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Article: Left ventricular systolic asynchrony after acute myocardial infarction in patients with narrow QRS complexes

TitleLeft ventricular systolic asynchrony after acute myocardial infarction in patients with narrow QRS complexes
Authors
Issue Date2005
PublisherMosby, Inc. The Journal's web site is located at http://www.elsevier.com/locate/ahj
Citation
American Heart Journal, 2005, v. 149 n. 3, p. 497-503 How to Cite?
AbstractBackground: The aim of the study was to assess the degree of left ventricular (LV) asynchrony after myocardial infarction (MI) in patients with a narrow QRS complex using tissue Doppler imaging (TDI) and correlate this with the site and extent of the infarction measured by contrast-enhanced magnetic resonance imaging (Ce-MRI). Methods: Echocardiography with TDI and Ce-MRI was performed within 6 days of acute MI in 47 patients and compared with 69 age-matched healthy volunteers. Regional myocardial velocities were assessed in 12 segments, and the corresponding systolic velocity (Sm), early diastolic velocity (Em), as well as the time to peak Sm (Ts) and time to peak Em (Te) were measured. To assess LV synchronicity, SDs of Ts (Ts-SD) and Te (Te-SD) of all 12 segments were computed. Location and size of infarct were confirmed by Ce-MRI with a 16-segment model. Results: All the patients had a normal QRS complex duration. The Ts-SD was significantly prolonged in the MI group when compared with controls (42.2 ± 13.7 vs 18.0 ± 7.0 milliseconds, P <. 001). The Ts-SD was longer in patients with anterior than inferior MI (46.8 ± 13.9 vs 34.6 ± 8.5 milliseconds, P =. 002). Stepwise multiple regression analysis revealed that infarct size was the main independent predictor of systolic asynchrony (B = 0.79, 95% CI 0.75-1.23, P <. 001). Asynchrony was not related to the transmurality of the infarction. Conclusions: Myocardial infarction has a significant impact on LV synchronicity even in those with a narrow QRS complex. The degree of LV systolic asynchrony is mainly determined by the infarct size and not transmurality. © 2005, Elsevier Inc. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/162827
ISSN
2015 Impact Factor: 4.332
2015 SCImago Journal Rankings: 3.157
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorZhang, Yen_US
dc.contributor.authorChan, AKYen_US
dc.contributor.authorYu, CMen_US
dc.contributor.authorLam, WWMen_US
dc.contributor.authorYip, GWKen_US
dc.contributor.authorFung, WHen_US
dc.contributor.authorSo, NMCen_US
dc.contributor.authorWang, Men_US
dc.contributor.authorSanderson, JEen_US
dc.date.accessioned2012-09-05T05:24:01Z-
dc.date.available2012-09-05T05:24:01Z-
dc.date.issued2005en_US
dc.identifier.citationAmerican Heart Journal, 2005, v. 149 n. 3, p. 497-503en_US
dc.identifier.issn0002-8703en_US
dc.identifier.urihttp://hdl.handle.net/10722/162827-
dc.description.abstractBackground: The aim of the study was to assess the degree of left ventricular (LV) asynchrony after myocardial infarction (MI) in patients with a narrow QRS complex using tissue Doppler imaging (TDI) and correlate this with the site and extent of the infarction measured by contrast-enhanced magnetic resonance imaging (Ce-MRI). Methods: Echocardiography with TDI and Ce-MRI was performed within 6 days of acute MI in 47 patients and compared with 69 age-matched healthy volunteers. Regional myocardial velocities were assessed in 12 segments, and the corresponding systolic velocity (Sm), early diastolic velocity (Em), as well as the time to peak Sm (Ts) and time to peak Em (Te) were measured. To assess LV synchronicity, SDs of Ts (Ts-SD) and Te (Te-SD) of all 12 segments were computed. Location and size of infarct were confirmed by Ce-MRI with a 16-segment model. Results: All the patients had a normal QRS complex duration. The Ts-SD was significantly prolonged in the MI group when compared with controls (42.2 ± 13.7 vs 18.0 ± 7.0 milliseconds, P <. 001). The Ts-SD was longer in patients with anterior than inferior MI (46.8 ± 13.9 vs 34.6 ± 8.5 milliseconds, P =. 002). Stepwise multiple regression analysis revealed that infarct size was the main independent predictor of systolic asynchrony (B = 0.79, 95% CI 0.75-1.23, P <. 001). Asynchrony was not related to the transmurality of the infarction. Conclusions: Myocardial infarction has a significant impact on LV synchronicity even in those with a narrow QRS complex. The degree of LV systolic asynchrony is mainly determined by the infarct size and not transmurality. © 2005, Elsevier Inc. All rights reserved.en_US
dc.languageengen_US
dc.publisherMosby, Inc. The Journal's web site is located at http://www.elsevier.com/locate/ahjen_US
dc.relation.ispartofAmerican Heart Journalen_US
dc.subject.meshContrast Media - Analysisen_US
dc.subject.meshEchocardiographyen_US
dc.subject.meshElectrocardiographyen_US
dc.subject.meshFemaleen_US
dc.subject.meshHumansen_US
dc.subject.meshImage Enhancement - Methodsen_US
dc.subject.meshMagnetic Resonance Imagingen_US
dc.subject.meshMaleen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshMyocardial Infarction - Diagnosis - Physiopathologyen_US
dc.subject.meshObserver Variationen_US
dc.subject.meshRegression Analysisen_US
dc.subject.meshVentricular Dysfunction, Left - Diagnosis - Physiopathologyen_US
dc.titleLeft ventricular systolic asynchrony after acute myocardial infarction in patients with narrow QRS complexesen_US
dc.typeArticleen_US
dc.identifier.emailWang, M:meiwang@hkucc.hku.hken_US
dc.identifier.authorityWang, M=rp00281en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1016/j.ahj.2004.05.054en_US
dc.identifier.pmid15864239-
dc.identifier.scopuseid_2-s2.0-17844387827en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-17844387827&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume149en_US
dc.identifier.issue3en_US
dc.identifier.spage497en_US
dc.identifier.epage503en_US
dc.identifier.isiWOS:000228487800019-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridZhang, Y=7601312580en_US
dc.identifier.scopusauthoridChan, AKY=7403168116en_US
dc.identifier.scopusauthoridYu, CM=7404976646en_US
dc.identifier.scopusauthoridLam, WWM=13410486800en_US
dc.identifier.scopusauthoridYip, GWK=7006525328en_US
dc.identifier.scopusauthoridFung, WH=7102150336en_US
dc.identifier.scopusauthoridSo, NMC=7003780596en_US
dc.identifier.scopusauthoridWang, M=7406690398en_US
dc.identifier.scopusauthoridSanderson, JE=7202371250en_US

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