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Article: Regulation of kinin receptors in airway epithelial cells by inflammatory cytokines and dexamethasone

TitleRegulation of kinin receptors in airway epithelial cells by inflammatory cytokines and dexamethasone
Authors
Issue Date2002
PublisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/ejphar
Citation
European Journal Of Pharmacology, 2002, v. 441 n. 3, p. 193-202 How to Cite?
AbstractThe two kinin receptors, B1 and B2, are upregulated in inflammation and may play a role in diseases such as asthma. In pulmonary A549 cells, TNF-α or interleukin-1β dramatically increased bradykinin B1 and B2 receptor mRNA expression and this response was prevented by dexamethasone. In primary human bronchial epithelial cells, bradykinin B1 receptor mRNA expression showed a similar trend, whereas bradykinin B2 receptor showed almost constitutive expression. Radioligand-binding studies revealed significant increases in bradykinin B2 receptor protein expression following both interleukin-1β and TNF-α treatment of A549 cells; however, no evidence was found for bradykinin B1 receptor. Functionally, the bradykinin B2 receptor ligand, bradykinin, but not the B1 ligand, des-Arg10-kallidin, produced a marked increase in prostaglandin E2 release when administered following interleukin-1β treatment. Arachidonic acid release in response to bradykinin was markedly enhanced by prior incubation with interleukin-1β and this was prevented by the prior addition of dexamethasone. © 2002 Elsevier Science B.V. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/162661
ISSN
2015 Impact Factor: 2.73
2015 SCImago Journal Rankings: 1.115
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorNewton, Ren_US
dc.contributor.authorEddleston, Jen_US
dc.contributor.authorHaddad, EBen_US
dc.contributor.authorHawisa, Sen_US
dc.contributor.authorMak, Jen_US
dc.contributor.authorLim, Sen_US
dc.contributor.authorFox, AJen_US
dc.contributor.authorDonnelly, LEen_US
dc.contributor.authorChung, KFen_US
dc.date.accessioned2012-09-05T05:22:09Z-
dc.date.available2012-09-05T05:22:09Z-
dc.date.issued2002en_US
dc.identifier.citationEuropean Journal Of Pharmacology, 2002, v. 441 n. 3, p. 193-202en_US
dc.identifier.issn0014-2999en_US
dc.identifier.urihttp://hdl.handle.net/10722/162661-
dc.description.abstractThe two kinin receptors, B1 and B2, are upregulated in inflammation and may play a role in diseases such as asthma. In pulmonary A549 cells, TNF-α or interleukin-1β dramatically increased bradykinin B1 and B2 receptor mRNA expression and this response was prevented by dexamethasone. In primary human bronchial epithelial cells, bradykinin B1 receptor mRNA expression showed a similar trend, whereas bradykinin B2 receptor showed almost constitutive expression. Radioligand-binding studies revealed significant increases in bradykinin B2 receptor protein expression following both interleukin-1β and TNF-α treatment of A549 cells; however, no evidence was found for bradykinin B1 receptor. Functionally, the bradykinin B2 receptor ligand, bradykinin, but not the B1 ligand, des-Arg10-kallidin, produced a marked increase in prostaglandin E2 release when administered following interleukin-1β treatment. Arachidonic acid release in response to bradykinin was markedly enhanced by prior incubation with interleukin-1β and this was prevented by the prior addition of dexamethasone. © 2002 Elsevier Science B.V. All rights reserved.en_US
dc.languageengen_US
dc.publisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/ejpharen_US
dc.relation.ispartofEuropean Journal of Pharmacologyen_US
dc.subject.meshBronchi - Cytology - Drug Effects - Metabolismen_US
dc.subject.meshCells, Cultureden_US
dc.subject.meshCytokines - Pharmacology - Physiologyen_US
dc.subject.meshDexamethasone - Pharmacologyen_US
dc.subject.meshDinoprostone - Biosynthesis - Secretionen_US
dc.subject.meshDose-Response Relationship, Drugen_US
dc.subject.meshEpithelial Cells - Cytology - Drug Effects - Metabolismen_US
dc.subject.meshHumansen_US
dc.subject.meshInflammation - Metabolismen_US
dc.subject.meshRna, Messenger - Biosynthesisen_US
dc.subject.meshReceptor, Bradykinin B1en_US
dc.subject.meshReceptor, Bradykinin B2en_US
dc.subject.meshReceptors, Bradykinin - Biosynthesisen_US
dc.titleRegulation of kinin receptors in airway epithelial cells by inflammatory cytokines and dexamethasoneen_US
dc.typeArticleen_US
dc.identifier.emailMak, J:judymak@hku.hken_US
dc.identifier.authorityMak, J=rp00352en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1016/S0014-2999(01)01624-7en_US
dc.identifier.pmid12063092en_US
dc.identifier.scopuseid_2-s2.0-0037177365en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0037177365&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume441en_US
dc.identifier.issue3en_US
dc.identifier.spage193en_US
dc.identifier.epage202en_US
dc.identifier.isiWOS:000176636200010-
dc.publisher.placeNetherlandsen_US
dc.identifier.scopusauthoridNewton, R=7401831692en_US
dc.identifier.scopusauthoridEddleston, J=36004501900en_US
dc.identifier.scopusauthoridHaddad, EB=7102803008en_US
dc.identifier.scopusauthoridHawisa, S=6507108661en_US
dc.identifier.scopusauthoridMak, J=7103323094en_US
dc.identifier.scopusauthoridLim, S=7404081530en_US
dc.identifier.scopusauthoridFox, AJ=7402906898en_US
dc.identifier.scopusauthoridDonnelly, LE=7102000743en_US
dc.identifier.scopusauthoridChung, KF=35403525000en_US

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