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Article: p53-independent pRB degradation contributes to a drug-induced apoptosis in AGS cells

Titlep53-independent pRB degradation contributes to a drug-induced apoptosis in AGS cells
Authors
Issue Date2005
PublisherNature Publishing Group. The Journal's web site is located at http://www.nature.com/cr/marketing/index.html
Citation
Cell Research, 2005, v. 15 n. 9, p. 695-703 How to Cite?
AbstractThe retinoblastoma (RB) tumor suppressor protein, pRB, plays an important role in the regulation of mammalian cell cycle. Furthermore, several lines of evidence suggest that pRB also involves in the regulation of apoptosis. In the present study, the degradation of pRB was observed in apoptotic gastric tumor cells treated with a new potent anti-tumor component, tripchlorolide (TC). The inhibition of pRB degradation by a general cysteine protease inhibitor IDAM resulted in the reduction of the apoptotic cells. Furthermore, the survival of the gastric tumor cells under the TC treatment was enhanced by an over-expression of exogenous pRB. These results suggest that the pRB degradation of the gastric tumor cells under the TC treatment involves in the apoptotic progression. In addition, the same extent of TC-induced pRB-degradation was detected in the gastric tumor cells containing a p53 dominant-negative construct, indicating that this kind of pRB degradation is p53-independent.
Persistent Identifierhttp://hdl.handle.net/10722/162906
ISSN
2015 Impact Factor: 14.812
2015 SCImago Journal Rankings: 4.805
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorJin, Yen_US
dc.contributor.authorLeung, WKen_US
dc.contributor.authorSung, JJYen_US
dc.contributor.authorWu, JRen_US
dc.date.accessioned2012-09-05T05:25:08Z-
dc.date.available2012-09-05T05:25:08Z-
dc.date.issued2005en_US
dc.identifier.citationCell Research, 2005, v. 15 n. 9, p. 695-703en_US
dc.identifier.issn1001-0602en_US
dc.identifier.urihttp://hdl.handle.net/10722/162906-
dc.description.abstractThe retinoblastoma (RB) tumor suppressor protein, pRB, plays an important role in the regulation of mammalian cell cycle. Furthermore, several lines of evidence suggest that pRB also involves in the regulation of apoptosis. In the present study, the degradation of pRB was observed in apoptotic gastric tumor cells treated with a new potent anti-tumor component, tripchlorolide (TC). The inhibition of pRB degradation by a general cysteine protease inhibitor IDAM resulted in the reduction of the apoptotic cells. Furthermore, the survival of the gastric tumor cells under the TC treatment was enhanced by an over-expression of exogenous pRB. These results suggest that the pRB degradation of the gastric tumor cells under the TC treatment involves in the apoptotic progression. In addition, the same extent of TC-induced pRB-degradation was detected in the gastric tumor cells containing a p53 dominant-negative construct, indicating that this kind of pRB degradation is p53-independent.en_US
dc.languageengen_US
dc.publisherNature Publishing Group. The Journal's web site is located at http://www.nature.com/cr/marketing/index.htmlen_US
dc.relation.ispartofCell Researchen_US
dc.subject.meshApoptosisen_US
dc.subject.meshBlotting, Westernen_US
dc.subject.meshCell Cycleen_US
dc.subject.meshCell Line, Tumoren_US
dc.subject.meshComet Assayen_US
dc.subject.meshCysteine Endopeptidases - Metabolismen_US
dc.subject.meshCysteine Proteinase Inhibitors - Pharmacologyen_US
dc.subject.meshCytosol - Metabolismen_US
dc.subject.meshDna Damageen_US
dc.subject.meshDna Fragmentationen_US
dc.subject.meshDiterpenes - Pharmacologyen_US
dc.subject.meshElectrophoresis, Polyacrylamide Gelen_US
dc.subject.meshEnzyme Inhibitors - Pharmacologyen_US
dc.subject.meshFlow Cytometryen_US
dc.subject.meshGene Expression Regulationen_US
dc.subject.meshGene Expression Regulation, Neoplasticen_US
dc.subject.meshGenes, Dominanten_US
dc.subject.meshHumansen_US
dc.subject.meshMitochondria - Metabolismen_US
dc.subject.meshPhenanthrenes - Pharmacologyen_US
dc.subject.meshPlasmids - Metabolismen_US
dc.subject.meshProteasome Endopeptidase Complex - Metabolismen_US
dc.subject.meshRetinoblastoma Protein - Metabolism - Physiologyen_US
dc.subject.meshStomach Neoplasms - Drug Therapy - Pathologyen_US
dc.subject.meshTumor Suppressor Protein P53 - Metabolism - Physiologyen_US
dc.titlep53-independent pRB degradation contributes to a drug-induced apoptosis in AGS cellsen_US
dc.typeArticleen_US
dc.identifier.emailLeung, WK:waikleung@hku.hken_US
dc.identifier.authorityLeung, WK=rp01479en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1038/sj.cr.7290339en_US
dc.identifier.pmid16212876-
dc.identifier.scopuseid_2-s2.0-27944443701en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-27944443701&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume15en_US
dc.identifier.issue9en_US
dc.identifier.spage695en_US
dc.identifier.epage703en_US
dc.identifier.isiWOS:000232349100003-
dc.publisher.placeUnited Kingdomen_US
dc.identifier.scopusauthoridJin, Y=55215772900en_US
dc.identifier.scopusauthoridLeung, WK=7201504523en_US
dc.identifier.scopusauthoridSung, JJY=35405352400en_US
dc.identifier.scopusauthoridWu, JR=7409253402en_US

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