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Article: Polymorphisms of the GSTM1, GSTP1, MPO, XRCC1, and NQO1 genes in Chinese patients with non-small cell lung cancers: Relationship with aberrant promoter methylation of the CDKN2A and RARB genes

TitlePolymorphisms of the GSTM1, GSTP1, MPO, XRCC1, and NQO1 genes in Chinese patients with non-small cell lung cancers: Relationship with aberrant promoter methylation of the CDKN2A and RARB genes
Authors
Issue Date2005
PublisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/cancergene
Citation
Cancer Genetics And Cytogenetics, 2005, v. 162 n. 1, p. 10-20 How to Cite?
AbstractAn association between functional polymorphisms of genes resulting in decreased detoxification of carcinogens or DNA repair and aberrant promoter methylation is an attractive hypothesis in lung carcinogenesis. The genotypes at polymorphic sites of the glutathione S-transferase (GST) M1 (null/wildtype) and P1 (nucleotide 2627 A/G), myeloperoxidase (MPO) (nucleotide -463 G/A), X-ray repair cross-complementing group 1 (XRCC1) (nucleotides 26304 C/T; 28152 G/A), and NADPH quinine oxidoreductase (NQO1) (nucleotide 609 C/T) genes in 75 Chinese patients with non-small cell lung cancer (NSCLC) were characterized with polymerase chain reaction-restriction fragment length polymorphism. Results were correlated with aberrant methylation of the CDKN2A (alias p16INK4A), retinoic acid receptor beta (RARB), methylguanine-DNA methyltransferase (MGMT), and death-associated-protein (DAP) kinase genes in the tumors. In comparison with an age-matched control, none of the polymorphisms were associated with increased lung cancer risks. In male patients, however, the MPO -463 GG homozygous state was associated with CDKN2A (alias p16INK4A) methylation (odds ratio OR = 3.63, 95% confidence interval CI = 1.26-10.51), and the XRCC1 26304 T allele in the heterozygous/homozygous state was associated with methylation of CDKN2A (OR = 6.13, 95% CI = 1.55-24.16) and RARB (OR = 7.67, 95% CI = 1.62-36.18). In female patients, the GSTP1 G allele in the heterozygous/homozygous state was associated with RARB methylation (OR = 18.0, 95% CI = 0.76-427.29). These results showed that functional deficiencies in metabolic pathways that protect cells from carcinogen induced DNA damage might be linked to aberrant promoter methylation of the CDKN2A and RARB genes during lung carcinogenesis. © 2005 Elsevier Inc. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/162880
ISSN
2012 Impact Factor: 1.929
2013 SCImago Journal Rankings: 0.872
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorChan, ECen_US
dc.contributor.authorLam, SYen_US
dc.contributor.authorFu, KHen_US
dc.contributor.authorKwong, YLen_US
dc.date.accessioned2012-09-05T05:24:41Z-
dc.date.available2012-09-05T05:24:41Z-
dc.date.issued2005en_US
dc.identifier.citationCancer Genetics And Cytogenetics, 2005, v. 162 n. 1, p. 10-20en_US
dc.identifier.issn0165-4608en_US
dc.identifier.urihttp://hdl.handle.net/10722/162880-
dc.description.abstractAn association between functional polymorphisms of genes resulting in decreased detoxification of carcinogens or DNA repair and aberrant promoter methylation is an attractive hypothesis in lung carcinogenesis. The genotypes at polymorphic sites of the glutathione S-transferase (GST) M1 (null/wildtype) and P1 (nucleotide 2627 A/G), myeloperoxidase (MPO) (nucleotide -463 G/A), X-ray repair cross-complementing group 1 (XRCC1) (nucleotides 26304 C/T; 28152 G/A), and NADPH quinine oxidoreductase (NQO1) (nucleotide 609 C/T) genes in 75 Chinese patients with non-small cell lung cancer (NSCLC) were characterized with polymerase chain reaction-restriction fragment length polymorphism. Results were correlated with aberrant methylation of the CDKN2A (alias p16INK4A), retinoic acid receptor beta (RARB), methylguanine-DNA methyltransferase (MGMT), and death-associated-protein (DAP) kinase genes in the tumors. In comparison with an age-matched control, none of the polymorphisms were associated with increased lung cancer risks. In male patients, however, the MPO -463 GG homozygous state was associated with CDKN2A (alias p16INK4A) methylation (odds ratio OR = 3.63, 95% confidence interval CI = 1.26-10.51), and the XRCC1 26304 T allele in the heterozygous/homozygous state was associated with methylation of CDKN2A (OR = 6.13, 95% CI = 1.55-24.16) and RARB (OR = 7.67, 95% CI = 1.62-36.18). In female patients, the GSTP1 G allele in the heterozygous/homozygous state was associated with RARB methylation (OR = 18.0, 95% CI = 0.76-427.29). These results showed that functional deficiencies in metabolic pathways that protect cells from carcinogen induced DNA damage might be linked to aberrant promoter methylation of the CDKN2A and RARB genes during lung carcinogenesis. © 2005 Elsevier Inc. All rights reserved.en_US
dc.languageengen_US
dc.publisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/cancergeneen_US
dc.relation.ispartofCancer Genetics and Cytogeneticsen_US
dc.subject.meshAsian Continental Ancestry Groupen_US
dc.subject.meshCarcinoma, Non-Small-Cell Lung - Geneticsen_US
dc.subject.meshDna Methylationen_US
dc.subject.meshDna-Binding Proteins - Geneticsen_US
dc.subject.meshFemaleen_US
dc.subject.meshGenes, P16en_US
dc.subject.meshGenotypeen_US
dc.subject.meshGlutathione S-Transferase Pien_US
dc.subject.meshGlutathione Transferase - Geneticsen_US
dc.subject.meshGranulocyte Colony-Stimulating Factoren_US
dc.subject.meshHematopoietic Cell Growth Factors - Geneticsen_US
dc.subject.meshHumansen_US
dc.subject.meshInterleukin-3en_US
dc.subject.meshIsoenzymes - Geneticsen_US
dc.subject.meshLung Neoplasms - Geneticsen_US
dc.subject.meshMaleen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshPolymorphism, Geneticen_US
dc.subject.meshPromoter Regions, Geneticen_US
dc.subject.meshReceptors, Retinoic Acid - Geneticsen_US
dc.subject.meshRecombinant Fusion Proteins - Geneticsen_US
dc.subject.meshRecombinant Proteinsen_US
dc.titlePolymorphisms of the GSTM1, GSTP1, MPO, XRCC1, and NQO1 genes in Chinese patients with non-small cell lung cancers: Relationship with aberrant promoter methylation of the CDKN2A and RARB genesen_US
dc.typeArticleen_US
dc.identifier.emailKwong, YL:ylkwong@hku.hken_US
dc.identifier.authorityKwong, YL=rp00358en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1016/j.cancergencyto.2005.03.008en_US
dc.identifier.pmid16157195-
dc.identifier.scopuseid_2-s2.0-24644442180en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-24644442180&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume162en_US
dc.identifier.issue1en_US
dc.identifier.spage10en_US
dc.identifier.epage20en_US
dc.identifier.isiWOS:000232200200002-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridChan, EC=7401994120en_US
dc.identifier.scopusauthoridLam, SY=7402279461en_US
dc.identifier.scopusauthoridFu, KH=7202283800en_US
dc.identifier.scopusauthoridKwong, YL=7102818954en_US
dc.identifier.citeulike5269084-

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