributor.authorChan, WYen_US
dc.contributor.authorAuyeung, ACMen_US
dc.contributor.authorChan, KFen_US
dc.contributor.authorLam, CCHen_US
dc.contributor.authorChan, FKLen_US
dc.contributor.authorLau, JYWen_US
dc.contributor.authorSung, JJYen_US
dc.date.accessioned2012-09-05T05:25:21Z-
dc.date.available2012-09-05T05:25:21Z-
dc.date.issued2005en_US
dc.identifier.citationCancer Epidemiology Biomarkers And Prevention, 2005, v. 14 n. 12, p. 2982-2986en_US
dc.identifier.issn1055-9965en_US
dc.identifier.urihttp://hdl.handle.net/10722/162922-
dc.description.abstractFamily relatives of gastric cancer patients have a higher risk of gastric cancer and premalignant gastric lesions. We sought to determine the risk factors associated with the presence of intestinal metaplasia in a large cohort of gastric cancer relatives. First-degree relatives of gastric cancer patients were invited for screening gastroscopy. Endoscopic gastric biopsies were obtained from the antrum and corpus. Gastric biopsies were analyzed for Helicobacter pylori infection, severity of inflammation, and presence of intestinal metaplasia. Stepwise logistic regressions were used to identify for risk factors associated with presence of intestinal metaplasia in cancer relatives. Two hundred seventy cancer relatives underwent screening endoscopy (median age, 42; 47% male and 48% siblings). Among them, 161 (59.6%) were H. pylori positive and 81 (30%) had confirmed intestinal metaplasia. The following factors were found to be associated with the presence of intestinal metaplasia: age, male sex, H. pylori infection, birth order, alcohol use, siblings with stomach cancer, childhood living conditions, and water supply. Individuals with intestinal metaplasia had more severe acute and chronic inflammation in the antrum and corpus (P < 0.003). With multiple logistic regression, H. pylori infection [odds ratio (OR), 3.23], male gender (OR, 2.09), age (OR, 1.07), and a history of gastric cancer in siblings (OR, 1.91) were independent factors associated with the development of intestinal metaplasia in cancer relatives. In conclusion, we have identified risk factors associated with gastric intestinal metaplasia in stomach cancer relatives, which may be useful in the understanding of gastric carcinogenesis in these high-risk individuals. Copyright © 2005 American Association for Cancer Research.en_US
dc.languageengen_US
dc.relation.ispartofCancer Epidemiology Biomarkers and Preventionen_US
dc.subject.meshAdenocarcinoma - Geneticsen_US
dc.subject.meshAdulten_US
dc.subject.meshChi-Square Distributionen_US
dc.subject.meshEndoscopy, Gastrointestinalen_US
dc.subject.meshFemaleen_US
dc.subject.meshHelicobacter Infections - Epidemiologyen_US
dc.subject.meshHelicobacter Pylorien_US
dc.subject.meshHumansen_US
dc.subject.meshIntestines - Pathologyen_US
dc.subject.meshLogistic Modelsen_US
dc.subject.meshMaleen_US
dc.subject.meshMetaplasia - Geneticsen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshRisk Factorsen_US
dc.subject.meshStatistics, Nonparametricen_US
dc.subject.meshStomach Neoplasms - Geneticsen_US
dc.titleRisk factors associated with the development of intestinal metaplasia in first-degree relatives of gastric cancer patientsen_US
dc.typeArticleen_US
dc.identifier.emailLeung, WK:waikleung@hku.hken_US
dc.identifier.authorityLeung, WK=rp01479en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1158/1055-9965.EPI-05-0181en_US
dc.identifier.pmid16365021-
dc.identifier.scopuseid_2-s2.0-30344471104en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-30344471104&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume14en_US
dc.identifier.issue12en_US
dc.identifier.spage2982en_US
dc.identifier.epage2986en_US
dc.identifier.isiWOS:000234055600027-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridLeung, WK=7201504523en_US
dc.identifier.scopusauthoridNg, EKW=7201647539en_US
dc.identifier.scopusauthoridChan, WY=37041920900en_US
dc.identifier.scopusauthoridAuyeung, ACM=12760347200en_US
dc.identifier.scopusauthoridChan, KF=14324453900en_US
dc.identifier.scopusauthoridLam, CCH=14321941100en_US
dc.identifier.scopusauthoridChan, FKL=7202586434en_US
dc.identifier.scopusauthoridLau, JYW=13907867100en_US
dc.identifier.scopusauthoridSung, JJY=24473715000en_US

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