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Article: Standard treatment for Helicobacter pylori infection is suboptimal in non-ulcer dyspepsia compared with duodenal ulcer in Chinese

TitleStandard treatment for Helicobacter pylori infection is suboptimal in non-ulcer dyspepsia compared with duodenal ulcer in Chinese
Authors
Issue Date2005
PublisherBlackwell Publishing Ltd. The Journal's web site is located at http://www.blackwellpublishing.com/journals/APT
Citation
Alimentary Pharmacology And Therapeutics, 2005, v. 21 n. 1, p. 73-81 How to Cite?
Abstract
Background: Recent studies suggest that the Helicobacter pylori eradication rate in patients with non-ulcer dyspepsia is lower when compared to patients with peptic ulcer diseases. Aim: The aim of this study was to study the efficacy of triple therapy for H. pylori infection in patients with duodenal ulcer vs. patients with non-ulcer dyspepsia. Methods: A total of 582 Chinese patients with proven H. pylori infection were recruited to receive: omeprazole 20 mg, amoxicillin 1000 mg and clarithromycin 500 mg all given twice daily for 7 days (OCA regime). Endoscopy with rapid urease test, histology and culture were performed before treatment. Post-treatment H. pylori status was determined by 13C-urea breath test. Metronidazole, clarithromycin and amoxicillin resistance was defined as minimum inhibitory concentration (MIC) of >8 μg/mL, >1 μg/mL and >1 μg/mL, respectively. Results: A significantly higher (intention-to-treat/per-protocol) eradication rate was found in patients with duodenal ulcer than those with non-ulcer dyspepsia (91/94% vs. 84/88% respectively, P = 0.011 and P = 0.016). Clarithromycin resistance rate was higher in patients with non-ulcer dyspepsia than those with duodenal ulcer (14% vs. 6%, P = 0.015). Clarithromycin resistance (40% vs. 5%, P < 0.001, OR 12. 95% CI: 5.7-24.3) and the diagnosis of non-ulcer dyspepsia (91% vs. 84%, P = 0.011. OR 2.0. 95% CI: 1.2-3.3) significantly affected the success of H. pylori eradication. Conclusion: Clarithromycin resistance accounts for the significantly lower and suboptimal H. pylori eradication rate of OCA regimen in Chinese patients with non-ulcer dyspepsia compared to those with duodenal ulcer.
Persistent Identifierhttp://hdl.handle.net/10722/162851
ISSN
2013 Impact Factor: 5.478
2013 SCImago Journal Rankings: 2.609
ISI Accession Number ID
References

 

Author Affiliations
  1. The University of Hong Kong
  2. Shanghai Second Medical University
  3. Sun Yat Sen University of Medical Sciences
DC FieldValueLanguage
dc.contributor.authorWong, WMen_US
dc.contributor.authorXiao, SDen_US
dc.contributor.authorHu, PJen_US
dc.contributor.authorWang, WHen_US
dc.contributor.authorGu, Qen_US
dc.contributor.authorHuang, JQen_US
dc.contributor.authorXia, HHXen_US
dc.contributor.authorWu, SMen_US
dc.contributor.authorLi, CJen_US
dc.contributor.authorChen, MHen_US
dc.contributor.authorCui, Yen_US
dc.contributor.authorLai, KCen_US
dc.contributor.authorHu, WHCen_US
dc.contributor.authorChan, CKen_US
dc.contributor.authorLam, SKen_US
dc.contributor.authorWong, BCYen_US
dc.date.accessioned2012-09-05T05:24:24Z-
dc.date.available2012-09-05T05:24:24Z-
dc.date.issued2005en_US
dc.identifier.citationAlimentary Pharmacology And Therapeutics, 2005, v. 21 n. 1, p. 73-81en_US
dc.identifier.issn0269-2813en_US
dc.identifier.urihttp://hdl.handle.net/10722/162851-
dc.description.abstractBackground: Recent studies suggest that the Helicobacter pylori eradication rate in patients with non-ulcer dyspepsia is lower when compared to patients with peptic ulcer diseases. Aim: The aim of this study was to study the efficacy of triple therapy for H. pylori infection in patients with duodenal ulcer vs. patients with non-ulcer dyspepsia. Methods: A total of 582 Chinese patients with proven H. pylori infection were recruited to receive: omeprazole 20 mg, amoxicillin 1000 mg and clarithromycin 500 mg all given twice daily for 7 days (OCA regime). Endoscopy with rapid urease test, histology and culture were performed before treatment. Post-treatment H. pylori status was determined by 13C-urea breath test. Metronidazole, clarithromycin and amoxicillin resistance was defined as minimum inhibitory concentration (MIC) of >8 μg/mL, >1 μg/mL and >1 μg/mL, respectively. Results: A significantly higher (intention-to-treat/per-protocol) eradication rate was found in patients with duodenal ulcer than those with non-ulcer dyspepsia (91/94% vs. 84/88% respectively, P = 0.011 and P = 0.016). Clarithromycin resistance rate was higher in patients with non-ulcer dyspepsia than those with duodenal ulcer (14% vs. 6%, P = 0.015). Clarithromycin resistance (40% vs. 5%, P < 0.001, OR 12. 95% CI: 5.7-24.3) and the diagnosis of non-ulcer dyspepsia (91% vs. 84%, P = 0.011. OR 2.0. 95% CI: 1.2-3.3) significantly affected the success of H. pylori eradication. Conclusion: Clarithromycin resistance accounts for the significantly lower and suboptimal H. pylori eradication rate of OCA regimen in Chinese patients with non-ulcer dyspepsia compared to those with duodenal ulcer.en_US
dc.languageengen_US
dc.publisherBlackwell Publishing Ltd. The Journal's web site is located at http://www.blackwellpublishing.com/journals/APTen_US
dc.relation.ispartofAlimentary Pharmacology and Therapeuticsen_US
dc.rightsAlimentary Pharmacology and Therapeutics. Copyright © Blackwell Publishing Ltd.-
dc.subject.meshAdolescenten_US
dc.subject.meshAdulten_US
dc.subject.meshAgeden_US
dc.subject.meshAmoxicillin - Therapeutic Useen_US
dc.subject.meshAnti-Ulcer Agents - Therapeutic Useen_US
dc.subject.meshAsian Continental Ancestry Group - Ethnologyen_US
dc.subject.meshClarithromycin - Therapeutic Useen_US
dc.subject.meshDrug Resistanceen_US
dc.subject.meshDrug Therapy, Combination - Therapeutic Useen_US
dc.subject.meshDuodenal Ulcer - Ethnology - Microbiologyen_US
dc.subject.meshDyspepsia - Ethnology - Microbiologyen_US
dc.subject.meshFemaleen_US
dc.subject.meshHelicobacter Infections - Drug Therapy - Ethnologyen_US
dc.subject.meshHelicobacter Pylorien_US
dc.subject.meshHumansen_US
dc.subject.meshMaleen_US
dc.subject.meshMetronidazole - Therapeutic Useen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshOmeprazole - Therapeutic Useen_US
dc.subject.meshPatient Complianceen_US
dc.subject.meshTreatment Outcomeen_US
dc.titleStandard treatment for Helicobacter pylori infection is suboptimal in non-ulcer dyspepsia compared with duodenal ulcer in Chineseen_US
dc.typeArticleen_US
dc.identifier.emailWong, BCY:bcywong@hku.hken_US
dc.identifier.authorityWong, BCY=rp00429en_US
dc.description.naturelink_to_OA_fulltexten_US
dc.identifier.doi10.1111/j.1365-2036.2004.02283.xen_US
dc.identifier.pmid15644048en_US
dc.identifier.scopuseid_2-s2.0-20244380121en_US
dc.identifier.hkuros97002-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-20244380121&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume21en_US
dc.identifier.issue1en_US
dc.identifier.spage73en_US
dc.identifier.epage81en_US
dc.identifier.isiWOS:000226333900010-
dc.publisher.placeUnited Kingdomen_US
dc.identifier.scopusauthoridWong, WM=7403972413en_US
dc.identifier.scopusauthoridXiao, SD=12780231400en_US
dc.identifier.scopusauthoridHu, PJ=7201989582en_US
dc.identifier.scopusauthoridWang, WH=23390847100en_US
dc.identifier.scopusauthoridGu, Q=24469982400en_US
dc.identifier.scopusauthoridHuang, JQ=7403635051en_US
dc.identifier.scopusauthoridXia, HHX=8757161400en_US
dc.identifier.scopusauthoridWu, SM=15764046700en_US
dc.identifier.scopusauthoridLi, CJ=36078361000en_US
dc.identifier.scopusauthoridChen, MH=8642044500en_US
dc.identifier.scopusauthoridCui, Y=35200410400en_US
dc.identifier.scopusauthoridLai, KC=7402135595en_US
dc.identifier.scopusauthoridHu, WHC=25932937100en_US
dc.identifier.scopusauthoridChan, CK=7404813824en_US
dc.identifier.scopusauthoridLam, SK=7402279473en_US
dc.identifier.scopusauthoridWong, BCY=7402023340en_US
dc.identifier.citeulike74115-

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