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Article: Two cases of therapy-related acute promyelocytic leukemia (t-APL) after mantle cell lymphoma and gestational trophoblastic disease

TitleTwo cases of therapy-related acute promyelocytic leukemia (t-APL) after mantle cell lymphoma and gestational trophoblastic disease
Authors
KeywordsArsenic
Gestational trophoblastic disease
Mantle cell lymphoma
Secondary APL
Issue Date2002
PublisherSpringer Verlag. The Journal's web site is located at http://link.springer.de/link/service/journals/00277/index.htm
Citation
Annals Of Hematology, 2002, v. 81 n. 11, p. 659-661 How to Cite?
AbstractWe report two cases of secondary acute promyelocytic leukemia (APL). One patient presented with concurrent APL and missed abortion 1 year after etoposide-based chemotherapy for gestational trophoblastic disease. A prolonged complete remission was achieved with standard chemotherapy. An elderly man developed APL 1 year after alkylator-based chemotherapy for mantle cell lymphoma (MCL). A complete clinical and molecular remission was obtained with chemotherapy and all-trans retinoic acid, followed by arsenic consolidation. Concomitant molecular relapse of APL and MCL clones was detected at 1 year, both of which responded to oral arsenic therapy. High-dose epipodophyllin is a dose risk for secondary APL, but alkylating agents may also be implicated. For patients with a history of active malignancy and heavy previous chemotherapy exposure, the use of nontoxic arsenic therapy appeared to be effective and prudent.
Persistent Identifierhttp://hdl.handle.net/10722/162647
ISSN
2015 Impact Factor: 3.022
2015 SCImago Journal Rankings: 1.117
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorAu, WYen_HK
dc.contributor.authorMa, SKen_HK
dc.contributor.authorChung, LPen_HK
dc.contributor.authorChim, CSen_HK
dc.contributor.authorKwong, YLen_HK
dc.date.accessioned2012-09-05T05:22:02Z-
dc.date.available2012-09-05T05:22:02Z-
dc.date.issued2002en_HK
dc.identifier.citationAnnals Of Hematology, 2002, v. 81 n. 11, p. 659-661en_HK
dc.identifier.issn0939-5555en_HK
dc.identifier.urihttp://hdl.handle.net/10722/162647-
dc.description.abstractWe report two cases of secondary acute promyelocytic leukemia (APL). One patient presented with concurrent APL and missed abortion 1 year after etoposide-based chemotherapy for gestational trophoblastic disease. A prolonged complete remission was achieved with standard chemotherapy. An elderly man developed APL 1 year after alkylator-based chemotherapy for mantle cell lymphoma (MCL). A complete clinical and molecular remission was obtained with chemotherapy and all-trans retinoic acid, followed by arsenic consolidation. Concomitant molecular relapse of APL and MCL clones was detected at 1 year, both of which responded to oral arsenic therapy. High-dose epipodophyllin is a dose risk for secondary APL, but alkylating agents may also be implicated. For patients with a history of active malignancy and heavy previous chemotherapy exposure, the use of nontoxic arsenic therapy appeared to be effective and prudent.en_HK
dc.languageengen_US
dc.publisherSpringer Verlag. The Journal's web site is located at http://link.springer.de/link/service/journals/00277/index.htmen_HK
dc.relation.ispartofAnnals of Hematologyen_HK
dc.subjectArsenicen_HK
dc.subjectGestational trophoblastic diseaseen_HK
dc.subjectMantle cell lymphomaen_HK
dc.subjectSecondary APLen_HK
dc.subject.meshAdulten_US
dc.subject.meshAgeden_US
dc.subject.meshAntineoplastic Agents, Alkylating - Adverse Effects - Therapeutic Useen_US
dc.subject.meshArsenicals - Therapeutic Useen_US
dc.subject.meshEtoposide - Adverse Effects - Therapeutic Useen_US
dc.subject.meshFemaleen_US
dc.subject.meshGestational Trophoblastic Disease - Drug Therapy - Pathologyen_US
dc.subject.meshHumansen_US
dc.subject.meshLeukemia, Promyelocytic, Acute - Chemically Induced - Drug Therapy - Etiologyen_US
dc.subject.meshLymphoma, Mantle-Cell - Drug Therapy - Pathologyen_US
dc.subject.meshMaleen_US
dc.subject.meshNeoplasms, Second Primary - Drug Therapy - Etiologyen_US
dc.subject.meshOxides - Therapeutic Useen_US
dc.subject.meshPregnancyen_US
dc.subject.meshTretinoin - Therapeutic Useen_US
dc.titleTwo cases of therapy-related acute promyelocytic leukemia (t-APL) after mantle cell lymphoma and gestational trophoblastic diseaseen_HK
dc.typeArticleen_HK
dc.identifier.emailChung, LP: lpchung@hkucc.hku.hken_HK
dc.identifier.emailKwong, YL: ylkwong@hku.hken_HK
dc.identifier.authorityChung, LP=rp00249en_HK
dc.identifier.authorityKwong, YL=rp00358en_HK
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1007/s00277-002-0552-6en_HK
dc.identifier.pmid12454706-
dc.identifier.scopuseid_2-s2.0-0036938435en_HK
dc.identifier.hkuros77876-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0036938435&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume81en_HK
dc.identifier.issue11en_HK
dc.identifier.spage659en_HK
dc.identifier.epage661en_HK
dc.identifier.isiWOS:000179992200010-
dc.publisher.placeGermanyen_HK
dc.identifier.scopusauthoridAu, WY=7202383089en_HK
dc.identifier.scopusauthoridMa, SK=37020910400en_HK
dc.identifier.scopusauthoridChung, LP=24315879100en_HK
dc.identifier.scopusauthoridShim, CS=7103280886en_HK
dc.identifier.scopusauthoridKwong, YL=7102818954en_HK

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