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Article: Molecular epidemiology of follicular lymphoma in Chinese: Relationship with bcl-2/IgH translocation and bcl-6 397G/C polymorphism

TitleMolecular epidemiology of follicular lymphoma in Chinese: Relationship with bcl-2/IgH translocation and bcl-6 397G/C polymorphism
Authors
Issue Date2005
PublisherSpringer Verlag. The Journal's web site is located at http://link.springer.de/link/service/journals/00277/index.htm
Citation
Annals Of Hematology, 2005, v. 84 n. 8, p. 506-509 How to Cite?
AbstractThe relative incidence of follicular lymphoma (FL) compared with diffuse large B-cell lymphoma (DLCL) is low in Chinese. This may be due to a lower incidence of t(14;18)-mediated disease, a rapid transformation of FL to DLCL, or a lower incidence of FL-prone genetic polymorphisms (e.g., bcl-6 G397C). Using a conventional and long-distance polymerase chain reaction technique, we showed that 93% (43/46) of Chinese FL cases are t(14;18) related and are molecularly indistinguishable from Caucasian cases. The translocation was uncommonly found in Chinese DLCL cases (8/58, 14%). Furthermore, the incidence of bcl-6 hypermutation in FL and DLCL cases appeared to be comparable. These data do not suggest a high incidence of transformation from FL to DLCL in Chinese. Sequencing study also did not show an increased incidence of G397C polymorphism (heterozygote+homozygotes) in FL compared to a population with Chinese background or DLCL cases (25+5% vs 30+4% vs 22+3%). The reasons for the lower incidence of FL in Chinese remain unanswered. © Springer-Verlag 2005.
Persistent Identifierhttp://hdl.handle.net/10722/162864
ISSN
2015 Impact Factor: 3.022
2015 SCImago Journal Rankings: 1.117
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorAu, WYen_US
dc.contributor.authorFung, Aen_US
dc.contributor.authorLiang, Ren_US
dc.date.accessioned2012-09-05T05:24:33Z-
dc.date.available2012-09-05T05:24:33Z-
dc.date.issued2005en_US
dc.identifier.citationAnnals Of Hematology, 2005, v. 84 n. 8, p. 506-509en_US
dc.identifier.issn0939-5555en_US
dc.identifier.urihttp://hdl.handle.net/10722/162864-
dc.description.abstractThe relative incidence of follicular lymphoma (FL) compared with diffuse large B-cell lymphoma (DLCL) is low in Chinese. This may be due to a lower incidence of t(14;18)-mediated disease, a rapid transformation of FL to DLCL, or a lower incidence of FL-prone genetic polymorphisms (e.g., bcl-6 G397C). Using a conventional and long-distance polymerase chain reaction technique, we showed that 93% (43/46) of Chinese FL cases are t(14;18) related and are molecularly indistinguishable from Caucasian cases. The translocation was uncommonly found in Chinese DLCL cases (8/58, 14%). Furthermore, the incidence of bcl-6 hypermutation in FL and DLCL cases appeared to be comparable. These data do not suggest a high incidence of transformation from FL to DLCL in Chinese. Sequencing study also did not show an increased incidence of G397C polymorphism (heterozygote+homozygotes) in FL compared to a population with Chinese background or DLCL cases (25+5% vs 30+4% vs 22+3%). The reasons for the lower incidence of FL in Chinese remain unanswered. © Springer-Verlag 2005.en_US
dc.languageengen_US
dc.publisherSpringer Verlag. The Journal's web site is located at http://link.springer.de/link/service/journals/00277/index.htmen_US
dc.relation.ispartofAnnals of Hematologyen_US
dc.subject.meshAdulten_US
dc.subject.meshAgeden_US
dc.subject.meshAged, 80 And Overen_US
dc.subject.meshChina - Epidemiologyen_US
dc.subject.meshDna-Binding Proteins - Geneticsen_US
dc.subject.meshFemaleen_US
dc.subject.meshGenes, Bcl-2 - Geneticsen_US
dc.subject.meshHumansen_US
dc.subject.meshImmunoglobulin Heavy Chains - Geneticsen_US
dc.subject.meshIncidenceen_US
dc.subject.meshLymphoma, Follicular - Epidemiology - Geneticsen_US
dc.subject.meshLymphoma, Large B-Cell, Diffuse - Etiology - Pathologyen_US
dc.subject.meshMaleen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshMolecular Epidemiologyen_US
dc.subject.meshPolymorphism, Single Nucleotideen_US
dc.subject.meshTranslocation, Geneticen_US
dc.titleMolecular epidemiology of follicular lymphoma in Chinese: Relationship with bcl-2/IgH translocation and bcl-6 397G/C polymorphismen_US
dc.typeArticleen_US
dc.identifier.emailLiang, R:rliang@hku.hken_US
dc.identifier.authorityLiang, R=rp00345en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1007/s00277-005-1028-2en_US
dc.identifier.pmid15875184-
dc.identifier.scopuseid_2-s2.0-22344446749en_US
dc.identifier.hkuros120304-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-22344446749&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume84en_US
dc.identifier.issue8en_US
dc.identifier.spage506en_US
dc.identifier.epage509en_US
dc.identifier.isiWOS:000230316400003-
dc.publisher.placeGermanyen_US
dc.identifier.scopusauthoridAu, WY=7202383089en_US
dc.identifier.scopusauthoridFung, A=7101926728en_US
dc.identifier.scopusauthoridLiang, R=26643224900en_US

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