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Article: Anti-thymocyte globulin treatment of marrow aplasia associated with paroxysmal nocturnal haemoglobinuria (PNH) resulted in haematological improvement due to an expansion of the PNH clone
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TitleAnti-thymocyte globulin treatment of marrow aplasia associated with paroxysmal nocturnal haemoglobinuria (PNH) resulted in haematological improvement due to an expansion of the PNH clone
 
AuthorsCheung, WC2
Lam, CCK2
Kwong, YL2 1
 
Issue Date2003
 
PublisherBlackwell Publishing Ltd. The Journal's web site is located at http://www.blackwellpublishing.com/journals/BJH
 
CitationBritish Journal Of Haematology, 2003, v. 120 n. 2, p. 325-328 [How to Cite?]
DOI: http://dx.doi.org/10.1046/j.1365-2141.2003.04046.x
 
AbstractA patient with aplastic anaemia developed paroxysmal nocturnal haemoglobinuria (PNH) 4 years after diagnosis, with an ensuing haematopoietic improvement. The PNH clone subsequently declined, leading to pancytopenia again. Anti-thymocyte globulin had to be administered 14 years later, which resulted in haematopoietic improvement once more. Flow cytometric analysis showed that this was attributable to expansion of the PNH clone, owing probably to alleviation of its suppression by immune-mediated mechanisms. PIG-A gene analysis showed that the same PNH clone had waned and waxed in the clinical course. Our results suggest that the PNH clone might rarely be an immune target as well.
 
ISSN0007-1048
2013 Impact Factor: 4.959
 
DOIhttp://dx.doi.org/10.1046/j.1365-2141.2003.04046.x
 
ReferencesReferences in Scopus
 
DC FieldValue
dc.contributor.authorCheung, WC
 
dc.contributor.authorLam, CCK
 
dc.contributor.authorKwong, YL
 
dc.date.accessioned2012-09-05T05:22:12Z
 
dc.date.available2012-09-05T05:22:12Z
 
dc.date.issued2003
 
dc.description.abstractA patient with aplastic anaemia developed paroxysmal nocturnal haemoglobinuria (PNH) 4 years after diagnosis, with an ensuing haematopoietic improvement. The PNH clone subsequently declined, leading to pancytopenia again. Anti-thymocyte globulin had to be administered 14 years later, which resulted in haematopoietic improvement once more. Flow cytometric analysis showed that this was attributable to expansion of the PNH clone, owing probably to alleviation of its suppression by immune-mediated mechanisms. PIG-A gene analysis showed that the same PNH clone had waned and waxed in the clinical course. Our results suggest that the PNH clone might rarely be an immune target as well.
 
dc.description.naturelink_to_OA_fulltext
 
dc.identifier.citationBritish Journal Of Haematology, 2003, v. 120 n. 2, p. 325-328 [How to Cite?]
DOI: http://dx.doi.org/10.1046/j.1365-2141.2003.04046.x
 
dc.identifier.doihttp://dx.doi.org/10.1046/j.1365-2141.2003.04046.x
 
dc.identifier.epage328
 
dc.identifier.hkuros77689
 
dc.identifier.issn0007-1048
2013 Impact Factor: 4.959
 
dc.identifier.issue2
 
dc.identifier.pmid12542494
 
dc.identifier.scopuseid_2-s2.0-0037276180
 
dc.identifier.spage325
 
dc.identifier.urihttp://hdl.handle.net/10722/162668
 
dc.identifier.volume120
 
dc.languageeng
 
dc.publisherBlackwell Publishing Ltd. The Journal's web site is located at http://www.blackwellpublishing.com/journals/BJH
 
dc.publisher.placeUnited Kingdom
 
dc.relation.ispartofBritish Journal of Haematology
 
dc.relation.referencesReferences in Scopus
 
dc.rightsBritish Journal of Haematology. Copyright © Blackwell Publishing Ltd.
 
dc.subject.meshAdult
 
dc.subject.meshAnemia, Aplastic - Complications - Therapy
 
dc.subject.meshAntilymphocyte Serum - Therapeutic Use
 
dc.subject.meshBase Sequence
 
dc.subject.meshCell Count
 
dc.subject.meshClone Cells
 
dc.subject.meshFlow Cytometry
 
dc.subject.meshFrameshift Mutation
 
dc.subject.meshGene Deletion
 
dc.subject.meshHemoglobinuria, Paroxysmal - Blood - Complications - Genetics
 
dc.subject.meshHumans
 
dc.subject.meshMale
 
dc.subject.meshMembrane Proteins - Genetics - Metabolism
 
dc.subject.meshMolecular Sequence Data
 
dc.subject.meshSequence Analysis, Dna
 
dc.subject.meshTime Factors
 
dc.titleAnti-thymocyte globulin treatment of marrow aplasia associated with paroxysmal nocturnal haemoglobinuria (PNH) resulted in haematological improvement due to an expansion of the PNH clone
 
dc.typeArticle
 
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Author Affiliations
  1. The University of Hong Kong
  2. Queen Mary Hospital Hong Kong