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Article: Sexual transmission of hepatitis B infection despite the presence of hepatitis B virus immunity in recipients of allogeneic bone marrow transplantation

TitleSexual transmission of hepatitis B infection despite the presence of hepatitis B virus immunity in recipients of allogeneic bone marrow transplantation
Authors
Issue Date2005
PublisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/jcv
Citation
Journal Of Clinical Virology, 2005, v. 32 n. 2, p. 173-178 How to Cite?
AbstractAfter hematopoietic cell transplantation (HCT), hepatitis due to hepatitis B virus (HBV) rarely occurred beyond the initial 12 months after transplantation. We investigated the cause of "late" hepatitis due to HBV infection in two recipients after allogeneic HCT. Two male patients with acute myeloid leukemia and light chain myeloma, respectively, developed HBV-related hepatitis more than 2 years after HCT. All serum samples collected from the recipients, donors and their respective spouses were tested for HBV DNA by nested PCR, and if positive further quantified by Digene Hybrid Capture assay II. The HBV genotype was determined by PCR and sequencing. Genotypic analysis suggested that the cause of "late" hepatitis was due to acute HBV infection transmitted from their respective spouse. Our findings suggested that sexual precautions should be taken in these patients after HCT. Alternatively, or even additionally, active vaccination should be delivered to these patients once they have lost their HBV immunity. © 2004 Published by Elsevier B.V.
Persistent Identifierhttp://hdl.handle.net/10722/162773
ISSN
2015 Impact Factor: 2.647
2015 SCImago Journal Rankings: 1.503
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorHui, CKen_US
dc.contributor.authorYu, Jen_US
dc.contributor.authorAu, WYen_US
dc.contributor.authorZhang, HYen_US
dc.contributor.authorBartholomeusz, Aen_US
dc.contributor.authorLocarnini, Sen_US
dc.contributor.authorKwong, YLen_US
dc.contributor.authorLiang, Ren_US
dc.contributor.authorLau, GKKen_US
dc.date.accessioned2012-09-05T05:23:21Z-
dc.date.available2012-09-05T05:23:21Z-
dc.date.issued2005en_US
dc.identifier.citationJournal Of Clinical Virology, 2005, v. 32 n. 2, p. 173-178en_US
dc.identifier.issn1386-6532en_US
dc.identifier.urihttp://hdl.handle.net/10722/162773-
dc.description.abstractAfter hematopoietic cell transplantation (HCT), hepatitis due to hepatitis B virus (HBV) rarely occurred beyond the initial 12 months after transplantation. We investigated the cause of "late" hepatitis due to HBV infection in two recipients after allogeneic HCT. Two male patients with acute myeloid leukemia and light chain myeloma, respectively, developed HBV-related hepatitis more than 2 years after HCT. All serum samples collected from the recipients, donors and their respective spouses were tested for HBV DNA by nested PCR, and if positive further quantified by Digene Hybrid Capture assay II. The HBV genotype was determined by PCR and sequencing. Genotypic analysis suggested that the cause of "late" hepatitis was due to acute HBV infection transmitted from their respective spouse. Our findings suggested that sexual precautions should be taken in these patients after HCT. Alternatively, or even additionally, active vaccination should be delivered to these patients once they have lost their HBV immunity. © 2004 Published by Elsevier B.V.en_US
dc.languageengen_US
dc.publisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/jcven_US
dc.relation.ispartofJournal of Clinical Virologyen_US
dc.rightsJournal of Clinical Virology. Copyright © Elsevier BV.-
dc.subject.meshAdulten_US
dc.subject.meshDna, Viral - Analysisen_US
dc.subject.meshFemaleen_US
dc.subject.meshHematopoietic Stem Cell Transplantation - Adverse Effectsen_US
dc.subject.meshHepatitis B - Immunology - Transmissionen_US
dc.subject.meshHepatitis B Antibodies - Blooden_US
dc.subject.meshHepatitis B Surface Antigens - Immunologyen_US
dc.subject.meshHepatitis B Virus - Classification - Genetics - Immunologyen_US
dc.subject.meshHeterosexualityen_US
dc.subject.meshHumansen_US
dc.subject.meshImmunityen_US
dc.subject.meshMaleen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshPolymerase Chain Reactionen_US
dc.subject.meshSexually Transmitted Diseases, Viral - Immunology - Transmission - Virologyen_US
dc.subject.meshTransplantation, Homologous - Adverse Effectsen_US
dc.titleSexual transmission of hepatitis B infection despite the presence of hepatitis B virus immunity in recipients of allogeneic bone marrow transplantationen_US
dc.typeArticleen_US
dc.identifier.emailKwong, YL:ylkwong@hku.hken_US
dc.identifier.emailLiang, R:rliang@hku.hken_US
dc.identifier.authorityKwong, YL=rp00358en_US
dc.identifier.authorityLiang, R=rp00345en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1016/j.jcv.2004.08.003en_US
dc.identifier.pmid15653422-
dc.identifier.scopuseid_2-s2.0-11844307178en_US
dc.identifier.hkuros121174-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-11844307178&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume32en_US
dc.identifier.issue2en_US
dc.identifier.spage173en_US
dc.identifier.epage178en_US
dc.identifier.isiWOS:000227002100014-
dc.publisher.placeNetherlandsen_US
dc.identifier.scopusauthoridHui, CK=7202876933en_US
dc.identifier.scopusauthoridYu, J=37053320100en_US
dc.identifier.scopusauthoridAu, WY=7202383089en_US
dc.identifier.scopusauthoridZhang, HY=8965962000en_US
dc.identifier.scopusauthoridBartholomeusz, A=6701915061en_US
dc.identifier.scopusauthoridLocarnini, S=35953095500en_US
dc.identifier.scopusauthoridKwong, YL=7102818954en_US
dc.identifier.scopusauthoridLiang, R=26643224900en_US
dc.identifier.scopusauthoridLau, GKK=7102301257en_US

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