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Article: Angiogenesis in ischaemic myocardium by intramyocardial autologous bone marrow mononuclear cell implantation
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TitleAngiogenesis in ischaemic myocardium by intramyocardial autologous bone marrow mononuclear cell implantation
 
AuthorsTse, HF1
Kwong, YL1
Chan, JKF2
Lo, G2
Ho, CL2
Lau, CP1
 
Issue Date2003
 
PublisherThe Lancet Publishing Group. The Journal's web site is located at http://www.elsevier.com/locate/lancet
 
CitationLancet, 2003, v. 361 n. 9351, p. 47-49 [How to Cite?]
DOI: http://dx.doi.org/10.1016/S0140-6736(03)12111-3
 
AbstractResults of experimental studies have shown that intramyocardial implantation of bone marrow cells induces neovascularisation and improves heart function after myocardial infarction. Our aim was to test this notion in people. We implanted autologous mononuclear bone marrow cells into the ischaemic myocardium of eight patients with severe ischaemic heart disease as guided by electromechanical mapping with a percutaneous catheter procedure. After 3 months of follow-up, there was improvement in symptoms, myocardial perfusion, and function at the ischaemic region on MRI. Future randomised, controlled studies are required to validate this initial encouraging result.
 
ISSN0140-6736
2013 Impact Factor: 39.207
 
DOIhttp://dx.doi.org/10.1016/S0140-6736(03)12111-3
 
ReferencesReferences in Scopus
 
DC FieldValue
dc.contributor.authorTse, HF
 
dc.contributor.authorKwong, YL
 
dc.contributor.authorChan, JKF
 
dc.contributor.authorLo, G
 
dc.contributor.authorHo, CL
 
dc.contributor.authorLau, CP
 
dc.date.accessioned2012-09-05T05:22:17Z
 
dc.date.available2012-09-05T05:22:17Z
 
dc.date.issued2003
 
dc.description.abstractResults of experimental studies have shown that intramyocardial implantation of bone marrow cells induces neovascularisation and improves heart function after myocardial infarction. Our aim was to test this notion in people. We implanted autologous mononuclear bone marrow cells into the ischaemic myocardium of eight patients with severe ischaemic heart disease as guided by electromechanical mapping with a percutaneous catheter procedure. After 3 months of follow-up, there was improvement in symptoms, myocardial perfusion, and function at the ischaemic region on MRI. Future randomised, controlled studies are required to validate this initial encouraging result.
 
dc.description.naturelink_to_subscribed_fulltext
 
dc.identifier.citationLancet, 2003, v. 361 n. 9351, p. 47-49 [How to Cite?]
DOI: http://dx.doi.org/10.1016/S0140-6736(03)12111-3
 
dc.identifier.doihttp://dx.doi.org/10.1016/S0140-6736(03)12111-3
 
dc.identifier.epage49
 
dc.identifier.hkuros81898
 
dc.identifier.hkuros87916
 
dc.identifier.issn0140-6736
2013 Impact Factor: 39.207
 
dc.identifier.issue9351
 
dc.identifier.pmid12517468
 
dc.identifier.scopuseid_2-s2.0-0037417506
 
dc.identifier.spage47
 
dc.identifier.urihttp://hdl.handle.net/10722/162681
 
dc.identifier.volume361
 
dc.languageeng
 
dc.publisherThe Lancet Publishing Group. The Journal's web site is located at http://www.elsevier.com/locate/lancet
 
dc.publisher.placeUnited Kingdom
 
dc.relation.ispartofLancet
 
dc.relation.referencesReferences in Scopus
 
dc.subject.meshAged
 
dc.subject.meshBone Marrow Transplantation - Methods
 
dc.subject.meshFeasibility Studies
 
dc.subject.meshFemale
 
dc.subject.meshFlow Cytometry
 
dc.subject.meshHumans
 
dc.subject.meshMale
 
dc.subject.meshMiddle Aged
 
dc.subject.meshMyocardial Ischemia - Therapy
 
dc.subject.meshNeovascularization, Physiologic
 
dc.subject.meshProspective Studies
 
dc.subject.meshTomography, Emission-Computed, Single-Photon
 
dc.subject.meshTreatment Outcome
 
dc.titleAngiogenesis in ischaemic myocardium by intramyocardial autologous bone marrow mononuclear cell implantation
 
dc.typeArticle
 
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Author Affiliations
  1. The University of Hong Kong
  2. Hong Kong Sanatorium and Hospital