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Article: Expression of peroxisome proliferator-activated receptor δ in human gastric cancer and its response to specific COX-2 inhibitor

TitleExpression of peroxisome proliferator-activated receptor δ in human gastric cancer and its response to specific COX-2 inhibitor
Authors
Issue Date2005
PublisherElsevier Ireland Ltd. The Journal's web site is located at http://www.elsevier.com/locate/canlet
Citation
Cancer Letters, 2005, v. 223 n. 1, p. 11-17 How to Cite?
AbstractPeroxisome proliferator-activated receptor δ (PPARδ) is ligand-activated transcription factor of the nuclear receptor superfamily which is recently implicated in carcinogenesis. We examined the expression profiles of PPARδ in human gastric cancer, normal gastric mucosa and gastric cancer cell lines by RT-PCR, Western blot and immunohistochemistry. PPARδ mRNA and protein was found to be ubiquitously expressed in all 5 gastric cancer cell lines, 40 gastric cancer samples and 10 normal gastric mucosa from non-cancer patients. Positive immunoreactivity was detected in the nuclei of normal and malignant gastric epithelium. Treatment of gastric cell line MKN45 that overexpressed cyclooxygenase-2 (COX-2) with specific COX-2 inhibitor NS398 resulted in a time- and dose-dependent suppression of PPARδ expression. In contrast, there was no suppression of PPARδ in MKN28 gastric cell line with low COX-2 expression. Our results demonstrated the ubiquitous expression of PPARδ in normal and cancer gastric epithelium. Suppression of PPARδ may be one of the mechanisms underlying the chemopreventive effects of COX-2 inhibitor. © 2004 Elsevier Ireland Ltd. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/162840
ISSN
2015 Impact Factor: 5.992
2015 SCImago Journal Rankings: 2.331
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorYu, Jen_US
dc.contributor.authorLeung, WKen_US
dc.contributor.authorChen, Jen_US
dc.contributor.authorEbert, MPAen_US
dc.contributor.authorMalfertheiner, Pen_US
dc.contributor.authorSung, JJYen_US
dc.date.accessioned2012-09-05T05:24:13Z-
dc.date.available2012-09-05T05:24:13Z-
dc.date.issued2005en_US
dc.identifier.citationCancer Letters, 2005, v. 223 n. 1, p. 11-17en_US
dc.identifier.issn0304-3835en_US
dc.identifier.urihttp://hdl.handle.net/10722/162840-
dc.description.abstractPeroxisome proliferator-activated receptor δ (PPARδ) is ligand-activated transcription factor of the nuclear receptor superfamily which is recently implicated in carcinogenesis. We examined the expression profiles of PPARδ in human gastric cancer, normal gastric mucosa and gastric cancer cell lines by RT-PCR, Western blot and immunohistochemistry. PPARδ mRNA and protein was found to be ubiquitously expressed in all 5 gastric cancer cell lines, 40 gastric cancer samples and 10 normal gastric mucosa from non-cancer patients. Positive immunoreactivity was detected in the nuclei of normal and malignant gastric epithelium. Treatment of gastric cell line MKN45 that overexpressed cyclooxygenase-2 (COX-2) with specific COX-2 inhibitor NS398 resulted in a time- and dose-dependent suppression of PPARδ expression. In contrast, there was no suppression of PPARδ in MKN28 gastric cell line with low COX-2 expression. Our results demonstrated the ubiquitous expression of PPARδ in normal and cancer gastric epithelium. Suppression of PPARδ may be one of the mechanisms underlying the chemopreventive effects of COX-2 inhibitor. © 2004 Elsevier Ireland Ltd. All rights reserved.en_US
dc.languageengen_US
dc.publisherElsevier Ireland Ltd. The Journal's web site is located at http://www.elsevier.com/locate/canleten_US
dc.relation.ispartofCancer Lettersen_US
dc.subject.meshAdulten_US
dc.subject.meshAgeden_US
dc.subject.meshCell Line, Tumoren_US
dc.subject.meshCyclooxygenase Inhibitors - Pharmacologyen_US
dc.subject.meshFemaleen_US
dc.subject.meshHumansen_US
dc.subject.meshMaleen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshPpar Gamma - Analysis - Antagonists & Inhibitors - Geneticsen_US
dc.subject.meshStomach Neoplasms - Chemistry - Metabolismen_US
dc.titleExpression of peroxisome proliferator-activated receptor δ in human gastric cancer and its response to specific COX-2 inhibitoren_US
dc.typeArticleen_US
dc.identifier.emailLeung, WK:waikleung@hku.hken_US
dc.identifier.authorityLeung, WK=rp01479en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1016/j.canlet.2004.09.052en_US
dc.identifier.pmid15890232-
dc.identifier.scopuseid_2-s2.0-18844439118en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-18844439118&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume223en_US
dc.identifier.issue1en_US
dc.identifier.spage11en_US
dc.identifier.epage17en_US
dc.identifier.isiWOS:000229553100002-
dc.publisher.placeIrelanden_US
dc.identifier.scopusauthoridYu, J=35351306800en_US
dc.identifier.scopusauthoridLeung, WK=7201504523en_US
dc.identifier.scopusauthoridChen, J=8347136200en_US
dc.identifier.scopusauthoridEbert, MPA=35239660600en_US
dc.identifier.scopusauthoridMalfertheiner, P=36048150200en_US
dc.identifier.scopusauthoridSung, JJY=35405352400en_US

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