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Article: Angiogenesis in ischaemic myocardium by intramyocardial autologous bone marrow mononuclear cell implantation

TitleAngiogenesis in ischaemic myocardium by intramyocardial autologous bone marrow mononuclear cell implantation
Authors
Issue Date2003
PublisherThe Lancet Publishing Group. The Journal's web site is located at http://www.elsevier.com/locate/lancet
Citation
Lancet, 2003, v. 361 n. 9351, p. 47-49 How to Cite?
Abstract
Results of experimental studies have shown that intramyocardial implantation of bone marrow cells induces neovascularisation and improves heart function after myocardial infarction. Our aim was to test this notion in people. We implanted autologous mononuclear bone marrow cells into the ischaemic myocardium of eight patients with severe ischaemic heart disease as guided by electromechanical mapping with a percutaneous catheter procedure. After 3 months of follow-up, there was improvement in symptoms, myocardial perfusion, and function at the ischaemic region on MRI. Future randomised, controlled studies are required to validate this initial encouraging result.
Persistent Identifierhttp://hdl.handle.net/10722/162681
ISSN
2013 Impact Factor: 39.207
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorTse, HFen_US
dc.contributor.authorKwong, YLen_US
dc.contributor.authorChan, JKFen_US
dc.contributor.authorLo, Gen_US
dc.contributor.authorHo, CLen_US
dc.contributor.authorLau, CPen_US
dc.date.accessioned2012-09-05T05:22:17Z-
dc.date.available2012-09-05T05:22:17Z-
dc.date.issued2003en_US
dc.identifier.citationLancet, 2003, v. 361 n. 9351, p. 47-49en_US
dc.identifier.issn0140-6736en_US
dc.identifier.urihttp://hdl.handle.net/10722/162681-
dc.description.abstractResults of experimental studies have shown that intramyocardial implantation of bone marrow cells induces neovascularisation and improves heart function after myocardial infarction. Our aim was to test this notion in people. We implanted autologous mononuclear bone marrow cells into the ischaemic myocardium of eight patients with severe ischaemic heart disease as guided by electromechanical mapping with a percutaneous catheter procedure. After 3 months of follow-up, there was improvement in symptoms, myocardial perfusion, and function at the ischaemic region on MRI. Future randomised, controlled studies are required to validate this initial encouraging result.en_US
dc.languageengen_US
dc.publisherThe Lancet Publishing Group. The Journal's web site is located at http://www.elsevier.com/locate/lanceten_US
dc.relation.ispartofLanceten_US
dc.subject.meshAgeden_US
dc.subject.meshBone Marrow Transplantation - Methodsen_US
dc.subject.meshFeasibility Studiesen_US
dc.subject.meshFemaleen_US
dc.subject.meshFlow Cytometryen_US
dc.subject.meshHumansen_US
dc.subject.meshMaleen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshMyocardial Ischemia - Therapyen_US
dc.subject.meshNeovascularization, Physiologicen_US
dc.subject.meshProspective Studiesen_US
dc.subject.meshTomography, Emission-Computed, Single-Photonen_US
dc.subject.meshTreatment Outcomeen_US
dc.titleAngiogenesis in ischaemic myocardium by intramyocardial autologous bone marrow mononuclear cell implantationen_US
dc.typeArticleen_US
dc.identifier.emailTse, HF:hftse@hkucc.hku.hken_US
dc.identifier.emailKwong, YL:ylkwong@hku.hken_US
dc.identifier.authorityTse, HF=rp00428en_US
dc.identifier.authorityKwong, YL=rp00358en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1016/S0140-6736(03)12111-3en_US
dc.identifier.pmid12517468en_US
dc.identifier.scopuseid_2-s2.0-0037417506en_US
dc.identifier.hkuros81898-
dc.identifier.hkuros87916-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0037417506&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume361en_US
dc.identifier.issue9351en_US
dc.identifier.spage47en_US
dc.identifier.epage49en_US
dc.identifier.isiWOS:000180191600022-
dc.publisher.placeUnited Kingdomen_US
dc.identifier.scopusauthoridTse, HF=7006070805en_US
dc.identifier.scopusauthoridKwong, YL=7102818954en_US
dc.identifier.scopusauthoridChan, JKF=7403287057en_US
dc.identifier.scopusauthoridLo, G=7101880732en_US
dc.identifier.scopusauthoridHo, CL=7404653628en_US
dc.identifier.scopusauthoridLau, CP=7401968501en_US

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