File Download
  Links for fulltext
     (May Require Subscription)
Supplementary

Article: Standard treatment for Helicobacter pylori infection is suboptimal in non-ulcer dyspepsia compared with duodenal ulcer in Chinese

TitleStandard treatment for Helicobacter pylori infection is suboptimal in non-ulcer dyspepsia compared with duodenal ulcer in Chinese
Authors
Issue Date2005
PublisherBlackwell Publishing Ltd. The Journal's web site is located at http://www.blackwellpublishing.com/journals/APT
Citation
Alimentary Pharmacology And Therapeutics, 2005, v. 21 n. 1, p. 73-81 How to Cite?
AbstractBackground: Recent studies suggest that the Helicobacter pylori eradication rate in patients with non-ulcer dyspepsia is lower when compared to patients with peptic ulcer diseases. Aim: The aim of this study was to study the efficacy of triple therapy for H. pylori infection in patients with duodenal ulcer vs. patients with non-ulcer dyspepsia. Methods: A total of 582 Chinese patients with proven H. pylori infection were recruited to receive: omeprazole 20 mg, amoxicillin 1000 mg and clarithromycin 500 mg all given twice daily for 7 days (OCA regime). Endoscopy with rapid urease test, histology and culture were performed before treatment. Post-treatment H. pylori status was determined by 13C-urea breath test. Metronidazole, clarithromycin and amoxicillin resistance was defined as minimum inhibitory concentration (MIC) of >8 μg/mL, >1 μg/mL and >1 μg/mL, respectively. Results: A significantly higher (intention-to-treat/per-protocol) eradication rate was found in patients with duodenal ulcer than those with non-ulcer dyspepsia (91/94% vs. 84/88% respectively, P = 0.011 and P = 0.016). Clarithromycin resistance rate was higher in patients with non-ulcer dyspepsia than those with duodenal ulcer (14% vs. 6%, P = 0.015). Clarithromycin resistance (40% vs. 5%, P < 0.001, OR 12. 95% CI: 5.7-24.3) and the diagnosis of non-ulcer dyspepsia (91% vs. 84%, P = 0.011. OR 2.0. 95% CI: 1.2-3.3) significantly affected the success of H. pylori eradication. Conclusion: Clarithromycin resistance accounts for the significantly lower and suboptimal H. pylori eradication rate of OCA regimen in Chinese patients with non-ulcer dyspepsia compared to those with duodenal ulcer.
Persistent Identifierhttp://hdl.handle.net/10722/162851
ISSN
2021 Impact Factor: 9.524
2020 SCImago Journal Rankings: 3.308
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorWong, WMen_US
dc.contributor.authorXiao, SDen_US
dc.contributor.authorHu, PJen_US
dc.contributor.authorWang, WHen_US
dc.contributor.authorGu, Qen_US
dc.contributor.authorHuang, JQen_US
dc.contributor.authorXia, HHXen_US
dc.contributor.authorWu, SMen_US
dc.contributor.authorLi, CJen_US
dc.contributor.authorChen, MHen_US
dc.contributor.authorCui, Yen_US
dc.contributor.authorLai, KCen_US
dc.contributor.authorHu, WHCen_US
dc.contributor.authorChan, CKen_US
dc.contributor.authorLam, SKen_US
dc.contributor.authorWong, BCYen_US
dc.date.accessioned2012-09-05T05:24:24Z-
dc.date.available2012-09-05T05:24:24Z-
dc.date.issued2005en_US
dc.identifier.citationAlimentary Pharmacology And Therapeutics, 2005, v. 21 n. 1, p. 73-81en_US
dc.identifier.issn0269-2813en_US
dc.identifier.urihttp://hdl.handle.net/10722/162851-
dc.description.abstractBackground: Recent studies suggest that the Helicobacter pylori eradication rate in patients with non-ulcer dyspepsia is lower when compared to patients with peptic ulcer diseases. Aim: The aim of this study was to study the efficacy of triple therapy for H. pylori infection in patients with duodenal ulcer vs. patients with non-ulcer dyspepsia. Methods: A total of 582 Chinese patients with proven H. pylori infection were recruited to receive: omeprazole 20 mg, amoxicillin 1000 mg and clarithromycin 500 mg all given twice daily for 7 days (OCA regime). Endoscopy with rapid urease test, histology and culture were performed before treatment. Post-treatment H. pylori status was determined by 13C-urea breath test. Metronidazole, clarithromycin and amoxicillin resistance was defined as minimum inhibitory concentration (MIC) of >8 μg/mL, >1 μg/mL and >1 μg/mL, respectively. Results: A significantly higher (intention-to-treat/per-protocol) eradication rate was found in patients with duodenal ulcer than those with non-ulcer dyspepsia (91/94% vs. 84/88% respectively, P = 0.011 and P = 0.016). Clarithromycin resistance rate was higher in patients with non-ulcer dyspepsia than those with duodenal ulcer (14% vs. 6%, P = 0.015). Clarithromycin resistance (40% vs. 5%, P < 0.001, OR 12. 95% CI: 5.7-24.3) and the diagnosis of non-ulcer dyspepsia (91% vs. 84%, P = 0.011. OR 2.0. 95% CI: 1.2-3.3) significantly affected the success of H. pylori eradication. Conclusion: Clarithromycin resistance accounts for the significantly lower and suboptimal H. pylori eradication rate of OCA regimen in Chinese patients with non-ulcer dyspepsia compared to those with duodenal ulcer.en_US
dc.languageengen_US
dc.publisherBlackwell Publishing Ltd. The Journal's web site is located at http://www.blackwellpublishing.com/journals/APTen_US
dc.relation.ispartofAlimentary Pharmacology and Therapeuticsen_US
dc.rightsAlimentary Pharmacology and Therapeutics. Copyright © Blackwell Publishing Ltd.-
dc.subject.meshAdolescenten_US
dc.subject.meshAdulten_US
dc.subject.meshAgeden_US
dc.subject.meshAmoxicillin - Therapeutic Useen_US
dc.subject.meshAnti-Ulcer Agents - Therapeutic Useen_US
dc.subject.meshAsian Continental Ancestry Group - Ethnologyen_US
dc.subject.meshClarithromycin - Therapeutic Useen_US
dc.subject.meshDrug Resistanceen_US
dc.subject.meshDrug Therapy, Combination - Therapeutic Useen_US
dc.subject.meshDuodenal Ulcer - Ethnology - Microbiologyen_US
dc.subject.meshDyspepsia - Ethnology - Microbiologyen_US
dc.subject.meshFemaleen_US
dc.subject.meshHelicobacter Infections - Drug Therapy - Ethnologyen_US
dc.subject.meshHelicobacter Pylorien_US
dc.subject.meshHumansen_US
dc.subject.meshMaleen_US
dc.subject.meshMetronidazole - Therapeutic Useen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshOmeprazole - Therapeutic Useen_US
dc.subject.meshPatient Complianceen_US
dc.subject.meshTreatment Outcomeen_US
dc.titleStandard treatment for Helicobacter pylori infection is suboptimal in non-ulcer dyspepsia compared with duodenal ulcer in Chineseen_US
dc.typeArticleen_US
dc.identifier.emailWong, BCY:bcywong@hku.hken_US
dc.identifier.authorityWong, BCY=rp00429en_US
dc.description.naturelink_to_OA_fulltexten_US
dc.identifier.doi10.1111/j.1365-2036.2004.02283.xen_US
dc.identifier.pmid15644048en_US
dc.identifier.scopuseid_2-s2.0-20244380121en_US
dc.identifier.hkuros97002-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-20244380121&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume21en_US
dc.identifier.issue1en_US
dc.identifier.spage73en_US
dc.identifier.epage81en_US
dc.identifier.isiWOS:000226333900010-
dc.publisher.placeUnited Kingdomen_US
dc.identifier.scopusauthoridWong, WM=7403972413en_US
dc.identifier.scopusauthoridXiao, SD=12780231400en_US
dc.identifier.scopusauthoridHu, PJ=7201989582en_US
dc.identifier.scopusauthoridWang, WH=23390847100en_US
dc.identifier.scopusauthoridGu, Q=24469982400en_US
dc.identifier.scopusauthoridHuang, JQ=7403635051en_US
dc.identifier.scopusauthoridXia, HHX=8757161400en_US
dc.identifier.scopusauthoridWu, SM=15764046700en_US
dc.identifier.scopusauthoridLi, CJ=36078361000en_US
dc.identifier.scopusauthoridChen, MH=8642044500en_US
dc.identifier.scopusauthoridCui, Y=35200410400en_US
dc.identifier.scopusauthoridLai, KC=7402135595en_US
dc.identifier.scopusauthoridHu, WHC=25932937100en_US
dc.identifier.scopusauthoridChan, CK=7404813824en_US
dc.identifier.scopusauthoridLam, SK=7402279473en_US
dc.identifier.scopusauthoridWong, BCY=7402023340en_US
dc.identifier.citeulike74115-
dc.identifier.issnl0269-2813-

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats