Article: Angiogenesis in ischaemic myocardium by intramyocardial autologous bone marrow mononuclear cell implantation

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TitleAngiogenesis in ischaemic myocardium by intramyocardial autologous bone marrow mononuclear cell implantation
AuthorsTse, HF1
Kwong, YL1
Chan, JKF2
Lo, G2
Ho, CL2
Lau, CP1
Issue Date2003
PublisherThe Lancet Publishing Group. The Journal's web site is located at http://www.elsevier.com/locate/lancet
CitationLancet, 2003, v. 361 n. 9351, p. 47-49 [How to Cite?]
DOI: http://dx.doi.org/10.1016/S0140-6736(03)12111-3
AbstractResults of experimental studies have shown that intramyocardial implantation of bone marrow cells induces neovascularisation and improves heart function after myocardial infarction. Our aim was to test this notion in people. We implanted autologous mononuclear bone marrow cells into the ischaemic myocardium of eight patients with severe ischaemic heart disease as guided by electromechanical mapping with a percutaneous catheter procedure. After 3 months of follow-up, there was improvement in symptoms, myocardial perfusion, and function at the ischaemic region on MRI. Future randomised, controlled studies are required to validate this initial encouraging result.
ISSN0140-6736
2011 Impact Factor: 38.278
2011 SCImago Journal Rankings: 1.486
DOIhttp://dx.doi.org/10.1016/S0140-6736(03)12111-3
ReferencesReferences in Scopus
DC Field
Value
dc.contributor.authorTse, HF
dc.contributor.authorKwong, YL
dc.contributor.authorChan, JKF
dc.contributor.authorLo, G
dc.contributor.authorHo, CL
dc.contributor.authorLau, CP
dc.date.accessioned2012-09-05T05:22:17Z
dc.date.available2012-09-05T05:22:17Z
dc.date.issued2003
dc.description.abstractResults of experimental studies have shown that intramyocardial implantation of bone marrow cells induces neovascularisation and improves heart function after myocardial infarction. Our aim was to test this notion in people. We implanted autologous mononuclear bone marrow cells into the ischaemic myocardium of eight patients with severe ischaemic heart disease as guided by electromechanical mapping with a percutaneous catheter procedure. After 3 months of follow-up, there was improvement in symptoms, myocardial perfusion, and function at the ischaemic region on MRI. Future randomised, controlled studies are required to validate this initial encouraging result.
dc.description.natureLink_to_subscribed_fulltext
dc.identifier.citationLancet, 2003, v. 361 n. 9351, p. 47-49 [How to Cite?]
DOI: http://dx.doi.org/10.1016/S0140-6736(03)12111-3
dc.identifier.doihttp://dx.doi.org/10.1016/S0140-6736(03)12111-3
dc.identifier.epage49
dc.identifier.issn0140-6736
2011 Impact Factor: 38.278
2011 SCImago Journal Rankings: 1.486
dc.identifier.issue9351
dc.identifier.pmid12517468
dc.identifier.scopuseid_2-s2.0-0037417506
dc.identifier.spage47
dc.identifier.urihttp://hdl.handle.net/10722/162681
dc.identifier.volume361
dc.languageeng
dc.publisherThe Lancet Publishing Group. The Journal's web site is located at http://www.elsevier.com/locate/lancet
dc.publisher.placeUnited Kingdom
dc.relation.ispartofLancet
dc.relation.referencesReferences in Scopus
dc.subject.meshAged
dc.subject.meshBone Marrow Transplantation - Methods
dc.subject.meshFeasibility Studies
dc.subject.meshFemale
dc.subject.meshFlow Cytometry
dc.subject.meshHumans
dc.subject.meshMale
dc.subject.meshMiddle Aged
dc.subject.meshMyocardial Ischemia - Therapy
dc.subject.meshNeovascularization, Physiologic
dc.subject.meshProspective Studies
dc.subject.meshTomography, Emission-Computed, Single-Photon
dc.subject.meshTreatment Outcome
dc.titleAngiogenesis in ischaemic myocardium by intramyocardial autologous bone marrow mononuclear cell implantation
dc.typeArticle
Author Affiliations
  1. The University of Hong Kong
  2. Hong Kong Sanatorium and Hospital