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Article: Nontuberculous mycobacterial infections in Chinese hematopoietic stem cell transplantation recipients

TitleNontuberculous mycobacterial infections in Chinese hematopoietic stem cell transplantation recipients
Authors
Issue Date2003
PublisherNature Publishing Group. The Journal's web site is located at http://www.nature.com/bmt
Citation
Bone Marrow Transplantation, 2003, v. 32 n. 7, p. 709-714 How to Cite?
AbstractBetween 1995 and 2002, nine cases of nontuberculous mycobacterium (NTM) were isolated from 462 allogeneic stem cell transplant (SCT) recipients (1.9%), and none from 139 autologous cases. They included three cases each of Mycobacterium fortuitum and M. chelonae, and single cases of M. scrofalaceum, M. gordonnae and M. avium complex. Seven cases were respiratory, including five cases requiring treatment, and two involved infected catheters and vascular conduits. Compared with nine cases of mycobacterium tuberculosis (MTB) isolated in the same period, NTM isolation occurred later after HSCT and involved more unrelated donors. Important risk factors for NTM infection included significant aGVHD (P=0.043), leukemia relapse (P=0.022), MUD and mismatch SCT (P<0.001) and existence of BO (P<0.001). Coinfection with aspergillus was common. Invasive NTM disease required prolonged antimicrobial treatment in five cases due to M. fortuitum and M. chelonae. With better MTB prophylaxis, intensive immunosuppression and better awareness, NTM has become an emerging threat in oriental allogeneic HSCT recipients. The cutoff between colonization and infection, and the threshold for starting treatment is unclear. NTM isolation is a marker for severe immunosuppression and poor prognosis. When there is doubt over species identity or extent of infection, broad-spectrum cover may be prudent.
Persistent Identifierhttp://hdl.handle.net/10722/162726
ISSN
2015 Impact Factor: 3.636
2015 SCImago Journal Rankings: 1.585
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorAu, WYen_US
dc.contributor.authorCheng, VCCen_US
dc.contributor.authorHo, PLen_US
dc.contributor.authorYuen, KYen_US
dc.contributor.authorHung, Ien_US
dc.contributor.authorMa, SYen_US
dc.contributor.authorLie, AKWen_US
dc.contributor.authorLiang, Ren_US
dc.contributor.authorKwong, YLen_US
dc.date.accessioned2012-09-05T05:22:48Z-
dc.date.available2012-09-05T05:22:48Z-
dc.date.issued2003en_US
dc.identifier.citationBone Marrow Transplantation, 2003, v. 32 n. 7, p. 709-714en_US
dc.identifier.issn0268-3369en_US
dc.identifier.urihttp://hdl.handle.net/10722/162726-
dc.description.abstractBetween 1995 and 2002, nine cases of nontuberculous mycobacterium (NTM) were isolated from 462 allogeneic stem cell transplant (SCT) recipients (1.9%), and none from 139 autologous cases. They included three cases each of Mycobacterium fortuitum and M. chelonae, and single cases of M. scrofalaceum, M. gordonnae and M. avium complex. Seven cases were respiratory, including five cases requiring treatment, and two involved infected catheters and vascular conduits. Compared with nine cases of mycobacterium tuberculosis (MTB) isolated in the same period, NTM isolation occurred later after HSCT and involved more unrelated donors. Important risk factors for NTM infection included significant aGVHD (P=0.043), leukemia relapse (P=0.022), MUD and mismatch SCT (P<0.001) and existence of BO (P<0.001). Coinfection with aspergillus was common. Invasive NTM disease required prolonged antimicrobial treatment in five cases due to M. fortuitum and M. chelonae. With better MTB prophylaxis, intensive immunosuppression and better awareness, NTM has become an emerging threat in oriental allogeneic HSCT recipients. The cutoff between colonization and infection, and the threshold for starting treatment is unclear. NTM isolation is a marker for severe immunosuppression and poor prognosis. When there is doubt over species identity or extent of infection, broad-spectrum cover may be prudent.en_US
dc.languageengen_US
dc.publisherNature Publishing Group. The Journal's web site is located at http://www.nature.com/bmten_US
dc.relation.ispartofBone Marrow Transplantationen_US
dc.subject.meshAdulten_US
dc.subject.meshAspergillosis - Etiologyen_US
dc.subject.meshCatheterization - Adverse Effectsen_US
dc.subject.meshChina - Epidemiologyen_US
dc.subject.meshFemaleen_US
dc.subject.meshHematopoietic Stem Cell Transplantation - Adverse Effectsen_US
dc.subject.meshHumansen_US
dc.subject.meshImmunosuppression - Adverse Effectsen_US
dc.subject.meshMaleen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshMycobacterium Infections - Etiology - Microbiologyen_US
dc.subject.meshRespiratory Tract Infections - Etiology - Microbiologyen_US
dc.subject.meshRetrospective Studiesen_US
dc.subject.meshRisk Factorsen_US
dc.subject.meshTreatment Outcomeen_US
dc.titleNontuberculous mycobacterial infections in Chinese hematopoietic stem cell transplantation recipientsen_US
dc.typeArticleen_US
dc.identifier.emailAu, WY: auwing@HKUCC.hku.hken_US
dc.identifier.emailCheng, VCC: vcccheng@HKUCC.hku.hken_US
dc.identifier.emailHo, PL: plho@hkucc.hku.hken_US
dc.identifier.emailYuen, KY: kyyuen@hkucc.hku.hken_US
dc.identifier.emailHung, I: ivanhung@hkucc.hku.hken_US
dc.identifier.emailLie, AKW: akwlie@HKUCC.hku.hk-
dc.identifier.emailLiang, R: rliang@hku.hk-
dc.identifier.emailKwong, YL: ylkwong@hku.hk-
dc.identifier.authorityHo, PL=rp00406en_US
dc.identifier.authorityYuen, KY=rp00366en_US
dc.identifier.authorityHung, I=rp00508en_US
dc.identifier.authorityLiang, R=rp00345en_US
dc.identifier.authorityKwong, YL=rp00358en_US
dc.description.naturelink_to_OA_fulltexten_US
dc.identifier.doi10.1038/sj.bmt.1704210en_US
dc.identifier.pmid13130319-
dc.identifier.scopuseid_2-s2.0-0141893257en_US
dc.identifier.hkuros87673-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0141893257&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume32en_US
dc.identifier.issue7en_US
dc.identifier.spage709en_US
dc.identifier.epage714en_US
dc.identifier.isiWOS:000185335100011-
dc.publisher.placeUnited Kingdomen_US
dc.identifier.scopusauthoridAu, WY=7202383089en_US
dc.identifier.scopusauthoridCheng, VCC=23670479400en_US
dc.identifier.scopusauthoridHo, PL=7402211363en_US
dc.identifier.scopusauthoridYuen, KY=36078079100en_US
dc.identifier.scopusauthoridHung, I=7006103457en_US
dc.identifier.scopusauthoridMa, SY=7403725725en_US
dc.identifier.scopusauthoridLie, AKW=24284842400en_US
dc.identifier.scopusauthoridLiang, R=26643224900en_US
dc.identifier.scopusauthoridKwong, YL=7102818954en_US
dc.customcontrol.immutablesml 130529-

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