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Article: A rapid-release 50-mg tablet-based 13C-urea breath test for the diagnosis of Helicobacter pylori infection

TitleA rapid-release 50-mg tablet-based 13C-urea breath test for the diagnosis of Helicobacter pylori infection
Authors
Issue Date2003
PublisherBlackwell Publishing Ltd. The Journal's web site is located at http://www.blackwellpublishing.com/journals/APT
Citation
Alimentary Pharmacology And Therapeutics, 2003, v. 17 n. 2, p. 253-257 How to Cite?
AbstractBackground: Recently, a rapid-release 100-mg 13C-urea tablet with citrate supplement (Diabact UBT) showed excellent performance in a European population. Aim: To investigate the accuracy of a 50-mg tablet-based 13C-urea breath test protocol. Methods: Consecutive dyspeptic patients referred for upper endoscopy were recruited. 13C-Urea breath test was performed using a 50-mg 13C-urea tablet (Diabact UBT) and compared with the gold standard (rapid urease test and histology). Baseline, 10-min. 20-min and 30-min breath samples were collected in all cases. The cut-off values at each measurement interval were determined by three standard deviations above the mean excess δ 13CO 2 excretion of Helicobacter pylorinegative patients. Results: Two hundred patients (150 before therapy and 50 after therapy) were available for analysis, with a mean age of 48.4 years, and 99 patients (50%) were H. pylori positive. The sensitivity and specificity of the 50-mg tablet-based 13C-urea breath test at 10 min. 20 min and 30 min were 100% and 98%, 100% and 100%, and 100% and 98%, respectively. Conclusion: A 20-min. 50-mg tablet-based 13C-urea breath test (Diabact UBT) protocol is highly accurate for the diagnosis of H. pylori infection.
Persistent Identifierhttp://hdl.handle.net/10722/162672
ISSN
2015 Impact Factor: 6.32
2015 SCImago Journal Rankings: 2.833
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorWong, WMen_HK
dc.contributor.authorLam, SKen_HK
dc.contributor.authorLai, KCen_HK
dc.contributor.authorChu, KMen_HK
dc.contributor.authorXia, HHXen_HK
dc.contributor.authorWong, KWen_HK
dc.contributor.authorCheung, KLen_HK
dc.contributor.authorLin, SKen_HK
dc.contributor.authorWong, BCYen_HK
dc.date.accessioned2012-09-05T05:22:13Z-
dc.date.available2012-09-05T05:22:13Z-
dc.date.issued2003en_HK
dc.identifier.citationAlimentary Pharmacology And Therapeutics, 2003, v. 17 n. 2, p. 253-257en_HK
dc.identifier.issn0269-2813en_HK
dc.identifier.urihttp://hdl.handle.net/10722/162672-
dc.description.abstractBackground: Recently, a rapid-release 100-mg 13C-urea tablet with citrate supplement (Diabact UBT) showed excellent performance in a European population. Aim: To investigate the accuracy of a 50-mg tablet-based 13C-urea breath test protocol. Methods: Consecutive dyspeptic patients referred for upper endoscopy were recruited. 13C-Urea breath test was performed using a 50-mg 13C-urea tablet (Diabact UBT) and compared with the gold standard (rapid urease test and histology). Baseline, 10-min. 20-min and 30-min breath samples were collected in all cases. The cut-off values at each measurement interval were determined by three standard deviations above the mean excess δ 13CO 2 excretion of Helicobacter pylorinegative patients. Results: Two hundred patients (150 before therapy and 50 after therapy) were available for analysis, with a mean age of 48.4 years, and 99 patients (50%) were H. pylori positive. The sensitivity and specificity of the 50-mg tablet-based 13C-urea breath test at 10 min. 20 min and 30 min were 100% and 98%, 100% and 100%, and 100% and 98%, respectively. Conclusion: A 20-min. 50-mg tablet-based 13C-urea breath test (Diabact UBT) protocol is highly accurate for the diagnosis of H. pylori infection.en_HK
dc.languageengen_US
dc.publisherBlackwell Publishing Ltd. The Journal's web site is located at http://www.blackwellpublishing.com/journals/APTen_HK
dc.relation.ispartofAlimentary Pharmacology and Therapeuticsen_HK
dc.subject.meshAdolescenten_US
dc.subject.meshAdulten_US
dc.subject.meshAgeden_US
dc.subject.meshAged, 80 And Overen_US
dc.subject.meshBreath Testsen_US
dc.subject.meshCarbon Isotopes - Diagnostic Useen_US
dc.subject.meshCitric Acid - Administration & Dosageen_US
dc.subject.meshDrug Combinationsen_US
dc.subject.meshDyspepsia - Microbiologyen_US
dc.subject.meshFemaleen_US
dc.subject.meshHelicobacter Infections - Diagnosisen_US
dc.subject.meshHelicobacter Pylorien_US
dc.subject.meshHumansen_US
dc.subject.meshMaleen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshSensitivity And Specificityen_US
dc.subject.meshTabletsen_US
dc.subject.meshUrea - Administration & Dosage - Analysisen_US
dc.titleA rapid-release 50-mg tablet-based 13C-urea breath test for the diagnosis of Helicobacter pylori infectionen_HK
dc.typeArticleen_HK
dc.identifier.emailChu, KM: chukm@hkucc.hku.hken_HK
dc.identifier.emailWong, BCY: bcywong@hku.hken_HK
dc.identifier.authorityChu, KM=rp00435en_HK
dc.identifier.authorityWong, BCY=rp00429en_HK
dc.description.naturelink_to_OA_fulltexten_US
dc.identifier.doi10.1046/j.1365-2036.2003.01417.xen_HK
dc.identifier.pmid12534410-
dc.identifier.scopuseid_2-s2.0-0037312613en_HK
dc.identifier.hkuros75758-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0037312613&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume17en_HK
dc.identifier.issue2en_HK
dc.identifier.spage253en_HK
dc.identifier.epage257en_HK
dc.identifier.isiWOS:000180480900010-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridWong, WM=7403972413en_HK
dc.identifier.scopusauthoridLam, SK=7402279473en_HK
dc.identifier.scopusauthoridLai, KC=7402135595en_HK
dc.identifier.scopusauthoridChu, KM=7402453538en_HK
dc.identifier.scopusauthoridXia, HHX=8757161400en_HK
dc.identifier.scopusauthoridWong, KW=35118458300en_HK
dc.identifier.scopusauthoridCheung, KL=7402406543en_HK
dc.identifier.scopusauthoridLin, SK=7407154296en_HK
dc.identifier.scopusauthoridWong, BCY=7402023340en_HK

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