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Article: Peak early diastolic mitral annulus velocity by tissue Doppler imaging adds independent and incremental prognostic value

TitlePeak early diastolic mitral annulus velocity by tissue Doppler imaging adds independent and incremental prognostic value
Authors
Issue Date2003
PublisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/jac
Citation
Journal Of The American College Of Cardiology, 2003, v. 41 n. 5, p. 820-826 How to Cite?
AbstractOBJECTIVES: The aim of this study was to ascertain if left ventricular mitral annulus velocities measured by tissue Doppler imaging (TDI) are more powerful predictors of outcome compared with clinical data and standard Doppler-echocardiographic parameters. BACKGROUND: Tissue Doppler imaging of basal or mitral annulus velocities provides rapid assessment of ventricular long axis function. But it is not known if TDI-derived velocities in systole and diastole add incremental value and are superior to the standard Doppler-echocardiographic measurements as a predictor of outcome. METHODS: The study population consisted of 518 subjects, 353 with cardiac disease and 165 normal subjects who had full Doppler two-dimensional-echocardiographic studies with measurement of mitral inflow velocities in early and late diastole, E-wave deceleration nine (DT), peak systolic mitral annular velocity (Sm) early and late diastolic mitral annular velocity (Em and Am) by TDI, early diastolic flow propagation velocity, and standard chamber dimensions. All subjects were followed up for two years. The end point was cardiac death. RESULTS: Tissue Doppler imaging mitral annulus systolic and diastolic velocities were all significantly lower in the non-survivors (all p < 0.05) as was DT (p = 0.024). In the Cox model the best predictors of mortality were Em, Sm, Am, left ventricular ejection fraction, left ventricular mass, and left atrial diameter in systole (LADs). By backward stepwise analysis Em and LADs were the strongest predictors. After forcing the TDI measurements into the covariate model with clinical and mitral DT <0.16 s, Em provided significant incremental value for predicting cardiac mortality (p = 0.004). CONCLUSIONS: Mitral annulus velocity measured by TDI in early diastole gives incremental predictive power for cardiac mortality compared to clinical data and standard echocardiographic measurements. This easily available measurement adds significant value in the clinical management of cardiac patients. © 2003 by the American College of Cardiology Foundation.
Persistent Identifierhttp://hdl.handle.net/10722/162683
ISSN
2015 Impact Factor: 17.759
2015 SCImago Journal Rankings: 10.097
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorWang, Men_US
dc.contributor.authorYip, GWKen_US
dc.contributor.authorWang, AYMen_US
dc.contributor.authorZhang, Yen_US
dc.contributor.authorHo, PYen_US
dc.contributor.authorTse, MKen_US
dc.contributor.authorLam, PKWen_US
dc.contributor.authorSanderson, JEen_US
dc.date.accessioned2012-09-05T05:22:19Z-
dc.date.available2012-09-05T05:22:19Z-
dc.date.issued2003en_US
dc.identifier.citationJournal Of The American College Of Cardiology, 2003, v. 41 n. 5, p. 820-826en_US
dc.identifier.issn0735-1097en_US
dc.identifier.urihttp://hdl.handle.net/10722/162683-
dc.description.abstractOBJECTIVES: The aim of this study was to ascertain if left ventricular mitral annulus velocities measured by tissue Doppler imaging (TDI) are more powerful predictors of outcome compared with clinical data and standard Doppler-echocardiographic parameters. BACKGROUND: Tissue Doppler imaging of basal or mitral annulus velocities provides rapid assessment of ventricular long axis function. But it is not known if TDI-derived velocities in systole and diastole add incremental value and are superior to the standard Doppler-echocardiographic measurements as a predictor of outcome. METHODS: The study population consisted of 518 subjects, 353 with cardiac disease and 165 normal subjects who had full Doppler two-dimensional-echocardiographic studies with measurement of mitral inflow velocities in early and late diastole, E-wave deceleration nine (DT), peak systolic mitral annular velocity (Sm) early and late diastolic mitral annular velocity (Em and Am) by TDI, early diastolic flow propagation velocity, and standard chamber dimensions. All subjects were followed up for two years. The end point was cardiac death. RESULTS: Tissue Doppler imaging mitral annulus systolic and diastolic velocities were all significantly lower in the non-survivors (all p < 0.05) as was DT (p = 0.024). In the Cox model the best predictors of mortality were Em, Sm, Am, left ventricular ejection fraction, left ventricular mass, and left atrial diameter in systole (LADs). By backward stepwise analysis Em and LADs were the strongest predictors. After forcing the TDI measurements into the covariate model with clinical and mitral DT <0.16 s, Em provided significant incremental value for predicting cardiac mortality (p = 0.004). CONCLUSIONS: Mitral annulus velocity measured by TDI in early diastole gives incremental predictive power for cardiac mortality compared to clinical data and standard echocardiographic measurements. This easily available measurement adds significant value in the clinical management of cardiac patients. © 2003 by the American College of Cardiology Foundation.en_US
dc.languageengen_US
dc.publisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/jacen_US
dc.relation.ispartofJournal of the American College of Cardiologyen_US
dc.subject.meshAdulten_US
dc.subject.meshAgeden_US
dc.subject.meshAged, 80 And Overen_US
dc.subject.meshAnalysis Of Varianceen_US
dc.subject.meshBlood Flow Velocityen_US
dc.subject.meshCase-Control Studiesen_US
dc.subject.meshCohort Studiesen_US
dc.subject.meshConfidence Intervalsen_US
dc.subject.meshDeathen_US
dc.subject.meshDiastole - Physiologyen_US
dc.subject.meshEchocardiography, Doppler - Methodsen_US
dc.subject.meshEchocardiography, Doppler, Pulsed - Methodsen_US
dc.subject.meshFemaleen_US
dc.subject.meshHemodynamics - Physiologyen_US
dc.subject.meshHumansen_US
dc.subject.meshMaleen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshMitral Valve - Physiology - Ultrasonographyen_US
dc.subject.meshPredictive Value Of Testsen_US
dc.subject.meshProbabilityen_US
dc.subject.meshPrognosisen_US
dc.subject.meshReference Valuesen_US
dc.subject.meshSeverity Of Illness Indexen_US
dc.subject.meshStroke Volumeen_US
dc.subject.meshSurvival Rateen_US
dc.subject.meshVentricular Dysfunction, Left - Mortality - Physiopathology - Ultrasonographyen_US
dc.titlePeak early diastolic mitral annulus velocity by tissue Doppler imaging adds independent and incremental prognostic valueen_US
dc.typeArticleen_US
dc.identifier.emailWang, M:meiwang@hkucc.hku.hken_US
dc.identifier.authorityWang, M=rp00281en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1016/S0735-1097(02)02921-2en_US
dc.identifier.pmid12628728-
dc.identifier.scopuseid_2-s2.0-0037420099en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0037420099&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume41en_US
dc.identifier.issue5en_US
dc.identifier.spage820en_US
dc.identifier.epage826en_US
dc.identifier.isiWOS:000181248000018-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridWang, M=7406690398en_US
dc.identifier.scopusauthoridYip, GWK=7006525328en_US
dc.identifier.scopusauthoridWang, AYM=13606226000en_US
dc.identifier.scopusauthoridZhang, Y=7601312580en_US
dc.identifier.scopusauthoridHo, PY=14019449500en_US
dc.identifier.scopusauthoridTse, MK=7103352624en_US
dc.identifier.scopusauthoridLam, PKW=35187264900en_US
dc.identifier.scopusauthoridSanderson, JE=7202371250en_US

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