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Article: Tissue Doppler imaging provides incremental prognostic value in patients with systemic hypertension and left ventricular hypertrophy

TitleTissue Doppler imaging provides incremental prognostic value in patients with systemic hypertension and left ventricular hypertrophy
Authors
Issue Date2005
PublisherLippincott Williams & Wilkins, Ltd. The Journal's web site is located at http://www.jhypertension.com/
Citation
Journal Of Hypertension, 2005, v. 23 n. 1, p. 183-191 How to Cite?
AbstractObjectives: We sought to determine the prognostic value of left ventricular (LV) mitral annular velocities measured by tissue Doppler imaging (TDI) in hypertensive patients with echocardiographic evidence of LV hypertrophy. Background: Echo LV hypertrophy and LV geometry provide additional predictive value of all-cause mortality beyond traditional cardiovascular risk factors. Limited data exist regarding the predictive value of TDI velocities for cardiovascular risk stratification in treated hypertensive patients. Methods: Two-dimensional and Doppler echocardiograms were obtained in 252 consecutive subjects, including 174 subjects with systemic hypertension and 78 age-matched normal subjects. The end point was cardiac death in subsequent median follow-up of 19 months. Results Nineteen patients (7.54%) died of cardiac causes. The TDI mitral annulus systolic velocity and the early diastolic mitral annular velocity (Em) were significantly lower in the non-survivors (all P < 0.001). The pseudonormal (PN) or restrictive filling pattern (RFP) was associated with cardiac mortality. The other parameters associated with cardiac mortality were LV ejection fraction, LV mass index, inter-ventricular septal wall thickness in diastole and the ratio of early mitral inflow to early myocardial velocity. In multivariate analysis, Em, interventricular septal wall thickness in diastole and either PN or RFP were the strongest predictors. The addition of Em < 3.5 cm/s significantly improved the outcome of a model that contained clinical risk factors, inter-ventricular septal wall thickness in diastole > 1.4 cm and either PN or RFP (P = 0.043). Conclusions: Early diastolic mitral annulus velocity measured by TDI provides prognostic information, incremental to clinical data and standard echocardiographic variables, for risk stratification of hypertensive patients under treatment. © 2005 Lippincott Williams & Wilkins.
Persistent Identifierhttp://hdl.handle.net/10722/162778
ISSN
2015 Impact Factor: 5.062
2015 SCImago Journal Rankings: 2.193
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorWang, Men_US
dc.contributor.authorYip, GWKen_US
dc.contributor.authorWang, AYMen_US
dc.contributor.authorZhang, Yen_US
dc.contributor.authorPik, YHen_US
dc.contributor.authorMui, KTen_US
dc.contributor.authorYu, CMen_US
dc.contributor.authorSanderson, JEen_US
dc.date.accessioned2012-09-05T05:23:27Z-
dc.date.available2012-09-05T05:23:27Z-
dc.date.issued2005en_US
dc.identifier.citationJournal Of Hypertension, 2005, v. 23 n. 1, p. 183-191en_US
dc.identifier.issn0263-6352en_US
dc.identifier.urihttp://hdl.handle.net/10722/162778-
dc.description.abstractObjectives: We sought to determine the prognostic value of left ventricular (LV) mitral annular velocities measured by tissue Doppler imaging (TDI) in hypertensive patients with echocardiographic evidence of LV hypertrophy. Background: Echo LV hypertrophy and LV geometry provide additional predictive value of all-cause mortality beyond traditional cardiovascular risk factors. Limited data exist regarding the predictive value of TDI velocities for cardiovascular risk stratification in treated hypertensive patients. Methods: Two-dimensional and Doppler echocardiograms were obtained in 252 consecutive subjects, including 174 subjects with systemic hypertension and 78 age-matched normal subjects. The end point was cardiac death in subsequent median follow-up of 19 months. Results Nineteen patients (7.54%) died of cardiac causes. The TDI mitral annulus systolic velocity and the early diastolic mitral annular velocity (Em) were significantly lower in the non-survivors (all P < 0.001). The pseudonormal (PN) or restrictive filling pattern (RFP) was associated with cardiac mortality. The other parameters associated with cardiac mortality were LV ejection fraction, LV mass index, inter-ventricular septal wall thickness in diastole and the ratio of early mitral inflow to early myocardial velocity. In multivariate analysis, Em, interventricular septal wall thickness in diastole and either PN or RFP were the strongest predictors. The addition of Em < 3.5 cm/s significantly improved the outcome of a model that contained clinical risk factors, inter-ventricular septal wall thickness in diastole > 1.4 cm and either PN or RFP (P = 0.043). Conclusions: Early diastolic mitral annulus velocity measured by TDI provides prognostic information, incremental to clinical data and standard echocardiographic variables, for risk stratification of hypertensive patients under treatment. © 2005 Lippincott Williams & Wilkins.en_US
dc.languageengen_US
dc.publisherLippincott Williams & Wilkins, Ltd. The Journal's web site is located at http://www.jhypertension.com/en_US
dc.relation.ispartofJournal of Hypertensionen_US
dc.subject.meshAgeden_US
dc.subject.meshBlood Flow Velocityen_US
dc.subject.meshCohort Studiesen_US
dc.subject.meshDeathen_US
dc.subject.meshDiastoleen_US
dc.subject.meshEchocardiography, Doppleren_US
dc.subject.meshFemaleen_US
dc.subject.meshHumansen_US
dc.subject.meshHypertension - Mortality - Ultrasonographyen_US
dc.subject.meshHypertrophy, Left Ventricular - Mortality - Ultrasonographyen_US
dc.subject.meshMaleen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshMitral Valve - Physiologyen_US
dc.subject.meshPredictive Value Of Testsen_US
dc.subject.meshPrevalenceen_US
dc.subject.meshPrognosisen_US
dc.subject.meshSurvival Analysisen_US
dc.subject.meshVentricular Dysfunction, Left - Mortality - Ultrasonographyen_US
dc.titleTissue Doppler imaging provides incremental prognostic value in patients with systemic hypertension and left ventricular hypertrophyen_US
dc.typeArticleen_US
dc.identifier.emailWang, M:meiwang@hkucc.hku.hken_US
dc.identifier.authorityWang, M=rp00281en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1097/00004872-200501000-00029en_US
dc.identifier.pmid15643141-
dc.identifier.scopuseid_2-s2.0-12344300355en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-12344300355&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume23en_US
dc.identifier.issue1en_US
dc.identifier.spage183en_US
dc.identifier.epage191en_US
dc.identifier.isiWOS:000226497900029-
dc.publisher.placeUnited Kingdomen_US
dc.identifier.scopusauthoridWang, M=7406690398en_US
dc.identifier.scopusauthoridYip, GWK=7006525328en_US
dc.identifier.scopusauthoridWang, AYM=13606226000en_US
dc.identifier.scopusauthoridZhang, Y=7601312580en_US
dc.identifier.scopusauthoridPik, YH=16639471500en_US
dc.identifier.scopusauthoridMui, KT=16638565600en_US
dc.identifier.scopusauthoridYu, CM=7404976646en_US
dc.identifier.scopusauthoridSanderson, JE=7202371250en_US

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