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Article: Chronic myeloid leukemia in an adolescent with Ollier''s disease after intensive X-ray exposure

TitleChronic myeloid leukemia in an adolescent with Ollier''s disease after intensive X-ray exposure
Authors
Issue Date2004
PublisherInforma Healthcare. The Journal's web site is located at http://informahealthcare.com/loi/lal
Citation
Leukemia And Lymphoma, 2004, v. 45 n. 3, p. 613-616 How to Cite?
AbstractWe report a 19-year-old man with Ollier's disease with multiple orthopedic procedures performed for leg length discrepancy; who developed chronic myeloid leukemia presenting with intramuscular hematoma. His symptoms resolved with cytoreductive treatment by hydroxyurea. Cytogenetic and molecular investigations showed a complex Philadelphia translocation t(9;22;13) (q34;q11.2;q12), with predominance of e1a2 BCR/ABL splicing and deletion of reciprocal der(9) ABL/BCR locus, all suggesting poor prognosis. The cumulative X-ray exposure from repeated operations from the age of 7 to 12 years was estimated to be around 16 mSv, approximately the dose of 720 chest X rays. Literature review showed two other cases of leukemia occurring in patients with multiple enchondromatosis. Although the development of CML in this young patient might be related partly to genetic defects, the repeated radiation exposure, especially at young age and directly on the marrow tissue in the long bones, might also be an important pathogenetic factor.
Persistent Identifierhttp://hdl.handle.net/10722/162760
ISSN
2015 Impact Factor: 3.093
2015 SCImago Journal Rankings: 1.202
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorAu, WYen_US
dc.contributor.authorOoi, GCen_US
dc.contributor.authorMa, SKen_US
dc.contributor.authorWan, TSKen_US
dc.contributor.authorKwong, YLen_US
dc.date.accessioned2012-09-05T05:23:08Z-
dc.date.available2012-09-05T05:23:08Z-
dc.date.issued2004en_US
dc.identifier.citationLeukemia And Lymphoma, 2004, v. 45 n. 3, p. 613-616en_US
dc.identifier.issn1042-8194en_US
dc.identifier.urihttp://hdl.handle.net/10722/162760-
dc.description.abstractWe report a 19-year-old man with Ollier's disease with multiple orthopedic procedures performed for leg length discrepancy; who developed chronic myeloid leukemia presenting with intramuscular hematoma. His symptoms resolved with cytoreductive treatment by hydroxyurea. Cytogenetic and molecular investigations showed a complex Philadelphia translocation t(9;22;13) (q34;q11.2;q12), with predominance of e1a2 BCR/ABL splicing and deletion of reciprocal der(9) ABL/BCR locus, all suggesting poor prognosis. The cumulative X-ray exposure from repeated operations from the age of 7 to 12 years was estimated to be around 16 mSv, approximately the dose of 720 chest X rays. Literature review showed two other cases of leukemia occurring in patients with multiple enchondromatosis. Although the development of CML in this young patient might be related partly to genetic defects, the repeated radiation exposure, especially at young age and directly on the marrow tissue in the long bones, might also be an important pathogenetic factor.en_US
dc.languageengen_US
dc.publisherInforma Healthcare. The Journal's web site is located at http://informahealthcare.com/loi/lalen_US
dc.relation.ispartofLeukemia and Lymphomaen_US
dc.rightsLeukemia and Lymphoma. Copyright © Informa Healthcare.-
dc.subject.meshAdulten_US
dc.subject.meshChromosome Aberrationsen_US
dc.subject.meshCytogenetic Analysisen_US
dc.subject.meshEnchondromatosis - Complications - Radiography - Surgeryen_US
dc.subject.meshHematomaen_US
dc.subject.meshHumansen_US
dc.subject.meshLeukemia, Myelogenous, Chronic, Bcr-Abl Positive - Etiologyen_US
dc.subject.meshMaleen_US
dc.subject.meshMutationen_US
dc.subject.meshRadiation Dosageen_US
dc.subject.meshX-Rays - Adverse Effectsen_US
dc.titleChronic myeloid leukemia in an adolescent with Ollier''s disease after intensive X-ray exposureen_US
dc.typeArticleen_US
dc.identifier.emailKwong, YL:ylkwong@hku.hken_US
dc.identifier.authorityKwong, YL=rp00358en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1080/10428190310001602381en_US
dc.identifier.pmid15160927-
dc.identifier.scopuseid_2-s2.0-1042268881en_US
dc.identifier.hkuros87927-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-1042268881&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume45en_US
dc.identifier.issue3en_US
dc.identifier.spage613en_US
dc.identifier.epage616en_US
dc.identifier.isiWOS:000187022400026-
dc.publisher.placeUnited Kingdomen_US
dc.identifier.scopusauthoridAu, WY=7202383089en_US
dc.identifier.scopusauthoridOoi, GC=7006176119en_US
dc.identifier.scopusauthoridMa, SK=9042504200en_US
dc.identifier.scopusauthoridWan, TSK=25623981600en_US
dc.identifier.scopusauthoridKwong, YL=7102818954en_US

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