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Article: Differential north to south gastric cancer-duodenal ulcer gradient in China

TitleDifferential north to south gastric cancer-duodenal ulcer gradient in China
Authors
Issue Date1998
PublisherWiley-Blackwell Publishing Asia. The Journal's web site is located at http://www.blackwellpublishing.com/journals/JGH
Citation
Journal Of Gastroenterology And Hepatology, 1998, v. 13 n. 10, p. 1050-1057 How to Cite?
AbstractThere are suggestions that duodenal ulcer protects individuals from gastric cancer and that rice is ulcerogenic while wheat is gastro- protective. We aimed to examine the relationship of gastric cancer, duodenal and gastric ulcers in different geographical regions in China and identified dietary risk factors for duodenal ulcer and gastric cancer. The prevalence of peptic ulcer and gastric cancer among symptomatic patients in eight major cities, four each from the north and the south representing all the six defined regions of China were studied. Endoscopy and case records over a 10 year period were reviewed and cases of confirmed duodenal and gastric ulcer and gastric cancer, together with the total number of endoscopies performed per year, were recorded. Rates were expressed as cases/1000 endoscopies. Results were compared to another epidemiological study on diet and mortality in the same regions in China conducted at the same time. Duodenal ulcer rates were 2.4-fold higher in southern China than northern China, whereas gastric cancer rates were 1.6-fold higher in the north than in the south. Correlation studies showed for the first time an inverse linear relationship between the gastric cancer rates and the duodenal ulcer rates (r = -0.8076, P = 0.015), as well as the duodenal ulcer: gastric ulcer ratios (r = -0.9133, P = 0.002). Gastric ulcer rates were higher in southern China but did not correlate with the gastric cancer rates (r = 0.1455, P = 0.731). Duodenal ulcer rates were found to be related to daily rice intake (r= 0.8554, P= 0.029) and inversely related to daily wheat flour intake (r = -0.8472, P = 0.033). Gastric cancer rates were not related to any dietary risk factors tested. We concluded there was an inverse relationship between gastric cancer rates and duodenal ulcer rates. Although duodenal ulceration and gastric cancer are both linked to Helicobacter pylori infection, the findings of this study indicate independent additional aetiological factors for the pathogenesis of these conditions. Dietary factors such as rice or wheat intake may play a role.
Persistent Identifierhttp://hdl.handle.net/10722/162801
ISSN
2015 Impact Factor: 3.322
2015 SCImago Journal Rankings: 1.190
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorWong, BCYen_US
dc.contributor.authorChing, CKen_US
dc.contributor.authorLam, SKen_US
dc.contributor.authorLi, ZLen_US
dc.contributor.authorChen, BWen_US
dc.contributor.authorLi, YNen_US
dc.contributor.authorLiu, HJen_US
dc.contributor.authorLiu, JBen_US
dc.contributor.authorWang, BEen_US
dc.contributor.authorYuan, SZen_US
dc.contributor.authorXu, CPen_US
dc.contributor.authorHou, XHen_US
dc.contributor.authorZhang, ATen_US
dc.contributor.authorZheng, ZTen_US
dc.date.accessioned2012-09-05T05:23:42Z-
dc.date.available2012-09-05T05:23:42Z-
dc.date.issued1998en_US
dc.identifier.citationJournal Of Gastroenterology And Hepatology, 1998, v. 13 n. 10, p. 1050-1057en_US
dc.identifier.issn0815-9319en_US
dc.identifier.urihttp://hdl.handle.net/10722/162801-
dc.description.abstractThere are suggestions that duodenal ulcer protects individuals from gastric cancer and that rice is ulcerogenic while wheat is gastro- protective. We aimed to examine the relationship of gastric cancer, duodenal and gastric ulcers in different geographical regions in China and identified dietary risk factors for duodenal ulcer and gastric cancer. The prevalence of peptic ulcer and gastric cancer among symptomatic patients in eight major cities, four each from the north and the south representing all the six defined regions of China were studied. Endoscopy and case records over a 10 year period were reviewed and cases of confirmed duodenal and gastric ulcer and gastric cancer, together with the total number of endoscopies performed per year, were recorded. Rates were expressed as cases/1000 endoscopies. Results were compared to another epidemiological study on diet and mortality in the same regions in China conducted at the same time. Duodenal ulcer rates were 2.4-fold higher in southern China than northern China, whereas gastric cancer rates were 1.6-fold higher in the north than in the south. Correlation studies showed for the first time an inverse linear relationship between the gastric cancer rates and the duodenal ulcer rates (r = -0.8076, P = 0.015), as well as the duodenal ulcer: gastric ulcer ratios (r = -0.9133, P = 0.002). Gastric ulcer rates were higher in southern China but did not correlate with the gastric cancer rates (r = 0.1455, P = 0.731). Duodenal ulcer rates were found to be related to daily rice intake (r= 0.8554, P= 0.029) and inversely related to daily wheat flour intake (r = -0.8472, P = 0.033). Gastric cancer rates were not related to any dietary risk factors tested. We concluded there was an inverse relationship between gastric cancer rates and duodenal ulcer rates. Although duodenal ulceration and gastric cancer are both linked to Helicobacter pylori infection, the findings of this study indicate independent additional aetiological factors for the pathogenesis of these conditions. Dietary factors such as rice or wheat intake may play a role.en_US
dc.languageengen_US
dc.publisherWiley-Blackwell Publishing Asia. The Journal's web site is located at http://www.blackwellpublishing.com/journals/JGHen_US
dc.relation.ispartofJournal of Gastroenterology and Hepatologyen_US
dc.subject.meshAdulten_US
dc.subject.meshChina - Epidemiologyen_US
dc.subject.meshDieten_US
dc.subject.meshDiet Surveysen_US
dc.subject.meshDuodenal Ulcer - Epidemiology - Etiologyen_US
dc.subject.meshFemaleen_US
dc.subject.meshHelicobacter Infections - Epidemiologyen_US
dc.subject.meshHelicobacter Pylorien_US
dc.subject.meshHumansen_US
dc.subject.meshMaleen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshOryza Sativaen_US
dc.subject.meshPrevalenceen_US
dc.subject.meshRetrospective Studiesen_US
dc.subject.meshRisk Factorsen_US
dc.subject.meshStomach Neoplasms - Epidemiology - Etiologyen_US
dc.subject.meshStomach Ulcer - Epidemiology - Etiologyen_US
dc.subject.meshTriticumen_US
dc.titleDifferential north to south gastric cancer-duodenal ulcer gradient in Chinaen_US
dc.typeArticleen_US
dc.identifier.emailWong, BCY:bcywong@hku.hken_US
dc.identifier.authorityWong, BCY=rp00429en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1111/j.1440-1746.1998.tb00569.x-
dc.identifier.pmid9835323-
dc.identifier.scopuseid_2-s2.0-15644367910en_US
dc.identifier.hkuros46448-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-15644367910&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume13en_US
dc.identifier.issue10en_US
dc.identifier.spage1050en_US
dc.identifier.epage1057en_US
dc.identifier.isiWOS:000076893900014-
dc.publisher.placeAustraliaen_US
dc.identifier.scopusauthoridWong, BCY=7402023340en_US
dc.identifier.scopusauthoridChing, CK=7102130825en_US
dc.identifier.scopusauthoridLam, SK=7402279473en_US
dc.identifier.scopusauthoridLi, ZL=19335004900en_US
dc.identifier.scopusauthoridChen, BW=7408610379en_US
dc.identifier.scopusauthoridLi, YN=36012284100en_US
dc.identifier.scopusauthoridLiu, HJ=20635103000en_US
dc.identifier.scopusauthoridLiu, JB=36065778800en_US
dc.identifier.scopusauthoridWang, BE=7405917909en_US
dc.identifier.scopusauthoridYuan, SZ=7403272894en_US
dc.identifier.scopusauthoridXu, CP=7404182062en_US
dc.identifier.scopusauthoridHou, XH=7402838898en_US
dc.identifier.scopusauthoridZhang, AT=20636479600en_US
dc.identifier.scopusauthoridZheng, ZT=7403007419en_US

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