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Article: Antioxidant enzyme activities in healthy Chinese adults: Influence of age, gender and smoking

TitleAntioxidant enzyme activities in healthy Chinese adults: Influence of age, gender and smoking
Authors
Issue Date2005
PublisherBlackwell Publishing Asia. The Journal's web site is located at http://www.blackwellpublishing.com/journals/RES
Citation
Respirology, 2005, v. 10 n. 3, p. 305-309 How to Cite?
AbstractObjective: Specific antioxidant enzymes play a vital role in regulating and maintaining oxidant species. The aim of this study was to determine these antioxidant enzyme activities (i.e. catalase (CAT), superoxide dismutase (SOD) and glutathione peroxidase (GPx)) in erythrocytes from a group of healthy Chinese subjects and to study the influence of age, gender and smoking habits on the enzyme activities. Methodology: Chinese healthy subjects (n = 276) were grouped according to their age range, gender differences and smoking habits. Antioxidant enzyme activities were measured spectrophotometrically using standard kinetic methods. Results: There was a significant decrease in erythrocyte GPx activity in ever-smokers compared with non-smokers (47.10 ± 1.33 mU/g haemoglobin (Hb) vs. 51.41 ± 1.64 mU/g Hb, P < 0.05). Age-related significant increases in erythrocyte CAT and SOD activities were found in non-smokers but not in ever-smokers. There was no age-related difference in erythrocyte GPx activity in either non-smokers or ever-smokers. Among those >60 years old, erythrocyte CAT and GPx activities were significantly lower in ever-smokers than in non-smokers (29.70 ± 3.07 mU/g Hb vs. 41.63 ± 4.92 mU/g Hb (P < 0.05), and 47.55 ± 2.00 mU/g Hb vs. 55.30 ± 3.60 mU/g Hb (P < 0.05), respectively). It was also found that females had higher erythrocyte GPx activity than males but this difference did not reach significance in non-smokers. Conclusion: From the results of this study it is concluded that oxidative stress seems to be present in elderly ever-smokers among the Chinese population.
Persistent Identifierhttp://hdl.handle.net/10722/162866
ISSN
2015 Impact Factor: 3.078
2015 SCImago Journal Rankings: 1.157
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorHo, SPen_US
dc.contributor.authorChanYeung, Men_US
dc.contributor.authorChow, KKMen_US
dc.contributor.authorIp, MSMen_US
dc.contributor.authorMak, JCWen_US
dc.date.accessioned2012-09-05T05:24:34Z-
dc.date.available2012-09-05T05:24:34Z-
dc.date.issued2005en_US
dc.identifier.citationRespirology, 2005, v. 10 n. 3, p. 305-309en_US
dc.identifier.issn1323-7799en_US
dc.identifier.urihttp://hdl.handle.net/10722/162866-
dc.description.abstractObjective: Specific antioxidant enzymes play a vital role in regulating and maintaining oxidant species. The aim of this study was to determine these antioxidant enzyme activities (i.e. catalase (CAT), superoxide dismutase (SOD) and glutathione peroxidase (GPx)) in erythrocytes from a group of healthy Chinese subjects and to study the influence of age, gender and smoking habits on the enzyme activities. Methodology: Chinese healthy subjects (n = 276) were grouped according to their age range, gender differences and smoking habits. Antioxidant enzyme activities were measured spectrophotometrically using standard kinetic methods. Results: There was a significant decrease in erythrocyte GPx activity in ever-smokers compared with non-smokers (47.10 ± 1.33 mU/g haemoglobin (Hb) vs. 51.41 ± 1.64 mU/g Hb, P < 0.05). Age-related significant increases in erythrocyte CAT and SOD activities were found in non-smokers but not in ever-smokers. There was no age-related difference in erythrocyte GPx activity in either non-smokers or ever-smokers. Among those >60 years old, erythrocyte CAT and GPx activities were significantly lower in ever-smokers than in non-smokers (29.70 ± 3.07 mU/g Hb vs. 41.63 ± 4.92 mU/g Hb (P < 0.05), and 47.55 ± 2.00 mU/g Hb vs. 55.30 ± 3.60 mU/g Hb (P < 0.05), respectively). It was also found that females had higher erythrocyte GPx activity than males but this difference did not reach significance in non-smokers. Conclusion: From the results of this study it is concluded that oxidative stress seems to be present in elderly ever-smokers among the Chinese population.en_US
dc.languageengen_US
dc.publisherBlackwell Publishing Asia. The Journal's web site is located at http://www.blackwellpublishing.com/journals/RESen_US
dc.relation.ispartofRespirologyen_US
dc.subject.meshAdolescenten_US
dc.subject.meshAdulten_US
dc.subject.meshAge Factorsen_US
dc.subject.meshAgeden_US
dc.subject.meshAged, 80 And Overen_US
dc.subject.meshAsian Continental Ancestry Groupen_US
dc.subject.meshCatalase - Blooden_US
dc.subject.meshFemaleen_US
dc.subject.meshGlutathione Peroxidase - Blooden_US
dc.subject.meshHong Kongen_US
dc.subject.meshHumansen_US
dc.subject.meshMaleen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshOxidative Stress - Physiologyen_US
dc.subject.meshReference Valuesen_US
dc.subject.meshRetrospective Studiesen_US
dc.subject.meshSex Factorsen_US
dc.subject.meshSmoking - Blooden_US
dc.subject.meshSpectrophotometryen_US
dc.subject.meshSuperoxide Dismutase - Blooden_US
dc.titleAntioxidant enzyme activities in healthy Chinese adults: Influence of age, gender and smokingen_US
dc.typeArticleen_US
dc.identifier.emailIp, MSM:msmip@hku.hken_US
dc.identifier.emailMak, JCW:judymak@hku.hken_US
dc.identifier.authorityIp, MSM=rp00347en_US
dc.identifier.authorityMak, JCW=rp00352en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1111/j.1440-1843.2005.00702.xen_US
dc.identifier.pmid15955142-
dc.identifier.scopuseid_2-s2.0-22644432498en_US
dc.identifier.hkuros98138-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-22644432498&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume10en_US
dc.identifier.issue3en_US
dc.identifier.spage305en_US
dc.identifier.epage309en_US
dc.identifier.isiWOS:000230551100006-
dc.publisher.placeAustraliaen_US
dc.identifier.scopusauthoridHo, SP=12794365900en_US
dc.identifier.scopusauthoridChanYeung, M=54790582200en_US
dc.identifier.scopusauthoridChow, KKM=8628234700en_US
dc.identifier.scopusauthoridIp, MSM=7102423259en_US
dc.identifier.scopusauthoridMak, JCW=7103323094en_US
dc.identifier.citeulike217727-

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