Article: Anti-thymocyte globulin treatment of marrow aplasia associated with paroxysmal nocturnal haemoglobinuria (PNH) resulted in haematological improvement due to an expansion of the PNH clone

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TitleAnti-thymocyte globulin treatment of marrow aplasia associated with paroxysmal nocturnal haemoglobinuria (PNH) resulted in haematological improvement due to an expansion of the PNH clone
AuthorsCheung, WC2
Lam, CCK2
Kwong, YL1 2
Issue Date2003
PublisherBlackwell Publishing Ltd. The Journal's web site is located at http://www.blackwellpublishing.com/journals/BJH
CitationBritish Journal Of Haematology, 2003, v. 120 n. 2, p. 325-328 [How to Cite?]
DOI: http://dx.doi.org/10.1046/j.1365-2141.2003.04046.x
AbstractA patient with aplastic anaemia developed paroxysmal nocturnal haemoglobinuria (PNH) 4 years after diagnosis, with an ensuing haematopoietic improvement. The PNH clone subsequently declined, leading to pancytopenia again. Anti-thymocyte globulin had to be administered 14 years later, which resulted in haematopoietic improvement once more. Flow cytometric analysis showed that this was attributable to expansion of the PNH clone, owing probably to alleviation of its suppression by immune-mediated mechanisms. PIG-A gene analysis showed that the same PNH clone had waned and waxed in the clinical course. Our results suggest that the PNH clone might rarely be an immune target as well.
ISSN0007-1048
2011 Impact Factor: 4.941
2011 SCImago Journal Rankings: 0.586
DOIhttp://dx.doi.org/10.1046/j.1365-2141.2003.04046.x
ReferencesReferences in Scopus
DC Field
Value
dc.contributor.authorCheung, WC
dc.contributor.authorLam, CCK
dc.contributor.authorKwong, YL
dc.date.accessioned2012-09-05T05:22:12Z
dc.date.available2012-09-05T05:22:12Z
dc.date.issued2003
dc.description.abstractA patient with aplastic anaemia developed paroxysmal nocturnal haemoglobinuria (PNH) 4 years after diagnosis, with an ensuing haematopoietic improvement. The PNH clone subsequently declined, leading to pancytopenia again. Anti-thymocyte globulin had to be administered 14 years later, which resulted in haematopoietic improvement once more. Flow cytometric analysis showed that this was attributable to expansion of the PNH clone, owing probably to alleviation of its suppression by immune-mediated mechanisms. PIG-A gene analysis showed that the same PNH clone had waned and waxed in the clinical course. Our results suggest that the PNH clone might rarely be an immune target as well.
dc.description.natureLink_to_subscribed_fulltext
dc.identifier.citationBritish Journal Of Haematology, 2003, v. 120 n. 2, p. 325-328 [How to Cite?]
DOI: http://dx.doi.org/10.1046/j.1365-2141.2003.04046.x
dc.identifier.doihttp://dx.doi.org/10.1046/j.1365-2141.2003.04046.x
dc.identifier.epage328
dc.identifier.issn0007-1048
2011 Impact Factor: 4.941
2011 SCImago Journal Rankings: 0.586
dc.identifier.issue2
dc.identifier.pmid12542494
dc.identifier.scopuseid_2-s2.0-0037276180
dc.identifier.spage325
dc.identifier.urihttp://hdl.handle.net/10722/162668
dc.identifier.volume120
dc.languageeng
dc.publisherBlackwell Publishing Ltd. The Journal's web site is located at http://www.blackwellpublishing.com/journals/BJH
dc.publisher.placeUnited Kingdom
dc.relation.ispartofBritish Journal of Haematology
dc.relation.referencesReferences in Scopus
dc.subject.meshAdult
dc.subject.meshAnemia, Aplastic - Complications - Therapy
dc.subject.meshAntilymphocyte Serum - Therapeutic Use
dc.subject.meshBase Sequence
dc.subject.meshCell Count
dc.subject.meshClone Cells
dc.subject.meshFlow Cytometry
dc.subject.meshFrameshift Mutation
dc.subject.meshGene Deletion
dc.subject.meshHemoglobinuria, Paroxysmal - Blood - Complications - Genetics
dc.subject.meshHumans
dc.subject.meshMale
dc.subject.meshMembrane Proteins - Genetics - Metabolism
dc.subject.meshMolecular Sequence Data
dc.subject.meshSequence Analysis, Dna
dc.subject.meshTime Factors
dc.titleAnti-thymocyte globulin treatment of marrow aplasia associated with paroxysmal nocturnal haemoglobinuria (PNH) resulted in haematological improvement due to an expansion of the PNH clone
dc.typeArticle
Author Affiliations
  1. The University of Hong Kong
  2. Queen Mary Hospital Hong Kong