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Article: Anaplastic large cell lymphoma presenting as a pleural effusion and mimicking primary effusion lymphoma: A report of 2 cases

TitleAnaplastic large cell lymphoma presenting as a pleural effusion and mimicking primary effusion lymphoma: A report of 2 cases
Authors
Issue Date2003
PublisherScience Printers and Publishers, Inc. The Journal's web site is located at http://www.acta-cytol.com
Citation
Acta Cytologica, 2003, v. 47 n. 5, p. 809-816 How to Cite?
AbstractBACKGROUND: Systemic anaplastic large cell lymphoma (ALCL) is predominantly a nodal disease, but extranodal involvement can occur during the disease course or as the primary presentation. We report two rare cases of ALCL presenting with a pleural effusion, mimicking primary effusion lymphoma (PEL). CASES: Two patients, a 47-year-old woman and an 81-year-old man, presented with a pleural effusion for investigation. The pleural fluid contained abundant, large, lymphoid cells with marked nuclear atypia. These neoplastic cells strongly expressed CD30 and EMA and showed a T-cell phenotype (CD3+CD45RO+ for case 1 and CD4+ for case 2). Case 1, in addition, showed ALK1 expression. The tumor cells in both cases were negative for human herpes virus type 8 (HHV8) and Epstein-Barr virus (EBV). ALCL shows overlapping cytologic features with PEL, but the T-cell phenotype, ALK1 expression in case 1, lack of association with HHV8 and EBV, HIV seronegativity and subsequent discovery of nodal disease in case 2 were all in favor of ALCL over PEL. CONCLUSION: In rare cases a pleural effusion is the presenting feature of ALCL, and distinction from PEL depends on correlation with clinical findings, detailed immunophenotyping and study of the status of HHV8 and EBV.
Persistent Identifierhttp://hdl.handle.net/10722/162722
ISSN
2013 Impact Factor: 1.562
2015 SCImago Journal Rankings: 0.486
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorChan, ACLen_US
dc.contributor.authorChan, JKCen_US
dc.contributor.authorYan, KWen_US
dc.contributor.authorKwong, YLen_US
dc.date.accessioned2012-09-05T05:22:47Z-
dc.date.available2012-09-05T05:22:47Z-
dc.date.issued2003en_US
dc.identifier.citationActa Cytologica, 2003, v. 47 n. 5, p. 809-816en_US
dc.identifier.issn0001-5547en_US
dc.identifier.urihttp://hdl.handle.net/10722/162722-
dc.description.abstractBACKGROUND: Systemic anaplastic large cell lymphoma (ALCL) is predominantly a nodal disease, but extranodal involvement can occur during the disease course or as the primary presentation. We report two rare cases of ALCL presenting with a pleural effusion, mimicking primary effusion lymphoma (PEL). CASES: Two patients, a 47-year-old woman and an 81-year-old man, presented with a pleural effusion for investigation. The pleural fluid contained abundant, large, lymphoid cells with marked nuclear atypia. These neoplastic cells strongly expressed CD30 and EMA and showed a T-cell phenotype (CD3+CD45RO+ for case 1 and CD4+ for case 2). Case 1, in addition, showed ALK1 expression. The tumor cells in both cases were negative for human herpes virus type 8 (HHV8) and Epstein-Barr virus (EBV). ALCL shows overlapping cytologic features with PEL, but the T-cell phenotype, ALK1 expression in case 1, lack of association with HHV8 and EBV, HIV seronegativity and subsequent discovery of nodal disease in case 2 were all in favor of ALCL over PEL. CONCLUSION: In rare cases a pleural effusion is the presenting feature of ALCL, and distinction from PEL depends on correlation with clinical findings, detailed immunophenotyping and study of the status of HHV8 and EBV.en_US
dc.languageengen_US
dc.publisherScience Printers and Publishers, Inc. The Journal's web site is located at http://www.acta-cytol.comen_US
dc.relation.ispartofActa Cytologicaen_US
dc.subject.meshAgeden_US
dc.subject.meshAged, 80 And Overen_US
dc.subject.meshAntigens, Cd - Metabolismen_US
dc.subject.meshDiagnosis, Differentialen_US
dc.subject.meshFemaleen_US
dc.subject.meshHumansen_US
dc.subject.meshImmunoenzyme Techniquesen_US
dc.subject.meshImmunophenotypingen_US
dc.subject.meshLymphoma, Large-Cell, Anaplastic - Diagnosis - Enzymologyen_US
dc.subject.meshMaleen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshPleural Effusion, Malignant - Diagnosis - Enzymologyen_US
dc.subject.meshProtein-Tyrosine Kinases - Metabolismen_US
dc.subject.meshReceptor Protein-Tyrosine Kinasesen_US
dc.titleAnaplastic large cell lymphoma presenting as a pleural effusion and mimicking primary effusion lymphoma: A report of 2 casesen_US
dc.typeArticleen_US
dc.identifier.emailKwong, YL:ylkwong@hku.hken_US
dc.identifier.authorityKwong, YL=rp00358en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.pmid14526684-
dc.identifier.scopuseid_2-s2.0-0141706920en_US
dc.identifier.hkuros87922-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0141706920&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume47en_US
dc.identifier.issue5en_US
dc.identifier.spage809en_US
dc.identifier.epage816en_US
dc.identifier.isiWOS:000185332200018-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridChan, ACL=16047349300en_US
dc.identifier.scopusauthoridChan, JKC=26430517500en_US
dc.identifier.scopusauthoridYan, KW=36864209000en_US
dc.identifier.scopusauthoridKwong, YL=7102818954en_US

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