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Article: Dialysate cell population and cancer antigen 125 in stable continuous ambulatory peritoneal dialysis patients: Their relationship with transport parameters

TitleDialysate cell population and cancer antigen 125 in stable continuous ambulatory peritoneal dialysis patients: Their relationship with transport parameters
Authors
Keywordscancer antigen 125
Continuous ambulatory peritoneal dialysis
macrophages
mesothelial cells
peritoneal transport
peritonitis
Issue Date1997
PublisherWB Saunders Co. The Journal's web site is located at http://www.elsevier.com/locate/ajkd
Citation
American Journal Of Kidney Diseases, 1997, v. 29 n. 5, p. 699-705 How to Cite?
AbstractWe investigated the total cell count and cell population of the overnight peritoneal dialysis effluent (PDE) by flow cytometry in 76 stable continuous ambulatory peritoneal dialysis (CAPD) patients. The mean percentage of mesothelial cells and macrophages was 4.4% and 57%, respectively. A higher percentage of dead cells among the mesothelial cells compared with other cell populations in the PDE was observed. Peritoneal transport properties were studied in every patient by determining the dialysate to plasma ratio of creatinine concentration (D/P) at the fourth hour of the peritoneal equilibration test, and the mass transfer area coefficient of creatinine (MTACCr) or glucose. Cancer antigen 125 (CA125), suggested as a bulk marker for the mesothelial mass in stable peritoneal dialysis patients, was determined in the PDE. No correlation was demonstrated between CA125 and the number of mesothelial cells, lymphocytes, or macrophages in the PDE. A significant correlation was observed between CA125 and different parameters of peritoneal transport (D/P and MTACCr). On the contrary, neither the history of peritonitis nor the duration of CAPD appeared to affect the CA125 concentration in the PDE. The lack of correlation between CA125 in the PDE and the duration of CAPD may be related to the early loss of peritoneal transport properties as a result of the use of hypertonic dialysate in the majority of our patients with small-volume CAPD (3 x 2 L daily exchange). Our findings suggest that CA125 may not necessarily correlate well with the number of mesothelial cells in PDE. In patients with vanishing of the mesothelial layer, the measurement of CA125 (as a bulk marker for the mesothelial mass in the peritoneum) may reflect the change of peritoneal transport properties.
Persistent Identifierhttp://hdl.handle.net/10722/162782
ISSN
2015 Impact Factor: 6.269
2015 SCImago Journal Rankings: 2.313
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorLai, KNen_HK
dc.contributor.authorLai, KBen_HK
dc.contributor.authorSzeto, CCen_HK
dc.contributor.authorHo, KKLen_HK
dc.contributor.authorPoon, Pen_HK
dc.contributor.authorLam, CWKen_HK
dc.contributor.authorLeung, JCK-
dc.date.accessioned2012-09-05T05:23:28Z-
dc.date.available2012-09-05T05:23:28Z-
dc.date.issued1997en_HK
dc.identifier.citationAmerican Journal Of Kidney Diseases, 1997, v. 29 n. 5, p. 699-705en_HK
dc.identifier.issn0272-6386en_HK
dc.identifier.urihttp://hdl.handle.net/10722/162782-
dc.description.abstractWe investigated the total cell count and cell population of the overnight peritoneal dialysis effluent (PDE) by flow cytometry in 76 stable continuous ambulatory peritoneal dialysis (CAPD) patients. The mean percentage of mesothelial cells and macrophages was 4.4% and 57%, respectively. A higher percentage of dead cells among the mesothelial cells compared with other cell populations in the PDE was observed. Peritoneal transport properties were studied in every patient by determining the dialysate to plasma ratio of creatinine concentration (D/P) at the fourth hour of the peritoneal equilibration test, and the mass transfer area coefficient of creatinine (MTACCr) or glucose. Cancer antigen 125 (CA125), suggested as a bulk marker for the mesothelial mass in stable peritoneal dialysis patients, was determined in the PDE. No correlation was demonstrated between CA125 and the number of mesothelial cells, lymphocytes, or macrophages in the PDE. A significant correlation was observed between CA125 and different parameters of peritoneal transport (D/P and MTACCr). On the contrary, neither the history of peritonitis nor the duration of CAPD appeared to affect the CA125 concentration in the PDE. The lack of correlation between CA125 in the PDE and the duration of CAPD may be related to the early loss of peritoneal transport properties as a result of the use of hypertonic dialysate in the majority of our patients with small-volume CAPD (3 x 2 L daily exchange). Our findings suggest that CA125 may not necessarily correlate well with the number of mesothelial cells in PDE. In patients with vanishing of the mesothelial layer, the measurement of CA125 (as a bulk marker for the mesothelial mass in the peritoneum) may reflect the change of peritoneal transport properties.en_HK
dc.languageengen_US
dc.publisherWB Saunders Co. The Journal's web site is located at http://www.elsevier.com/locate/ajkden_HK
dc.relation.ispartofAmerican Journal of Kidney Diseasesen_HK
dc.subjectcancer antigen 125en_HK
dc.subjectContinuous ambulatory peritoneal dialysisen_HK
dc.subjectmacrophagesen_HK
dc.subjectmesothelial cellsen_HK
dc.subjectperitoneal transporten_HK
dc.subjectperitonitisen_HK
dc.subject.meshAdulten_US
dc.subject.meshBiological Transporten_US
dc.subject.meshCa-125 Antigen - Analysisen_US
dc.subject.meshCell Counten_US
dc.subject.meshCells, Cultureden_US
dc.subject.meshCross-Sectional Studiesen_US
dc.subject.meshDialysis Solutions - Analysisen_US
dc.subject.meshEpithelial Cellsen_US
dc.subject.meshFemaleen_US
dc.subject.meshFlow Cytometryen_US
dc.subject.meshHumansen_US
dc.subject.meshMacrophages, Peritoneal - Cytologyen_US
dc.subject.meshMaleen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshPeritoneal Cavity - Cytologyen_US
dc.subject.meshPeritoneal Dialysis, Continuous Ambulatory - Statistics & Numerical Dataen_US
dc.subject.meshPeritoneum - Metabolismen_US
dc.titleDialysate cell population and cancer antigen 125 in stable continuous ambulatory peritoneal dialysis patients: Their relationship with transport parametersen_HK
dc.typeArticleen_HK
dc.identifier.emailLai, KN: knlai@hku.hken_HK
dc.identifier.emailLeung, JCK: jckleung@hku.hken_HK
dc.identifier.authorityLai, KN=rp00324en_HK
dc.identifier.authorityLeung, JCK=rp00448en_HK
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1016/S0272-6386(97)90122-0-
dc.identifier.pmid9159303-
dc.identifier.scopuseid_2-s2.0-12644277373en_HK
dc.identifier.hkuros41373-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-12644277373&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume29en_HK
dc.identifier.issue5en_HK
dc.identifier.spage699en_HK
dc.identifier.epage705en_HK
dc.identifier.isiWOS:A1997WZ64100008-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridLai, KN=7402135706en_HK
dc.identifier.scopusauthoridSzeto, CC=35495407200en_HK
dc.identifier.scopusauthoridHo, KKL=15850509100en_HK
dc.identifier.scopusauthoridPoon, P=9336837000en_HK
dc.identifier.scopusauthoridLam, CWK=8531362100en_HK
dc.identifier.scopusauthoridLeung, JCK=7202180349en_HK
dc.customcontrol.immutablejt 130530-

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