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Article: Enhanced expression of transforming growth factor-beta isoforms in the neural tube of embryos derived from diabetic mice exposed to cyclophosphamide

TitleEnhanced expression of transforming growth factor-beta isoforms in the neural tube of embryos derived from diabetic mice exposed to cyclophosphamide
Authors
Issue Date2003
PublisherElsevier Ireland Ltd. The Journal's web site is located at http://www.elsevier.com/locate/neulet
Citation
Neuroscience Letters, 2003, v. 351 n. 1, p. 51-55 How to Cite?
AbstractWe analyzed the expression pattern of transforming growth factor-β isoforms (TGF-β1, TGF-β2 and TGF-β3) in the developing brain of embryos derived from the normal and diabetic mice exposed to cyclophosphamide (CP), a cytotoxic teratogen. The CP-treated diabetic embryos showed significantly more TGF-β1 and TGF-β2 immunoreactive cells in the regions of telencephalon and diencephalon in comparison to that of CP-treated non-diabetic embryos. Moreover, no cells expressing TGF-β isoforms were detectable in the developing brain of normal and diabetic embryos. The mRNA expression levels of TGF-β isoforms were found to be significantly increased in the developing brain of CP-treated diabetic embryos compared to that of CP-treated non-diabetic embryos as measured by quantitative real time reverse transcription-polymerase chain reaction. The enhanced expression levels of TGF-β isoforms appear to be associated with the increased frequency of neural tube defects observed in the diabetic embryos exposed to CP. © 2003 Elsevier Ireland Ltd. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/162720
ISSN
2015 Impact Factor: 2.107
2015 SCImago Journal Rankings: 1.035
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorLian, Qen_US
dc.contributor.authorSamuel, TSWen_US
dc.contributor.authorDheen, STen_US
dc.date.accessioned2012-09-05T05:22:47Z-
dc.date.available2012-09-05T05:22:47Z-
dc.date.issued2003en_US
dc.identifier.citationNeuroscience Letters, 2003, v. 351 n. 1, p. 51-55en_US
dc.identifier.issn0304-3940en_US
dc.identifier.urihttp://hdl.handle.net/10722/162720-
dc.description.abstractWe analyzed the expression pattern of transforming growth factor-β isoforms (TGF-β1, TGF-β2 and TGF-β3) in the developing brain of embryos derived from the normal and diabetic mice exposed to cyclophosphamide (CP), a cytotoxic teratogen. The CP-treated diabetic embryos showed significantly more TGF-β1 and TGF-β2 immunoreactive cells in the regions of telencephalon and diencephalon in comparison to that of CP-treated non-diabetic embryos. Moreover, no cells expressing TGF-β isoforms were detectable in the developing brain of normal and diabetic embryos. The mRNA expression levels of TGF-β isoforms were found to be significantly increased in the developing brain of CP-treated diabetic embryos compared to that of CP-treated non-diabetic embryos as measured by quantitative real time reverse transcription-polymerase chain reaction. The enhanced expression levels of TGF-β isoforms appear to be associated with the increased frequency of neural tube defects observed in the diabetic embryos exposed to CP. © 2003 Elsevier Ireland Ltd. All rights reserved.en_US
dc.languageengen_US
dc.publisherElsevier Ireland Ltd. The Journal's web site is located at http://www.elsevier.com/locate/neuleten_US
dc.relation.ispartofNeuroscience Lettersen_US
dc.subject.meshAnimalsen_US
dc.subject.meshCentral Nervous System - Embryology - Metabolismen_US
dc.subject.meshCyclophosphamide - Toxicityen_US
dc.subject.meshDiabetes Mellitus, Experimental - Metabolismen_US
dc.subject.meshEmbryo, Mammalian - Drug Effects - Metabolismen_US
dc.subject.meshFemaleen_US
dc.subject.meshImmunohistochemistryen_US
dc.subject.meshMiceen_US
dc.subject.meshPregnancyen_US
dc.subject.meshPregnancy In Diabetics - Metabolismen_US
dc.subject.meshProtein Isoforms - Metabolismen_US
dc.subject.meshReverse Transcriptase Polymerase Chain Reactionen_US
dc.subject.meshTeratogens - Toxicityen_US
dc.subject.meshTransforming Growth Factor Beta - Biosynthesisen_US
dc.subject.meshTransforming Growth Factor Beta1en_US
dc.subject.meshTransforming Growth Factor Beta2en_US
dc.subject.meshTransforming Growth Factor Beta3en_US
dc.titleEnhanced expression of transforming growth factor-beta isoforms in the neural tube of embryos derived from diabetic mice exposed to cyclophosphamideen_US
dc.typeArticleen_US
dc.identifier.emailLian, Q:qzlian@hkucc.hku.hken_US
dc.identifier.authorityLian, Q=rp00267en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1016/S0304-3940(03)00927-3en_US
dc.identifier.pmid14550911-
dc.identifier.scopuseid_2-s2.0-0141560307en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0141560307&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume351en_US
dc.identifier.issue1en_US
dc.identifier.spage51en_US
dc.identifier.epage55en_US
dc.identifier.isiWOS:000185863900013-
dc.publisher.placeIrelanden_US
dc.identifier.scopusauthoridLian, Q=7003399023en_US
dc.identifier.scopusauthoridSamuel, TSW=7005025166en_US
dc.identifier.scopusauthoridDheen, ST=6701666815en_US

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