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Article: Anti-thymocyte globulin treatment of marrow aplasia associated with paroxysmal nocturnal haemoglobinuria (PNH) resulted in haematological improvement due to an expansion of the PNH clone

TitleAnti-thymocyte globulin treatment of marrow aplasia associated with paroxysmal nocturnal haemoglobinuria (PNH) resulted in haematological improvement due to an expansion of the PNH clone
Authors
Issue Date2003
PublisherBlackwell Publishing Ltd. The Journal's web site is located at http://www.blackwellpublishing.com/journals/BJH
Citation
British Journal Of Haematology, 2003, v. 120 n. 2, p. 325-328 How to Cite?
Abstract
A patient with aplastic anaemia developed paroxysmal nocturnal haemoglobinuria (PNH) 4 years after diagnosis, with an ensuing haematopoietic improvement. The PNH clone subsequently declined, leading to pancytopenia again. Anti-thymocyte globulin had to be administered 14 years later, which resulted in haematopoietic improvement once more. Flow cytometric analysis showed that this was attributable to expansion of the PNH clone, owing probably to alleviation of its suppression by immune-mediated mechanisms. PIG-A gene analysis showed that the same PNH clone had waned and waxed in the clinical course. Our results suggest that the PNH clone might rarely be an immune target as well.
Persistent Identifierhttp://hdl.handle.net/10722/162668
ISSN
2013 Impact Factor: 4.959
ISI Accession Number ID
References

 

Author Affiliations
  1. The University of Hong Kong
  2. Queen Mary Hospital Hong Kong
DC FieldValueLanguage
dc.contributor.authorCheung, WCen_US
dc.contributor.authorLam, CCKen_US
dc.contributor.authorKwong, YLen_US
dc.date.accessioned2012-09-05T05:22:12Z-
dc.date.available2012-09-05T05:22:12Z-
dc.date.issued2003en_US
dc.identifier.citationBritish Journal Of Haematology, 2003, v. 120 n. 2, p. 325-328en_US
dc.identifier.issn0007-1048en_US
dc.identifier.urihttp://hdl.handle.net/10722/162668-
dc.description.abstractA patient with aplastic anaemia developed paroxysmal nocturnal haemoglobinuria (PNH) 4 years after diagnosis, with an ensuing haematopoietic improvement. The PNH clone subsequently declined, leading to pancytopenia again. Anti-thymocyte globulin had to be administered 14 years later, which resulted in haematopoietic improvement once more. Flow cytometric analysis showed that this was attributable to expansion of the PNH clone, owing probably to alleviation of its suppression by immune-mediated mechanisms. PIG-A gene analysis showed that the same PNH clone had waned and waxed in the clinical course. Our results suggest that the PNH clone might rarely be an immune target as well.en_US
dc.languageengen_US
dc.publisherBlackwell Publishing Ltd. The Journal's web site is located at http://www.blackwellpublishing.com/journals/BJHen_US
dc.relation.ispartofBritish Journal of Haematologyen_US
dc.rightsBritish Journal of Haematology. Copyright © Blackwell Publishing Ltd.-
dc.subject.meshAdulten_US
dc.subject.meshAnemia, Aplastic - Complications - Therapyen_US
dc.subject.meshAntilymphocyte Serum - Therapeutic Useen_US
dc.subject.meshBase Sequenceen_US
dc.subject.meshCell Counten_US
dc.subject.meshClone Cellsen_US
dc.subject.meshFlow Cytometryen_US
dc.subject.meshFrameshift Mutationen_US
dc.subject.meshGene Deletionen_US
dc.subject.meshHemoglobinuria, Paroxysmal - Blood - Complications - Geneticsen_US
dc.subject.meshHumansen_US
dc.subject.meshMaleen_US
dc.subject.meshMembrane Proteins - Genetics - Metabolismen_US
dc.subject.meshMolecular Sequence Dataen_US
dc.subject.meshSequence Analysis, Dnaen_US
dc.subject.meshTime Factorsen_US
dc.titleAnti-thymocyte globulin treatment of marrow aplasia associated with paroxysmal nocturnal haemoglobinuria (PNH) resulted in haematological improvement due to an expansion of the PNH cloneen_US
dc.typeArticleen_US
dc.identifier.emailKwong, YL:ylkwong@hku.hken_US
dc.identifier.authorityKwong, YL=rp00358en_US
dc.description.naturelink_to_OA_fulltexten_US
dc.identifier.doi10.1046/j.1365-2141.2003.04046.xen_US
dc.identifier.pmid12542494en_US
dc.identifier.scopuseid_2-s2.0-0037276180en_US
dc.identifier.hkuros77689-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0037276180&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume120en_US
dc.identifier.issue2en_US
dc.identifier.spage325en_US
dc.identifier.epage328en_US
dc.identifier.isiWOS:000180598900023-
dc.publisher.placeUnited Kingdomen_US
dc.identifier.scopusauthoridCheung, WC=36934683800en_US
dc.identifier.scopusauthoridLam, CCK=16947291300en_US
dc.identifier.scopusauthoridKwong, YL=7102818954en_US

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