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Article: Long-term outcome of Helicobacter pylori-negative idiopathic bleeding ulcers: A prospective cohort study
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TitleLong-term outcome of Helicobacter pylori-negative idiopathic bleeding ulcers: A prospective cohort study
 
AuthorsHung, LCT1
Ching, JYL1
Sung, JJY1
To, KF1
Hui, AJ1
Wong, VWS1
Leong, RWL2
Chan, HLY1
Wu, JCY1
Leung, WK1
Lee, YT1
Chung, SCS1
Chan, FKL1
 
Issue Date2005
 
PublisherWB Saunders Co. The Journal's web site is located at http://www.elsevier.com/locate/gastro
 
CitationGastroenterology, 2005, v. 128 n. 7, p. 1845-1850 [How to Cite?]
DOI: http://dx.doi.org/10.1053/j.gastro.2005.03.026
 
AbstractBackground & Aims: Helicobacter pylori-negative idiopathic ulcers are increasingly recognized. The secular trend and long-term outcome of this condition are unknown. Methods: We prospectively studied consecutive patients with bleeding gastroduodenal ulcers from January to December 2000. The incidence and etiology of ulcers during this period were compared with that between September 1997 and August 1998. H pylori-negative idiopathic ulcers were defined as negative tests for H pylori, no exposure to analgesics within 4 weeks, and absence of other risk factors for ulcers. After the ulcers had healed, patients with H pylori-negative idiopathic ulcers and patients with H pylori ulcers who received eradication therapy were followed up for 12 months without anti-ulcer drugs. Results: Six hundred thirty-eight patients had bleeding ulcers: 213 (33.4%) were H pylori ulcers, and 120 (18.8%) were H pylori-negative idiopathic ulcers (vs 480 [50.3%] H pylori ulcers and 40 [4.2%] H pylori-negative idiopathic ulcers in 1997-1998; P <. 001). H pylori-negative idiopathic ulcers accounted for 16.1% of patients who were admitted for bleeding and 42.4% of patients who bled while in the hospital (P <. 0001); 28.3% of patients with H pylori-negative idiopathic ulcers had histologic evidence of past H pylori infection. The probability of recurrent ulcer complications in 12 months was 13.4% (95% CI: 7.3%-19.5%) in patients with H pylori-negative idiopathic ulcers and 2.5% (95% CI: 0.4%-4.6%) in patients with H pylori ulcers who received eradication therapy (P =. 0002). Conclusions: The incidence of H pylori-negative idiopathic bleeding ulcers is rising. These ulcers are prone to recurrent complications. © 2005 by the American Gastroenterological Association.
 
ISSN0016-5085
2012 Impact Factor: 12.821
2012 SCImago Journal Rankings: 3.649
 
DOIhttp://dx.doi.org/10.1053/j.gastro.2005.03.026
 
ReferencesReferences in Scopus
 
DC FieldValue
dc.contributor.authorHung, LCT
 
dc.contributor.authorChing, JYL
 
dc.contributor.authorSung, JJY
 
dc.contributor.authorTo, KF
 
dc.contributor.authorHui, AJ
 
dc.contributor.authorWong, VWS
 
dc.contributor.authorLeong, RWL
 
dc.contributor.authorChan, HLY
 
dc.contributor.authorWu, JCY
 
dc.contributor.authorLeung, WK
 
dc.contributor.authorLee, YT
 
dc.contributor.authorChung, SCS
 
dc.contributor.authorChan, FKL
 
dc.date.accessioned2012-09-05T05:24:25Z
 
dc.date.available2012-09-05T05:24:25Z
 
dc.date.issued2005
 
dc.description.abstractBackground & Aims: Helicobacter pylori-negative idiopathic ulcers are increasingly recognized. The secular trend and long-term outcome of this condition are unknown. Methods: We prospectively studied consecutive patients with bleeding gastroduodenal ulcers from January to December 2000. The incidence and etiology of ulcers during this period were compared with that between September 1997 and August 1998. H pylori-negative idiopathic ulcers were defined as negative tests for H pylori, no exposure to analgesics within 4 weeks, and absence of other risk factors for ulcers. After the ulcers had healed, patients with H pylori-negative idiopathic ulcers and patients with H pylori ulcers who received eradication therapy were followed up for 12 months without anti-ulcer drugs. Results: Six hundred thirty-eight patients had bleeding ulcers: 213 (33.4%) were H pylori ulcers, and 120 (18.8%) were H pylori-negative idiopathic ulcers (vs 480 [50.3%] H pylori ulcers and 40 [4.2%] H pylori-negative idiopathic ulcers in 1997-1998; P <. 001). H pylori-negative idiopathic ulcers accounted for 16.1% of patients who were admitted for bleeding and 42.4% of patients who bled while in the hospital (P <. 0001); 28.3% of patients with H pylori-negative idiopathic ulcers had histologic evidence of past H pylori infection. The probability of recurrent ulcer complications in 12 months was 13.4% (95% CI: 7.3%-19.5%) in patients with H pylori-negative idiopathic ulcers and 2.5% (95% CI: 0.4%-4.6%) in patients with H pylori ulcers who received eradication therapy (P =. 0002). Conclusions: The incidence of H pylori-negative idiopathic bleeding ulcers is rising. These ulcers are prone to recurrent complications. © 2005 by the American Gastroenterological Association.
 
dc.description.natureLink_to_subscribed_fulltext
 
dc.identifier.citationGastroenterology, 2005, v. 128 n. 7, p. 1845-1850 [How to Cite?]
DOI: http://dx.doi.org/10.1053/j.gastro.2005.03.026
 
dc.identifier.doihttp://dx.doi.org/10.1053/j.gastro.2005.03.026
 
dc.identifier.epage1850
 
dc.identifier.issn0016-5085
2012 Impact Factor: 12.821
2012 SCImago Journal Rankings: 3.649
 
dc.identifier.issue7
 
dc.identifier.pmid15940620
 
dc.identifier.scopuseid_2-s2.0-20444502452
 
dc.identifier.spage1845
 
dc.identifier.urihttp://hdl.handle.net/10722/162852
 
dc.identifier.volume128
 
dc.languageeng
 
dc.publisherWB Saunders Co. The Journal's web site is located at http://www.elsevier.com/locate/gastro
 
dc.publisher.placeUnited States
 
dc.relation.ispartofGastroenterology
 
dc.relation.referencesReferences in Scopus
 
dc.subject.meshAdult
 
dc.subject.meshAged
 
dc.subject.meshAged, 80 And Over
 
dc.subject.meshDuodenal Ulcer - Complications - Epidemiology - Pathology
 
dc.subject.meshFemale
 
dc.subject.meshGastrointestinal Hemorrhage - Etiology
 
dc.subject.meshHelicobacter Pylori
 
dc.subject.meshHumans
 
dc.subject.meshIncidence
 
dc.subject.meshMale
 
dc.subject.meshMiddle Aged
 
dc.subject.meshPrognosis
 
dc.subject.meshProspective Studies
 
dc.subject.meshRecurrence
 
dc.subject.meshStomach Ulcer - Complications - Epidemiology - Pathology
 
dc.titleLong-term outcome of Helicobacter pylori-negative idiopathic bleeding ulcers: A prospective cohort study
 
dc.typeArticle
 
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<contributor.author>To, KF</contributor.author>
<contributor.author>Hui, AJ</contributor.author>
<contributor.author>Wong, VWS</contributor.author>
<contributor.author>Leong, RWL</contributor.author>
<contributor.author>Chan, HLY</contributor.author>
<contributor.author>Wu, JCY</contributor.author>
<contributor.author>Leung, WK</contributor.author>
<contributor.author>Lee, YT</contributor.author>
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<contributor.author>Chan, FKL</contributor.author>
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<description.abstract>Background &amp; Aims: Helicobacter pylori-negative idiopathic ulcers are increasingly recognized. The secular trend and long-term outcome of this condition are unknown. Methods: We prospectively studied consecutive patients with bleeding gastroduodenal ulcers from January to December 2000. The incidence and etiology of ulcers during this period were compared with that between September 1997 and August 1998. H pylori-negative idiopathic ulcers were defined as negative tests for H pylori, no exposure to analgesics within 4 weeks, and absence of other risk factors for ulcers. After the ulcers had healed, patients with H pylori-negative idiopathic ulcers and patients with H pylori ulcers who received eradication therapy were followed up for 12 months without anti-ulcer drugs. Results: Six hundred thirty-eight patients had bleeding ulcers: 213 (33.4%) were H pylori ulcers, and 120 (18.8%) were H pylori-negative idiopathic ulcers (vs 480 [50.3%] H pylori ulcers and 40 [4.2%] H pylori-negative idiopathic ulcers in 1997-1998; P &lt;. 001). H pylori-negative idiopathic ulcers accounted for 16.1% of patients who were admitted for bleeding and 42.4% of patients who bled while in the hospital (P &lt;. 0001); 28.3% of patients with H pylori-negative idiopathic ulcers had histologic evidence of past H pylori infection. The probability of recurrent ulcer complications in 12 months was 13.4% (95% CI: 7.3%-19.5%) in patients with H pylori-negative idiopathic ulcers and 2.5% (95% CI: 0.4%-4.6%) in patients with H pylori ulcers who received eradication therapy (P =. 0002). Conclusions: The incidence of H pylori-negative idiopathic bleeding ulcers is rising. These ulcers are prone to recurrent complications. &#169; 2005 by the American Gastroenterological Association.</description.abstract>
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Author Affiliations
  1. Prince of Wales Hospital Hong Kong
  2. University of New South Wales