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Article: Independent and incremental prognostic value of early mitral annulus velocity in patients with impaired left ventricular systolic function

TitleIndependent and incremental prognostic value of early mitral annulus velocity in patients with impaired left ventricular systolic function
Authors
Issue Date2005
PublisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/jac
Citation
Journal Of The American College Of Cardiology, 2005, v. 45 n. 2, p. 272-277 How to Cite?
AbstractThis study sought to investigate the incremental prognostic value of non-invasive measures of early myocardial relaxation and left ventricular diastolic pressure (LVDP) in patients with impaired left ventricular (LV) systolic function. The early diastolic mitral annulus velocity (Em) reflects myocardial relaxation, and the combined ratio of the early transmitral flow velocity (E) to Em (E/Em) >15 correlates well with elevated mean LVDP. It is unknown if these new indexes will predict poorer survival in patients with LV systolic dysfunction. Echocardiograms were prospectively obtained in 182 patients with impaired LV systolic function, defined as an LV ejection fraction <0.50. The end point was cardiac mortality. The majority of this patient sample (80%) has been reported on in a previous publication. After a median 48 months' follow-up, Em emerged as an independent predictor of survival (hazard ratio 0.61, 95% confidence interval 0.45 to 0.82). An Em <3 cm/s was associated with a significantly excess mortality (log-rank statistic 9.36, p = 0.002), and this measurement added incremental prognostic value to standard indexes of systolic or diastolic function, including a deceleration time <140 ms and an E/Em >15 (p = 0.038). Early diastolic mitral annulus velocity is a powerful predictor of cardiac mortality in patients with LV systolic impairment; Em <3 cm/s emerged as the best prognosticator in long-term follow-up, incremental to other clinical or echocardiographic variables, including the ratio E/Em. © 2005 by the American College of Cardiology Foundation.
Persistent Identifierhttp://hdl.handle.net/10722/162772
ISSN
2015 Impact Factor: 17.759
2015 SCImago Journal Rankings: 10.097
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorWang, Men_US
dc.contributor.authorYip, Gen_US
dc.contributor.authorYu, CMen_US
dc.contributor.authorZhang, Qen_US
dc.contributor.authorZhang, Yen_US
dc.contributor.authorTse, Den_US
dc.contributor.authorKong, SLen_US
dc.contributor.authorSanderson, JEen_US
dc.date.accessioned2012-09-05T05:23:18Z-
dc.date.available2012-09-05T05:23:18Z-
dc.date.issued2005en_US
dc.identifier.citationJournal Of The American College Of Cardiology, 2005, v. 45 n. 2, p. 272-277en_US
dc.identifier.issn0735-1097en_US
dc.identifier.urihttp://hdl.handle.net/10722/162772-
dc.description.abstractThis study sought to investigate the incremental prognostic value of non-invasive measures of early myocardial relaxation and left ventricular diastolic pressure (LVDP) in patients with impaired left ventricular (LV) systolic function. The early diastolic mitral annulus velocity (Em) reflects myocardial relaxation, and the combined ratio of the early transmitral flow velocity (E) to Em (E/Em) >15 correlates well with elevated mean LVDP. It is unknown if these new indexes will predict poorer survival in patients with LV systolic dysfunction. Echocardiograms were prospectively obtained in 182 patients with impaired LV systolic function, defined as an LV ejection fraction <0.50. The end point was cardiac mortality. The majority of this patient sample (80%) has been reported on in a previous publication. After a median 48 months' follow-up, Em emerged as an independent predictor of survival (hazard ratio 0.61, 95% confidence interval 0.45 to 0.82). An Em <3 cm/s was associated with a significantly excess mortality (log-rank statistic 9.36, p = 0.002), and this measurement added incremental prognostic value to standard indexes of systolic or diastolic function, including a deceleration time <140 ms and an E/Em >15 (p = 0.038). Early diastolic mitral annulus velocity is a powerful predictor of cardiac mortality in patients with LV systolic impairment; Em <3 cm/s emerged as the best prognosticator in long-term follow-up, incremental to other clinical or echocardiographic variables, including the ratio E/Em. © 2005 by the American College of Cardiology Foundation.en_US
dc.languageengen_US
dc.publisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/jacen_US
dc.relation.ispartofJournal of the American College of Cardiologyen_US
dc.subject.meshAgeden_US
dc.subject.meshBlood Flow Velocity - Physiologyen_US
dc.subject.meshDiastole - Physiologyen_US
dc.subject.meshFemaleen_US
dc.subject.meshFollow-Up Studiesen_US
dc.subject.meshHumansen_US
dc.subject.meshMaleen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshMitral Valve - Physiopathology - Ultrasonographyen_US
dc.subject.meshPredictive Value Of Testsen_US
dc.subject.meshPrognosisen_US
dc.subject.meshSurvival Rateen_US
dc.subject.meshSystole - Physiologyen_US
dc.subject.meshVentricular Dysfunction, Left - Mortality - Physiopathology - Ultrasonographyen_US
dc.titleIndependent and incremental prognostic value of early mitral annulus velocity in patients with impaired left ventricular systolic functionen_US
dc.typeArticleen_US
dc.identifier.emailWang, M:meiwang@hkucc.hku.hken_US
dc.identifier.authorityWang, M=rp00281en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1016/j.jacc.2004.09.059en_US
dc.identifier.pmid15653027-
dc.identifier.scopuseid_2-s2.0-11844286998en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-11844286998&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume45en_US
dc.identifier.issue2en_US
dc.identifier.spage272en_US
dc.identifier.epage277en_US
dc.identifier.isiWOS:000226437900015-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridWang, M=7406690398en_US
dc.identifier.scopusauthoridYip, G=7006525328en_US
dc.identifier.scopusauthoridYu, CM=7404976646en_US
dc.identifier.scopusauthoridZhang, Q=7407966512en_US
dc.identifier.scopusauthoridZhang, Y=7601312580en_US
dc.identifier.scopusauthoridTse, D=35882819000en_US
dc.identifier.scopusauthoridKong, SL=7203044824en_US
dc.identifier.scopusauthoridSanderson, JE=7202371250en_US

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