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Article: Promoter hypermethylation of Death-associated protein-kinase gene associated with advance stage gastric cancer.

TitlePromoter hypermethylation of Death-associated protein-kinase gene associated with advance stage gastric cancer.
Authors
Issue Date2005
PublisherDemetrios A Spandidos Ed & Pub. The Journal's web site is located at http://147.52.72.117/OR/or.htm
Citation
Oncology Reports, 2005, v. 13 n. 5, p. 937-941 How to Cite?
AbstractDeath-associated protein kinase (DAP-kinase) is a serine/threonine kinase and a positive mediator of apoptosis. Down-regulation of DAP-kinase was associated with increased metastatic potential of tumors. Gene promoter hypermethylation could lead to down-regulation of DAP-kinase. We aimed to investigate the frequency of gene promoter methylation of DAP-kinase in gastric carcinoma (GCA) and assessed its association with clinicopathological features. One hundred and seven cases of gastric carcinoma were examined. The relevant clinical and pathological features, including survival data were reviewed. Methylation status was assessed by methylation-specific PCR (MSP). Seventy-four cases (69.2%) of GCA demonstrated promoter methylation of DAP-kinase. Methylation of DAP-kinase was observed in intestinal, diffuse and mixed type of GCA. It also occurred in similar frequency among antral, body and cardiac gastric cancer. No association between methylation status and age or gender was demonstrated. However, the methylated cases correlated with the presence of nodal metastasis (p=0.041), advance stage of disease (p=0.029) and a poorer event-free survival (log-rank test p=0.0141). DAP-kinase promoter methylation as a potential prognostic marker for gastric cancer patients deserved further evaluation.
Persistent Identifierhttp://hdl.handle.net/10722/162882
ISSN
2015 Impact Factor: 2.486
2015 SCImago Journal Rankings: 0.968
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorChan, AWen_US
dc.contributor.authorChan, MWen_US
dc.contributor.authorLee, TLen_US
dc.contributor.authorNg, EKen_US
dc.contributor.authorLeung, WKen_US
dc.contributor.authorLau, JYen_US
dc.contributor.authorTong, JHen_US
dc.contributor.authorChan, FKen_US
dc.contributor.authorTo, KFen_US
dc.date.accessioned2012-09-05T05:24:43Z-
dc.date.available2012-09-05T05:24:43Z-
dc.date.issued2005en_US
dc.identifier.citationOncology Reports, 2005, v. 13 n. 5, p. 937-941en_US
dc.identifier.issn1021-335Xen_US
dc.identifier.urihttp://hdl.handle.net/10722/162882-
dc.description.abstractDeath-associated protein kinase (DAP-kinase) is a serine/threonine kinase and a positive mediator of apoptosis. Down-regulation of DAP-kinase was associated with increased metastatic potential of tumors. Gene promoter hypermethylation could lead to down-regulation of DAP-kinase. We aimed to investigate the frequency of gene promoter methylation of DAP-kinase in gastric carcinoma (GCA) and assessed its association with clinicopathological features. One hundred and seven cases of gastric carcinoma were examined. The relevant clinical and pathological features, including survival data were reviewed. Methylation status was assessed by methylation-specific PCR (MSP). Seventy-four cases (69.2%) of GCA demonstrated promoter methylation of DAP-kinase. Methylation of DAP-kinase was observed in intestinal, diffuse and mixed type of GCA. It also occurred in similar frequency among antral, body and cardiac gastric cancer. No association between methylation status and age or gender was demonstrated. However, the methylated cases correlated with the presence of nodal metastasis (p=0.041), advance stage of disease (p=0.029) and a poorer event-free survival (log-rank test p=0.0141). DAP-kinase promoter methylation as a potential prognostic marker for gastric cancer patients deserved further evaluation.en_US
dc.languageengen_US
dc.publisherDemetrios A Spandidos Ed & Pub. The Journal's web site is located at http://147.52.72.117/OR/or.htmen_US
dc.relation.ispartofOncology reportsen_US
dc.subject.meshApoptosis Regulatory Proteinsen_US
dc.subject.meshCalcium-Calmodulin-Dependent Protein Kinases - Geneticsen_US
dc.subject.meshDna Methylationen_US
dc.subject.meshDna Primersen_US
dc.subject.meshDna, Neoplasm - Genetics - Isolation & Purificationen_US
dc.subject.meshDisease-Free Survivalen_US
dc.subject.meshFemaleen_US
dc.subject.meshGenetic Markersen_US
dc.subject.meshHumansen_US
dc.subject.meshMaleen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshNeoplasm Stagingen_US
dc.subject.meshPolymerase Chain Reactionen_US
dc.subject.meshPromoter Regions, Geneticen_US
dc.subject.meshStomach Neoplasms - Enzymology - Genetics - Pathologyen_US
dc.titlePromoter hypermethylation of Death-associated protein-kinase gene associated with advance stage gastric cancer.en_US
dc.typeArticleen_US
dc.identifier.emailLeung, WK:waikleung@hku.hken_US
dc.identifier.authorityLeung, WK=rp01479en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.pmid15809761-
dc.identifier.scopuseid_2-s2.0-25144476600en_US
dc.identifier.volume13en_US
dc.identifier.issue5en_US
dc.identifier.spage937en_US
dc.identifier.epage941en_US
dc.identifier.isiWOS:000228440500023-
dc.publisher.placeGreeceen_US
dc.identifier.scopusauthoridChan, AW=37019607700en_US
dc.identifier.scopusauthoridChan, MW=7402597788en_US
dc.identifier.scopusauthoridLee, TL=35292432600en_US
dc.identifier.scopusauthoridNg, EK=7201647539en_US
dc.identifier.scopusauthoridLeung, WK=7201504523en_US
dc.identifier.scopusauthoridLau, JY=13907867100en_US
dc.identifier.scopusauthoridTong, JH=7202724564en_US
dc.identifier.scopusauthoridChan, FK=7202586434en_US
dc.identifier.scopusauthoridTo, KF=7101911940en_US

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