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Article: Computed tomographic evaluation of the role of craniofacial and upper airway morphology in obstructive sleep apnea in Chinese

TitleComputed tomographic evaluation of the role of craniofacial and upper airway morphology in obstructive sleep apnea in Chinese
Authors
Issue Date2004
PublisherElsevier Ltd. The Journal's web site is located at http://www.elsevier.com/locate/rmed
Citation
Respiratory Medicine, 2004, v. 98 n. 4, p. 301-307 How to Cite?
AbstractObjectives: To evaluate the relationship between cephalometric parameters, upper airway morphological factors and obstructive sleep apnea (OSA) in Chinese subjects. Design: Polysomnogram (PSG) were performed and scored using standard criteria. Supine lateral cephalometric parameters and pharyngeal cross-sectional areas at the level of velopharynx (VA) and hypopharynx (HA) were measured from computed tomographic scans. The roles of these parameters and other anthropometric/demographic characteristics in OSA (apnea hypopnea index, AHI≥5) and their relationship with severity of OSA were explored by multiple logistic and multi-nominal regression analysis. Results: Ninety-two subjects, ranging from normal (n = 36), mild/moderate OSA (n = 34) to severe OSA (n = 22), were evaluated. Compared with normal subjects, OSA subjects were heavier (body mass index 27 vs. 24kg/m2 ) and older (47 vs. 42 years of age); had smaller VA size and VA to HA ratio, lower positioned hyoid bone, longer and thicker soft palate, and more retropositioned mandible relative to maxilia. After controlling for body mass index and age, subjects with severe OSA (AHI>30) had more retropositioned mandible relative to maxilla (odds ratio, OR 1.31, P = 0.044) and longer soft palate (OR 1.16, P = 0.01), while those with mild/moderate OSA had larger VA to HA ratio (OR 0.17, P = 0.018). Conclusions: Craniofacial factors and upper airway morphology contributed to severity of OSA in Chinese subjects. Having controlled for obesity, more retropositioned mandible was associated with more severe OSA. © 2003 Elsevier Ltd. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/162829
ISSN
2015 Impact Factor: 3.036
2015 SCImago Journal Rankings: 1.396
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorLam, Ben_US
dc.contributor.authorOoi, CGCen_US
dc.contributor.authorPeh, WCGen_US
dc.contributor.authorLauder, Ien_US
dc.contributor.authorTsang, KWTen_US
dc.contributor.authorLam, WKen_US
dc.contributor.authorIp, MSMen_US
dc.date.accessioned2012-09-05T05:24:03Z-
dc.date.available2012-09-05T05:24:03Z-
dc.date.issued2004en_US
dc.identifier.citationRespiratory Medicine, 2004, v. 98 n. 4, p. 301-307en_US
dc.identifier.issn0954-6111en_US
dc.identifier.urihttp://hdl.handle.net/10722/162829-
dc.description.abstractObjectives: To evaluate the relationship between cephalometric parameters, upper airway morphological factors and obstructive sleep apnea (OSA) in Chinese subjects. Design: Polysomnogram (PSG) were performed and scored using standard criteria. Supine lateral cephalometric parameters and pharyngeal cross-sectional areas at the level of velopharynx (VA) and hypopharynx (HA) were measured from computed tomographic scans. The roles of these parameters and other anthropometric/demographic characteristics in OSA (apnea hypopnea index, AHI≥5) and their relationship with severity of OSA were explored by multiple logistic and multi-nominal regression analysis. Results: Ninety-two subjects, ranging from normal (n = 36), mild/moderate OSA (n = 34) to severe OSA (n = 22), were evaluated. Compared with normal subjects, OSA subjects were heavier (body mass index 27 vs. 24kg/m2 ) and older (47 vs. 42 years of age); had smaller VA size and VA to HA ratio, lower positioned hyoid bone, longer and thicker soft palate, and more retropositioned mandible relative to maxilia. After controlling for body mass index and age, subjects with severe OSA (AHI>30) had more retropositioned mandible relative to maxilla (odds ratio, OR 1.31, P = 0.044) and longer soft palate (OR 1.16, P = 0.01), while those with mild/moderate OSA had larger VA to HA ratio (OR 0.17, P = 0.018). Conclusions: Craniofacial factors and upper airway morphology contributed to severity of OSA in Chinese subjects. Having controlled for obesity, more retropositioned mandible was associated with more severe OSA. © 2003 Elsevier Ltd. All rights reserved.en_US
dc.languageengen_US
dc.publisherElsevier Ltd. The Journal's web site is located at http://www.elsevier.com/locate/rmeden_US
dc.relation.ispartofRespiratory Medicineen_US
dc.subject.meshCephalometryen_US
dc.subject.meshChina - Ethnologyen_US
dc.subject.meshFemaleen_US
dc.subject.meshHumansen_US
dc.subject.meshMaleen_US
dc.subject.meshMandibleen_US
dc.subject.meshPharyngeal Diseases - Ethnology - Pathology - Radiographyen_US
dc.subject.meshPharynx - Pathologyen_US
dc.subject.meshPolysomnographyen_US
dc.subject.meshRegression Analysisen_US
dc.subject.meshSleep Apnea, Obstructive - Ethnology - Pathology - Radiographyen_US
dc.subject.meshTomography, X-Ray Computeden_US
dc.titleComputed tomographic evaluation of the role of craniofacial and upper airway morphology in obstructive sleep apnea in Chineseen_US
dc.typeArticleen_US
dc.identifier.emailIp, MSM:msmip@hku.hken_US
dc.identifier.authorityIp, MSM=rp00347en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1016/j.rmed.2003.10.009en_US
dc.identifier.pmid15072170-
dc.identifier.scopuseid_2-s2.0-1842475952en_US
dc.identifier.hkuros86227-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-1842475952&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume98en_US
dc.identifier.issue4en_US
dc.identifier.spage301en_US
dc.identifier.epage307en_US
dc.identifier.isiWOS:000220633100005-
dc.publisher.placeUnited Kingdomen_US
dc.identifier.scopusauthoridLam, B=9246012800en_US
dc.identifier.scopusauthoridOoi, CGC=7007084909en_US
dc.identifier.scopusauthoridPeh, WCG=7101824984en_US
dc.identifier.scopusauthoridLauder, I=35564928000en_US
dc.identifier.scopusauthoridTsang, KWT=7201555024en_US
dc.identifier.scopusauthoridLam, WK=7203021937en_US
dc.identifier.scopusauthoridIp, MSM=7102423259en_US

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