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Article: Analysis of TGF-β1 gene polymorphisms in Hong Kong Chinese patients with asthma

TitleAnalysis of TGF-β1 gene polymorphisms in Hong Kong Chinese patients with asthma
Authors
Issue Date2006
PublisherMosby, Inc. The Journal's web site is located at http://www.elsevier.com/locate/jaci
Citation
Journal Of Allergy And Clinical Immunology, 2006, v. 117 n. 1, p. 92-96 How to Cite?
AbstractBackground: The C-509T polymorphism of TGF-β1 gene has been associated with asthma and atopy in white populations. Objective: We investigated the association between asthma and previously identified polymorphisms at C-509T and T869C of the TGF-β1 gene among 250 Chinese patients with asthma and 308 healthy controls in Hong Kong. Methods: Genotyping was performed on peripheral blood genomic DNA by using PCR-RFLP. Results: There were no differences in the frequencies of genotypes and alleles between patients and controls. The C-509T and T869C polymorphisms were in tight linkage disequilibrium (P < .01). Among atopic subjects, significant differences were found in genotype and allele frequencies for T869C polymorphism between patients and controls (P = .014 and P = .019, respectively), and individuals bearing the CC genotype were associated with increased risk for the development of asthma (odds ratio, 2.58; 95% CI, 1.17-5.66; P = .018) after adjusting for age, sex, and smoking status. Individuals with asthma bearing the CT genotype of the C-509T polymorphism had significantly increased risk for severe airflow obstruction compared with individuals who had mild obstruction (odds ratio, 4.00; 95% CI, 1.06-15.08; P = .035). Conclusion: Our results indicate that the polymorphisms at C-509T and T869C of the TGF- β1 gene are associated with asthma susceptibility in atopic subjects of the Hong Kong Chinese population, and the C-509T polymorphism may play a role in the pathogenesis of airflow obstruction. © 2005 American Academy of Allergy, Asthma and Immunology.
Persistent Identifierhttp://hdl.handle.net/10722/162920
ISSN
2015 Impact Factor: 12.485
2015 SCImago Journal Rankings: 5.513
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorMak, JCWen_US
dc.contributor.authorLeung, HCMen_US
dc.contributor.authorHo, SPen_US
dc.contributor.authorLaw, BKWen_US
dc.contributor.authorHo, ASSen_US
dc.contributor.authorLam, WKen_US
dc.contributor.authorIp, MSMen_US
dc.contributor.authorChanYeung, MMWen_US
dc.date.accessioned2012-09-05T05:25:16Z-
dc.date.available2012-09-05T05:25:16Z-
dc.date.issued2006en_US
dc.identifier.citationJournal Of Allergy And Clinical Immunology, 2006, v. 117 n. 1, p. 92-96en_US
dc.identifier.issn0091-6749en_US
dc.identifier.urihttp://hdl.handle.net/10722/162920-
dc.description.abstractBackground: The C-509T polymorphism of TGF-β1 gene has been associated with asthma and atopy in white populations. Objective: We investigated the association between asthma and previously identified polymorphisms at C-509T and T869C of the TGF-β1 gene among 250 Chinese patients with asthma and 308 healthy controls in Hong Kong. Methods: Genotyping was performed on peripheral blood genomic DNA by using PCR-RFLP. Results: There were no differences in the frequencies of genotypes and alleles between patients and controls. The C-509T and T869C polymorphisms were in tight linkage disequilibrium (P < .01). Among atopic subjects, significant differences were found in genotype and allele frequencies for T869C polymorphism between patients and controls (P = .014 and P = .019, respectively), and individuals bearing the CC genotype were associated with increased risk for the development of asthma (odds ratio, 2.58; 95% CI, 1.17-5.66; P = .018) after adjusting for age, sex, and smoking status. Individuals with asthma bearing the CT genotype of the C-509T polymorphism had significantly increased risk for severe airflow obstruction compared with individuals who had mild obstruction (odds ratio, 4.00; 95% CI, 1.06-15.08; P = .035). Conclusion: Our results indicate that the polymorphisms at C-509T and T869C of the TGF- β1 gene are associated with asthma susceptibility in atopic subjects of the Hong Kong Chinese population, and the C-509T polymorphism may play a role in the pathogenesis of airflow obstruction. © 2005 American Academy of Allergy, Asthma and Immunology.en_US
dc.languageengen_US
dc.publisherMosby, Inc. The Journal's web site is located at http://www.elsevier.com/locate/jacien_US
dc.relation.ispartofJournal of Allergy and Clinical Immunologyen_US
dc.rightsJournal of Allergy and Clinical Immunology. Copyright © Mosby, Inc.-
dc.subject.meshAdulten_US
dc.subject.meshAgeden_US
dc.subject.meshAsthma - Geneticsen_US
dc.subject.meshFemaleen_US
dc.subject.meshGene Frequencyen_US
dc.subject.meshGenetic Predisposition To Diseaseen_US
dc.subject.meshHumansen_US
dc.subject.meshLogistic Modelsen_US
dc.subject.meshMaleen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshPolymorphism, Geneticen_US
dc.subject.meshTransforming Growth Factor Beta - Geneticsen_US
dc.subject.meshTransforming Growth Factor Beta1en_US
dc.titleAnalysis of TGF-β1 gene polymorphisms in Hong Kong Chinese patients with asthmaen_US
dc.typeArticleen_US
dc.identifier.emailMak, JCW:judymak@hku.hken_US
dc.identifier.emailIp, MSM:msmip@hku.hken_US
dc.identifier.authorityMak, JCW=rp00352en_US
dc.identifier.authorityIp, MSM=rp00347en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1016/j.jaci.2005.08.049en_US
dc.identifier.pmid16387590en_US
dc.identifier.scopuseid_2-s2.0-29544443161en_US
dc.identifier.hkuros119040-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-29544443161&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume117en_US
dc.identifier.issue1en_US
dc.identifier.spage92en_US
dc.identifier.epage96en_US
dc.identifier.isiWOS:000235687100015-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridMak, JCW=7103323094en_US
dc.identifier.scopusauthoridLeung, HCM=34968372500en_US
dc.identifier.scopusauthoridHo, SP=12794365900en_US
dc.identifier.scopusauthoridLaw, BKW=36639650600en_US
dc.identifier.scopusauthoridHo, ASS=7402675199en_US
dc.identifier.scopusauthoridLam, WK=7203021937en_US
dc.identifier.scopusauthoridIp, MSM=7102423259en_US
dc.identifier.scopusauthoridChanYeung, MMW=54790582200en_US

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