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Article: SARS: Prognosis, outcome and sequelae

TitleSARS: Prognosis, outcome and sequelae
Authors
Issue Date2003
PublisherBlackwell Publishing Asia. The Journal's web site is located at http://www.blackwellpublishing.com/journals/RES
Citation
Respirology, 2003, v. 8, p. S36-S40 How to Cite?
AbstractSevere acute respiratory syndrome (SARS) is associated with considerable morbidity and mortality in the acute phase. Worldwide case fatality rate is 11% (range 7 to 27%) for the most severely affected regions. Several adverse prognostic factors have been identified, including advanced age, presence of comorbidity, higher lactose dehydrogenase levels and initial neutrophil count, but the impact of viral and other host factors on outcome is unknown. Published data on sequelae of SARS are limited. Clinical follow-up of patients who recovered from SARS has demonstrated radiological, functional and psychological abnormalities of varying degrees. In the early rehabilitation phase, many complained of limitations in physical function from general weakness and/or shortness of breath. In a small series of subjects who underwent CT scan of the chest, over half showed some patchy changes consistent with pulmonary fibrosis. Lung function testing at 6-8 weeks after hospital discharge showed mild or moderate restrictive pattern consistent with muscle weakness in 6-20% of subjects. Mild decrease in carbon monoxide diffusing capacity was detected in a minority of subjects. Preliminary evidence suggests that these lung function abnormalities will improve over time. Psychobehavioural problems of anxiety and/or depression were not uncommon in the early recovery phase, and improved over time in the majority of patients. Avascular necrosis of the hip has been reported as another complication. The long-term sequelae of SARS are still largely unknown. It is important to follow up these patients to detect and appropriately manage any persistent or emerging long-term sequelae in the physical, psychological and social domains.
Persistent Identifierhttp://hdl.handle.net/10722/162745
ISSN
2015 Impact Factor: 3.078
2015 SCImago Journal Rankings: 1.157
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorChan, KSen_US
dc.contributor.authorZheng, JPen_US
dc.contributor.authorMok, YWen_US
dc.contributor.authorLi, YMen_US
dc.contributor.authorLiu, YNen_US
dc.contributor.authorChu, CMen_US
dc.contributor.authorIp, MSen_US
dc.date.accessioned2012-09-05T05:23:03Z-
dc.date.available2012-09-05T05:23:03Z-
dc.date.issued2003en_US
dc.identifier.citationRespirology, 2003, v. 8, p. S36-S40en_US
dc.identifier.issn1323-7799en_US
dc.identifier.urihttp://hdl.handle.net/10722/162745-
dc.description.abstractSevere acute respiratory syndrome (SARS) is associated with considerable morbidity and mortality in the acute phase. Worldwide case fatality rate is 11% (range 7 to 27%) for the most severely affected regions. Several adverse prognostic factors have been identified, including advanced age, presence of comorbidity, higher lactose dehydrogenase levels and initial neutrophil count, but the impact of viral and other host factors on outcome is unknown. Published data on sequelae of SARS are limited. Clinical follow-up of patients who recovered from SARS has demonstrated radiological, functional and psychological abnormalities of varying degrees. In the early rehabilitation phase, many complained of limitations in physical function from general weakness and/or shortness of breath. In a small series of subjects who underwent CT scan of the chest, over half showed some patchy changes consistent with pulmonary fibrosis. Lung function testing at 6-8 weeks after hospital discharge showed mild or moderate restrictive pattern consistent with muscle weakness in 6-20% of subjects. Mild decrease in carbon monoxide diffusing capacity was detected in a minority of subjects. Preliminary evidence suggests that these lung function abnormalities will improve over time. Psychobehavioural problems of anxiety and/or depression were not uncommon in the early recovery phase, and improved over time in the majority of patients. Avascular necrosis of the hip has been reported as another complication. The long-term sequelae of SARS are still largely unknown. It is important to follow up these patients to detect and appropriately manage any persistent or emerging long-term sequelae in the physical, psychological and social domains.en_US
dc.languageengen_US
dc.publisherBlackwell Publishing Asia. The Journal's web site is located at http://www.blackwellpublishing.com/journals/RESen_US
dc.relation.ispartofRespirologyen_US
dc.subject.meshHumansen_US
dc.subject.meshLung Diseases - Virologyen_US
dc.subject.meshPrognosisen_US
dc.subject.meshSevere Acute Respiratory Syndrome - Complications - Diagnosis - Mortality - Therapyen_US
dc.subject.meshTreatment Outcomeen_US
dc.titleSARS: Prognosis, outcome and sequelaeen_US
dc.typeArticleen_US
dc.identifier.emailIp, MS:msmip@hku.hken_US
dc.identifier.authorityIp, MS=rp00347en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1046/j.1440-1843.2003.00522.xen_US
dc.identifier.pmid15018132-
dc.identifier.scopuseid_2-s2.0-0347228947en_US
dc.identifier.hkuros86224-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0347228947&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume8en_US
dc.identifier.spageS36en_US
dc.identifier.epageS40en_US
dc.identifier.isiWOS:000187345100009-
dc.publisher.placeAustraliaen_US
dc.identifier.scopusauthoridChan, KS=7406031627en_US
dc.identifier.scopusauthoridZheng, JP=7403975931en_US
dc.identifier.scopusauthoridMok, YW=7006420050en_US
dc.identifier.scopusauthoridLi, YM=17434341700en_US
dc.identifier.scopusauthoridLiu, YN=8582447800en_US
dc.identifier.scopusauthoridChu, CM=7404345558en_US
dc.identifier.scopusauthoridIp, MS=7102423259en_US

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