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Article: Strain rate imaging differentiates transmural from non-transmural myocardial infarction: A validation study using delayed-enhancement magnetic resonance imaging

TitleStrain rate imaging differentiates transmural from non-transmural myocardial infarction: A validation study using delayed-enhancement magnetic resonance imaging
Authors
Issue Date2005
PublisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/jac
Citation
Journal Of The American College Of Cardiology, 2005, v. 46 n. 5, p. 864-871 How to Cite?
AbstractOBJECTIVES: The aim of this study was to determine if strain rate imaging (SRI) correlates with the transmural extent of myocardial infarction (MI) measured by contrast-enhanced magnetic resonance imaging (Ce-MRI). BACKGROUND: Identification of the transmural extent of myocardial necrosis and degree of non-viability after acute MI is clinically important. METHODS: Tissue Doppler echocardiography with SRI and Ce-MRI were performed in 47 consecutive patients with a first acute MI between days 2 and 6 and compared to 60 age-matched healthy volunteers. Peak myocardial velocities and peak myocardial deformation strain rates were measured. Location and size of the infarct zone was confirmed by Ce-MRI using the delayed enhancement technique with a 16-segment model. RESULTS: Contrast-enhanced MRI identified transmural infarction in 21 patients, non-transmural infarction in 15 (mean transmurality of infarct 72.3 ± 10.6%), and another 11 patients with subendocardial infarction (<50% transmural extent of the left ventricular wall). Peak systolic strain rate (SRs) of the transmural infarction segments was significantly lower compared to normal myocardium or with non-transmural infarction segments (both p < 0.0005). A cutoff value of SRs >-0.59 s -1 detected a transmural infarction with high sensitivity (90.9%) and high specificity (96.4%), and -0.98 s -1 >SRs >-1.26 s -1 distinguished subendocardial infarction from normal myocardium with a sensitivity of 81.3% and a specificity of 83.3%. CONCLUSIONS: Peak myocardial deformation by SRI can differentiate transmural from non-transmural MI, and it allows noninvasive determination of transmurality of the scar after MI and thereby the extent of non-viable myocardium. © 2005 by the American College of Cardiology Foundation.
Persistent Identifierhttp://hdl.handle.net/10722/162875
ISSN
2015 Impact Factor: 17.759
2015 SCImago Journal Rankings: 10.097
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorZhang, Yen_HK
dc.contributor.authorChan, AKYen_HK
dc.contributor.authorYu, CMen_HK
dc.contributor.authorYip, GWKen_HK
dc.contributor.authorFung, JWHen_HK
dc.contributor.authorLam, WWMen_HK
dc.contributor.authorSo, NMCen_HK
dc.contributor.authorWang, Men_HK
dc.contributor.authorWu, EBen_HK
dc.contributor.authorWong, JTen_HK
dc.contributor.authorSanderson, JEen_HK
dc.date.accessioned2012-09-05T05:24:39Z-
dc.date.available2012-09-05T05:24:39Z-
dc.date.issued2005en_HK
dc.identifier.citationJournal Of The American College Of Cardiology, 2005, v. 46 n. 5, p. 864-871en_HK
dc.identifier.issn0735-1097en_HK
dc.identifier.urihttp://hdl.handle.net/10722/162875-
dc.description.abstractOBJECTIVES: The aim of this study was to determine if strain rate imaging (SRI) correlates with the transmural extent of myocardial infarction (MI) measured by contrast-enhanced magnetic resonance imaging (Ce-MRI). BACKGROUND: Identification of the transmural extent of myocardial necrosis and degree of non-viability after acute MI is clinically important. METHODS: Tissue Doppler echocardiography with SRI and Ce-MRI were performed in 47 consecutive patients with a first acute MI between days 2 and 6 and compared to 60 age-matched healthy volunteers. Peak myocardial velocities and peak myocardial deformation strain rates were measured. Location and size of the infarct zone was confirmed by Ce-MRI using the delayed enhancement technique with a 16-segment model. RESULTS: Contrast-enhanced MRI identified transmural infarction in 21 patients, non-transmural infarction in 15 (mean transmurality of infarct 72.3 ± 10.6%), and another 11 patients with subendocardial infarction (<50% transmural extent of the left ventricular wall). Peak systolic strain rate (SRs) of the transmural infarction segments was significantly lower compared to normal myocardium or with non-transmural infarction segments (both p < 0.0005). A cutoff value of SRs >-0.59 s -1 detected a transmural infarction with high sensitivity (90.9%) and high specificity (96.4%), and -0.98 s -1 >SRs >-1.26 s -1 distinguished subendocardial infarction from normal myocardium with a sensitivity of 81.3% and a specificity of 83.3%. CONCLUSIONS: Peak myocardial deformation by SRI can differentiate transmural from non-transmural MI, and it allows noninvasive determination of transmurality of the scar after MI and thereby the extent of non-viable myocardium. © 2005 by the American College of Cardiology Foundation.en_HK
dc.languageengen_US
dc.publisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/jacen_HK
dc.relation.ispartofJournal of the American College of Cardiologyen_HK
dc.subject.meshAcute Diseaseen_US
dc.subject.meshAgeden_US
dc.subject.meshCase-Control Studiesen_US
dc.subject.meshContrast Mediaen_US
dc.subject.meshCoronary Stenosis - Diagnosisen_US
dc.subject.meshEchocardiography, Doppleren_US
dc.subject.meshFemaleen_US
dc.subject.meshGadolinium Dtpa - Diagnostic Useen_US
dc.subject.meshHong Kongen_US
dc.subject.meshHumansen_US
dc.subject.meshMagnetic Resonance Imaging, Cine - Methodsen_US
dc.subject.meshMaleen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshMyocardial Infarction - Diagnosis - Ultrasonographyen_US
dc.subject.meshTime Factorsen_US
dc.titleStrain rate imaging differentiates transmural from non-transmural myocardial infarction: A validation study using delayed-enhancement magnetic resonance imagingen_HK
dc.typeArticleen_HK
dc.identifier.emailWang, M: meiwang@hkucc.hku.hken_HK
dc.identifier.emailWong, JT: jwong@hkucc.hku.hken_HK
dc.identifier.authorityWang, M=rp00281en_HK
dc.identifier.authorityWong, JT=rp00322en_HK
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1016/j.jacc.2005.05.054en_HK
dc.identifier.pmid16139138-
dc.identifier.scopuseid_2-s2.0-24044550767en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-24044550767&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume46en_HK
dc.identifier.issue5en_HK
dc.identifier.spage864en_HK
dc.identifier.epage871en_HK
dc.identifier.isiWOS:000231635300020-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridZhang, Y=7601312580en_HK
dc.identifier.scopusauthoridChan, AKY=7403168116en_HK
dc.identifier.scopusauthoridYu, CM=7404976646en_HK
dc.identifier.scopusauthoridYip, GWK=7006525328en_HK
dc.identifier.scopusauthoridFung, JWH=7203073343en_HK
dc.identifier.scopusauthoridLam, WWM=13410486800en_HK
dc.identifier.scopusauthoridSo, NMC=7003780596en_HK
dc.identifier.scopusauthoridWang, M=7406690398en_HK
dc.identifier.scopusauthoridWu, EB=9234022900en_HK
dc.identifier.scopusauthoridWong, JT=8049324500en_HK
dc.identifier.scopusauthoridSanderson, JE=7202371250en_HK
dc.identifier.citeulike437197-

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