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Article: Somatic β-catenin mutation in gastric carcinoma - An infrequent event that is not specific for microsatellite instability

TitleSomatic β-catenin mutation in gastric carcinoma - An infrequent event that is not specific for microsatellite instability
Authors
Issue Date2001
PublisherElsevier Ireland Ltd. The Journal's web site is located at http://www.elsevier.com/locate/canlet
Citation
Cancer Letters, 2001, v. 163 n. 1, p. 125-130 How to Cite?
AbstractWe screened 90 cases of gastric carcinoma (GCA) samples for β-catenin exon 3 mutation and assessed its possible relationship with microsatellite instability (MSI). Three mutations were detected in two samples, including a single mutation in an intestinal type and double mutations in a diffuse type GCA. One of the mutations found in the diffuse type GCA sample was a non-sense mutation at codon 68 (CAG→ TAG). This novel mutation was predicted to disrupt the binding of β-catenin to α-catenin and may be related to the diffuse type morphology. The other two mutations were missense mutations involved or related to the GSK-3β phosphorylation site, which have been reported previously. No MSI can be demonstrated in the two cases with β-catenin mutation. Our results suggested that β-catenin mutation was infrequent in GCA and appeared not specific for MSI. © 2001 Elsevier Science Ireland Ltd.
Persistent Identifierhttp://hdl.handle.net/10722/162825
ISSN
2015 Impact Factor: 5.992
2015 SCImago Journal Rankings: 2.331
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorTong, JHMen_US
dc.contributor.authorTo, KFen_US
dc.contributor.authorNg, EKWen_US
dc.contributor.authorLau, JYWen_US
dc.contributor.authorLee, TLen_US
dc.contributor.authorLo, KWen_US
dc.contributor.authorLeung, WKen_US
dc.contributor.authorTang, NLSen_US
dc.contributor.authorChan, FKLen_US
dc.contributor.authorSung, JJYen_US
dc.contributor.authorChung, SCSen_US
dc.date.accessioned2012-09-05T05:23:58Z-
dc.date.available2012-09-05T05:23:58Z-
dc.date.issued2001en_US
dc.identifier.citationCancer Letters, 2001, v. 163 n. 1, p. 125-130en_US
dc.identifier.issn0304-3835en_US
dc.identifier.urihttp://hdl.handle.net/10722/162825-
dc.description.abstractWe screened 90 cases of gastric carcinoma (GCA) samples for β-catenin exon 3 mutation and assessed its possible relationship with microsatellite instability (MSI). Three mutations were detected in two samples, including a single mutation in an intestinal type and double mutations in a diffuse type GCA. One of the mutations found in the diffuse type GCA sample was a non-sense mutation at codon 68 (CAG→ TAG). This novel mutation was predicted to disrupt the binding of β-catenin to α-catenin and may be related to the diffuse type morphology. The other two mutations were missense mutations involved or related to the GSK-3β phosphorylation site, which have been reported previously. No MSI can be demonstrated in the two cases with β-catenin mutation. Our results suggested that β-catenin mutation was infrequent in GCA and appeared not specific for MSI. © 2001 Elsevier Science Ireland Ltd.en_US
dc.languageengen_US
dc.publisherElsevier Ireland Ltd. The Journal's web site is located at http://www.elsevier.com/locate/canleten_US
dc.relation.ispartofCancer Lettersen_US
dc.subject.meshAdulten_US
dc.subject.meshAgeden_US
dc.subject.meshAged, 80 And Overen_US
dc.subject.meshAmino Acid Substitutionen_US
dc.subject.meshBase Sequenceen_US
dc.subject.meshCytoskeletal Proteins - Genetics - Metabolismen_US
dc.subject.meshDna - Chemistry - Geneticsen_US
dc.subject.meshDna Mutational Analysisen_US
dc.subject.meshFemaleen_US
dc.subject.meshHumansen_US
dc.subject.meshImmunohistochemistryen_US
dc.subject.meshMaleen_US
dc.subject.meshMicrosatellite Repeats - Geneticsen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshMutationen_US
dc.subject.meshPoint Mutationen_US
dc.subject.meshStomach Neoplasms - Genetics - Metabolism - Pathologyen_US
dc.subject.meshTrans-Activatorsen_US
dc.subject.meshBeta Cateninen_US
dc.titleSomatic β-catenin mutation in gastric carcinoma - An infrequent event that is not specific for microsatellite instabilityen_US
dc.typeArticleen_US
dc.identifier.emailLeung, WK:waikleung@hku.hken_US
dc.identifier.authorityLeung, WK=rp01479en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1016/S0304-3835(00)00681-9en_US
dc.identifier.pmid11163116-
dc.identifier.scopuseid_2-s2.0-17644438010en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-17644438010&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume163en_US
dc.identifier.issue1en_US
dc.identifier.spage125en_US
dc.identifier.epage130en_US
dc.identifier.isiWOS:000168440500016-
dc.publisher.placeIrelanden_US
dc.identifier.scopusauthoridTong, JHM=7202724564en_US
dc.identifier.scopusauthoridTo, KF=24336843300en_US
dc.identifier.scopusauthoridNg, EKW=7201647539en_US
dc.identifier.scopusauthoridLau, JYW=13907867100en_US
dc.identifier.scopusauthoridLee, TL=35292432600en_US
dc.identifier.scopusauthoridLo, KW=24302880900en_US
dc.identifier.scopusauthoridLeung, WK=7201504523en_US
dc.identifier.scopusauthoridTang, NLS=7202344588en_US
dc.identifier.scopusauthoridChan, FKL=7202586434en_US
dc.identifier.scopusauthoridSung, JJY=35405352400en_US
dc.identifier.scopusauthoridChung, SCS=19642462800en_US

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