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Article: Relationship between Helicobacter pylori babA2 status with gastric epithelial cell turnover and premalignant gastric lesions

TitleRelationship between Helicobacter pylori babA2 status with gastric epithelial cell turnover and premalignant gastric lesions
Authors
Issue Date2002
PublisherBMJ Publishing Group. The Journal's web site is located at http://gut.bmjjournals.com/
Citation
Gut, 2002, v. 51 n. 4, p. 480-484 How to Cite?
AbstractBackground: Helicobacter pylori blood group antigen binding adhesin (BabA) mediates bacterial adherence to human blood group antigens on gastric epithelium. Although strains harbouring babA2 were recently found to be associated with peptic ulcer and gastric cancer, the role of babA2 in cellular turnover, severity of gastritis, and premalignant changes is poorly understood. Aim: We correlated H pylori babA2, vacuolating toxin (vacA), and cytotoxin associated gene A (cagA) genotypes with the severity of gastric inflammation and epithelial cell turnover in a group of Chinese patients from an area with a high incidence of gastric cancer. Patients and methods: H pylori isolates were obtained from 104 Chinese patients who participated in a gastric cancer prevention programme. Genotype variants of babA2, vacA, and cagA were determined by polymerase chain reaction. Antrum and corpus histopathology was examined according to the updated Sydney classification. Apoptosis was scored by terminal uridine deoxynucleotidyl nick end labeling (TUNEL) and proliferation by Ki-67 immunostaining. Results: Of the 104 patients, 102 (98.1%) harboured cagA + strains and all had vacA s1 genotype. The babA2 + strains were found in 83 (79.8%) patients and were associated with higher lymphocytic infiltration (p = 0.028), presence of glandular atrophy (odds ratio (OR) 7.5, 95% confidence interval (CI) 2.3-24.3), and intestinal metaplasia (OR 7.4, 95% CI 2.2-25.3) in the antrum. Increased epithelial proliferation was also noted in individuals infected with babA2 + strains (p = 0.025). Strains harbouring cagA +/vacA s1 genotypes lacked this association in the absence of babA2. Conclusions: The presence of babA2 + H pylori strains alone or in combination with cagA + and vacA s1 was associated with the presence of preneoplastic gastric lesions.
Persistent Identifierhttp://hdl.handle.net/10722/162636
ISSN
2015 Impact Factor: 14.921
2015 SCImago Journal Rankings: 6.474
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorYu, Jen_US
dc.contributor.authorLeung, WKen_US
dc.contributor.authorGo, MYYen_US
dc.contributor.authorChan, MCWen_US
dc.contributor.authorTo, KFen_US
dc.contributor.authorNg, EKWen_US
dc.contributor.authorChan, FKLen_US
dc.contributor.authorLing, TKWen_US
dc.contributor.authorChung, SCSen_US
dc.contributor.authorSung, JJYen_US
dc.date.accessioned2012-09-05T05:21:56Z-
dc.date.available2012-09-05T05:21:56Z-
dc.date.issued2002en_US
dc.identifier.citationGut, 2002, v. 51 n. 4, p. 480-484en_US
dc.identifier.issn0017-5749en_US
dc.identifier.urihttp://hdl.handle.net/10722/162636-
dc.description.abstractBackground: Helicobacter pylori blood group antigen binding adhesin (BabA) mediates bacterial adherence to human blood group antigens on gastric epithelium. Although strains harbouring babA2 were recently found to be associated with peptic ulcer and gastric cancer, the role of babA2 in cellular turnover, severity of gastritis, and premalignant changes is poorly understood. Aim: We correlated H pylori babA2, vacuolating toxin (vacA), and cytotoxin associated gene A (cagA) genotypes with the severity of gastric inflammation and epithelial cell turnover in a group of Chinese patients from an area with a high incidence of gastric cancer. Patients and methods: H pylori isolates were obtained from 104 Chinese patients who participated in a gastric cancer prevention programme. Genotype variants of babA2, vacA, and cagA were determined by polymerase chain reaction. Antrum and corpus histopathology was examined according to the updated Sydney classification. Apoptosis was scored by terminal uridine deoxynucleotidyl nick end labeling (TUNEL) and proliferation by Ki-67 immunostaining. Results: Of the 104 patients, 102 (98.1%) harboured cagA + strains and all had vacA s1 genotype. The babA2 + strains were found in 83 (79.8%) patients and were associated with higher lymphocytic infiltration (p = 0.028), presence of glandular atrophy (odds ratio (OR) 7.5, 95% confidence interval (CI) 2.3-24.3), and intestinal metaplasia (OR 7.4, 95% CI 2.2-25.3) in the antrum. Increased epithelial proliferation was also noted in individuals infected with babA2 + strains (p = 0.025). Strains harbouring cagA +/vacA s1 genotypes lacked this association in the absence of babA2. Conclusions: The presence of babA2 + H pylori strains alone or in combination with cagA + and vacA s1 was associated with the presence of preneoplastic gastric lesions.en_US
dc.languageengen_US
dc.publisherBMJ Publishing Group. The Journal's web site is located at http://gut.bmjjournals.com/en_US
dc.relation.ispartofGuten_US
dc.subject.meshAdhesins, Bacterialen_US
dc.subject.meshAdulten_US
dc.subject.meshAgeden_US
dc.subject.meshAntigens, Bacterialen_US
dc.subject.meshApoptosisen_US
dc.subject.meshAtrophyen_US
dc.subject.meshBacterial Proteins - Geneticsen_US
dc.subject.meshCarrier Proteins - Geneticsen_US
dc.subject.meshCell Divisionen_US
dc.subject.meshCross-Sectional Studiesen_US
dc.subject.meshEpithelial Cells - Pathologyen_US
dc.subject.meshGastritis - Genetics - Pathologyen_US
dc.subject.meshGenotypeen_US
dc.subject.meshHelicobacter Infections - Geneticsen_US
dc.subject.meshHelicobacter Pylori - Geneticsen_US
dc.subject.meshHumansen_US
dc.subject.meshIntestinal Neoplasms - Secondaryen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshPrecancerous Conditions - Genetics - Pathologyen_US
dc.subject.meshStomach Neoplasms - Genetics - Pathologyen_US
dc.titleRelationship between Helicobacter pylori babA2 status with gastric epithelial cell turnover and premalignant gastric lesionsen_US
dc.typeArticleen_US
dc.identifier.emailLeung, WK:waikleung@hku.hken_US
dc.identifier.authorityLeung, WK=rp01479en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1136/gut.51.4.480en_US
dc.identifier.pmid12235067-
dc.identifier.scopuseid_2-s2.0-0036786868en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0036786868&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume51en_US
dc.identifier.issue4en_US
dc.identifier.spage480en_US
dc.identifier.epage484en_US
dc.identifier.isiWOS:000178243600008-
dc.publisher.placeUnited Kingdomen_US
dc.identifier.scopusauthoridYu, J=35351306800en_US
dc.identifier.scopusauthoridLeung, WK=7201504523en_US
dc.identifier.scopusauthoridGo, MYY=7101882939en_US
dc.identifier.scopusauthoridChan, MCW=36941299700en_US
dc.identifier.scopusauthoridTo, KF=7101911940en_US
dc.identifier.scopusauthoridNg, EKW=7201647539en_US
dc.identifier.scopusauthoridChan, FKL=7202586434en_US
dc.identifier.scopusauthoridLing, TKW=13310253900en_US
dc.identifier.scopusauthoridChung, SCS=19642462800en_US
dc.identifier.scopusauthoridSung, JJY=35405352400en_US

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