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Article: Inhibition of gastric cancer-associated angiogenesis by antisense COX-2 transfectants

TitleInhibition of gastric cancer-associated angiogenesis by antisense COX-2 transfectants
Authors
Issue Date2005
PublisherElsevier Ireland Ltd. The Journal's web site is located at http://www.elsevier.com/locate/canlet
Citation
Cancer Letters, 2005, v. 224 n. 2, p. 243-252 How to Cite?
AbstractWe characterized the effects of selective Cox-2 inhibition on the angiogenesis gastric cancer cell line SGC7901 by stable transfection of antisense Cox-2 cDNA (Cox-2-AS) or pharmacological inhibition by selective cox-2 inhibitor (NS398). The conditioned media obtained from SGC7901 treated with Cox-2-AS or NS398 suppressed the proliferation, migration and tube formation of human umbilical vein endothelial cells. Moreover, both treatments inhibited in vivo angiogenesis. These inhibitions could be partially reversed by the addition of PGE2. Our findings support that selective inhibition of Cox-2 alone plays an instrumental role on gastric cancer associated angiogenesis. © 2004 Elsevier Ireland Ltd. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/162855
ISSN
2015 Impact Factor: 5.992
2015 SCImago Journal Rankings: 2.331
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorFu, YGen_US
dc.contributor.authorSung, JJYen_US
dc.contributor.authorWu, KCen_US
dc.contributor.authorWu, HPen_US
dc.contributor.authorYu, Jen_US
dc.contributor.authorChan, Men_US
dc.contributor.authorChan, VYWen_US
dc.contributor.authorChan, KKen_US
dc.contributor.authorFan, DMen_US
dc.contributor.authorLeung, WKen_US
dc.date.accessioned2012-09-05T05:24:28Z-
dc.date.available2012-09-05T05:24:28Z-
dc.date.issued2005en_US
dc.identifier.citationCancer Letters, 2005, v. 224 n. 2, p. 243-252en_US
dc.identifier.issn0304-3835en_US
dc.identifier.urihttp://hdl.handle.net/10722/162855-
dc.description.abstractWe characterized the effects of selective Cox-2 inhibition on the angiogenesis gastric cancer cell line SGC7901 by stable transfection of antisense Cox-2 cDNA (Cox-2-AS) or pharmacological inhibition by selective cox-2 inhibitor (NS398). The conditioned media obtained from SGC7901 treated with Cox-2-AS or NS398 suppressed the proliferation, migration and tube formation of human umbilical vein endothelial cells. Moreover, both treatments inhibited in vivo angiogenesis. These inhibitions could be partially reversed by the addition of PGE2. Our findings support that selective inhibition of Cox-2 alone plays an instrumental role on gastric cancer associated angiogenesis. © 2004 Elsevier Ireland Ltd. All rights reserved.en_US
dc.languageengen_US
dc.publisherElsevier Ireland Ltd. The Journal's web site is located at http://www.elsevier.com/locate/canleten_US
dc.relation.ispartofCancer Lettersen_US
dc.subject.meshCyclooxygenase 2en_US
dc.subject.meshCyclooxygenase 2 Inhibitorsen_US
dc.subject.meshCyclooxygenase Inhibitors - Pharmacologyen_US
dc.subject.meshDna, Antisenseen_US
dc.subject.meshDna, Complementaryen_US
dc.subject.meshHumansen_US
dc.subject.meshMembrane Proteinsen_US
dc.subject.meshNeovascularization, Pathologicen_US
dc.subject.meshNitrobenzenes - Pharmacologyen_US
dc.subject.meshProstaglandin-Endoperoxide Synthases - Genetics - Metabolismen_US
dc.subject.meshStomach Neoplasms - Pathologyen_US
dc.subject.meshSulfonamides - Pharmacologyen_US
dc.subject.meshTransfectionen_US
dc.subject.meshTumor Cells, Cultureden_US
dc.titleInhibition of gastric cancer-associated angiogenesis by antisense COX-2 transfectantsen_US
dc.typeArticleen_US
dc.identifier.emailLeung, WK:waikleung@hku.hken_US
dc.identifier.authorityLeung, WK=rp01479en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1016/j.canlet.2004.11.038en_US
dc.identifier.pmid15914275en_US
dc.identifier.scopuseid_2-s2.0-21144457216en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-21144457216&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume224en_US
dc.identifier.issue2en_US
dc.identifier.spage243en_US
dc.identifier.epage252en_US
dc.identifier.isiWOS:000229850900008-
dc.publisher.placeIrelanden_US
dc.identifier.scopusauthoridFu, YG=8599738000en_US
dc.identifier.scopusauthoridSung, JJY=35405352400en_US
dc.identifier.scopusauthoridWu, KC=8947728400en_US
dc.identifier.scopusauthoridWu, HP=7405582418en_US
dc.identifier.scopusauthoridYu, J=35351306800en_US
dc.identifier.scopusauthoridChan, M=36941299700en_US
dc.identifier.scopusauthoridChan, VYW=8599737600en_US
dc.identifier.scopusauthoridChan, KK=8599737700en_US
dc.identifier.scopusauthoridFan, DM=7202965595en_US
dc.identifier.scopusauthoridLeung, WK=7201504523en_US

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