Article: Increased expression of survivin in gastric cancer patients and in first degree relatives

File Download

No File Attached
The HKU Scholars Hub has contact details for these author(s).
- Professor Leung, Wai Keung

Links for fulltext
(May Require Subscription)

Publisher Website: 10.1038/sj.bjc.6600421
Scopus: eid_2-s2.0-0036648414
PMID: 12085263

Supplementary

Citations:
- Scopus:
- Web of Science:
- PubMed Central:
Item Statistics (The Hub)
Appears in Collections:
- Medicine: Journal/Magazine Articles

Title	Increased expression of survivin in gastric cancer patients and in first degree relatives
Authors	Yu, J1 Leung, WK1 Ebert, MPA1 Ng, EKW1 Go, MYY1 Wang, HB1 Chung, SCS1 Malfertheiner, P1 Sung, JJY1
Issue Date	2002
Publisher	Nature Publishing Group. The Journal's web site is located at http://www.nature.com/bjc
Citation	British Journal Of Cancer, 2002, v. 87 n. 1, p. 91-97 [How to Cite?] DOI: http://dx.doi.org/10.1038/sj.bjc.6600421
Abstract	Survivin was recently described as an apoptosis inhibitor. Its pathogenic role in gastric cancer is largely unknown. Expression of survivin in gastric cancer and non-cancer first-degree relatives, and its association with apoptosis and cyclo-oxygenase-2 expression was investigated. Fifty gastric cancer, 30 non-cancer first-degree relatives, 20 normal controls and five gastric cancer cell lines were studied. Survivin and cyclo-oxygenase-2 were evaluated by reverse transcriptase-polymerase chain reaction, immunohistochemistry and Western blot. Survivin expression was absent from normal gastric mucosa. All five cancer cell lines and 34 out of 50 (68%) human gastric cancer tissues expressed survivin mRNA. Survivin expression was less frequent (22%; P<0.001) in adjacent non-tumour gastric tissues. Immunohistochemistry and Western blot obtained similar findings. Gastric cancers with survivin expression displayed significantly reduced apoptosis (P=0.02), and associated with cyclo-oxygenase-2 overexpression at both mRNA (P=0.001) and protein levels (P=0.041). Moreover, survivin mRNA was detected in the gastric mucosa of eight (27%) non-cancer relatives. Expression in non-cancer patients showed positive correlation with H. pylori infection (P=0.004). This demonstrates the frequent expression of survivin in gastric cancer and in first-degree relatives. Co-expression of survivin and cyclo-oxygenase-2 may suggest multiple pathways contributing to the inhibition of apoptosis in gastric cancer. © 2002 Cancer Research UK.
ISSN	0007-0920 2011 Impact Factor: 5.042 2011 SCImago Journal Rankings: 0.561
DOI	http://dx.doi.org/10.1038/sj.bjc.6600421
References	References in Scopus

DC Field	Value
dc.contributor.author	Yu, J
dc.contributor.author	Leung, WK
dc.contributor.author	Ebert, MPA
dc.contributor.author	Ng, EKW
dc.contributor.author	Go, MYY
dc.contributor.author	Wang, HB
dc.contributor.author	Chung, SCS
dc.contributor.author	Malfertheiner, P
dc.contributor.author	Sung, JJY
dc.date.accessioned	2012-09-05T05:21:48Z
dc.date.available	2012-09-05T05:21:48Z
dc.date.issued	2002
dc.description.abstract	Survivin was recently described as an apoptosis inhibitor. Its pathogenic role in gastric cancer is largely unknown. Expression of survivin in gastric cancer and non-cancer first-degree relatives, and its association with apoptosis and cyclo-oxygenase-2 expression was investigated. Fifty gastric cancer, 30 non-cancer first-degree relatives, 20 normal controls and five gastric cancer cell lines were studied. Survivin and cyclo-oxygenase-2 were evaluated by reverse transcriptase-polymerase chain reaction, immunohistochemistry and Western blot. Survivin expression was absent from normal gastric mucosa. All five cancer cell lines and 34 out of 50 (68%) human gastric cancer tissues expressed survivin mRNA. Survivin expression was less frequent (22%; P<0.001) in adjacent non-tumour gastric tissues. Immunohistochemistry and Western blot obtained similar findings. Gastric cancers with survivin expression displayed significantly reduced apoptosis (P=0.02), and associated with cyclo-oxygenase-2 overexpression at both mRNA (P=0.001) and protein levels (P=0.041). Moreover, survivin mRNA was detected in the gastric mucosa of eight (27%) non-cancer relatives. Expression in non-cancer patients showed positive correlation with H. pylori infection (P=0.004). This demonstrates the frequent expression of survivin in gastric cancer and in first-degree relatives. Co-expression of survivin and cyclo-oxygenase-2 may suggest multiple pathways contributing to the inhibition of apoptosis in gastric cancer. © 2002 Cancer Research UK.
dc.description.nature	Link_to_subscribed_fulltext
dc.identifier.citation	British Journal Of Cancer, 2002, v. 87 n. 1, p. 91-97 [How to Cite?] DOI: http://dx.doi.org/10.1038/sj.bjc.6600421
dc.identifier.doi	http://dx.doi.org/10.1038/sj.bjc.6600421
dc.identifier.epage	97
dc.identifier.issn	0007-0920 2011 Impact Factor: 5.042 2011 SCImago Journal Rankings: 0.561
dc.identifier.issue	1
dc.identifier.pmid	12085263
dc.identifier.scopus	eid_2-s2.0-0036648414
dc.identifier.spage	91
dc.identifier.uri	http://hdl.handle.net/10722/162624
dc.identifier.volume	87
dc.language	eng
dc.publisher	Nature Publishing Group. The Journal's web site is located at http://www.nature.com/bjc
dc.publisher.place	United Kingdom
dc.relation.ispartof	British Journal of Cancer
dc.relation.references	References in Scopus
dc.subject.mesh	Adult
dc.subject.mesh	Aged
dc.subject.mesh	Aged, 80 And Over
dc.subject.mesh	Apoptosis
dc.subject.mesh	Blotting, Western
dc.subject.mesh	Chromosomal Proteins, Non-Histone - Biosynthesis
dc.subject.mesh	Cyclooxygenase 2
dc.subject.mesh	Female
dc.subject.mesh	Gene Expression Regulation, Neoplastic
dc.subject.mesh	Genetic Predisposition To Disease
dc.subject.mesh	Helicobacter Infections - Complications
dc.subject.mesh	Humans
dc.subject.mesh	Immunohistochemistry
dc.subject.mesh	Inhibitor Of Apoptosis Proteins
dc.subject.mesh	Isoenzymes - Biosynthesis
dc.subject.mesh	Male
dc.subject.mesh	Membrane Proteins
dc.subject.mesh	Microtubule-Associated Proteins
dc.subject.mesh	Middle Aged
dc.subject.mesh	Neoplasm Proteins
dc.subject.mesh	Pedigree
dc.subject.mesh	Prostaglandin-Endoperoxide Synthases - Biosynthesis
dc.subject.mesh	Rna, Messenger - Analysis
dc.subject.mesh	Stomach Neoplasms - Genetics - Physiopathology
dc.subject.mesh	Tumor Cells, Cultured
dc.title	Increased expression of survivin in gastric cancer patients and in first degree relatives
dc.type	Article

<?xml encoding="utf-8" version="1.0"?><item><contributor.author>Yu, J</contributor.author><contributor.author>Leung, WK</contributor.author><contributor.author>Ebert, MPA</contributor.author><contributor.author>Ng, EKW</contributor.author><contributor.author>Go, MYY</contributor.author><contributor.author>Wang, HB</contributor.author><contributor.author>Chung, SCS</contributor.author><contributor.author>Malfertheiner, P</contributor.author><contributor.author>Sung, JJY</contributor.author><date.accessioned>2012-09-05T05:21:48Z</date.accessioned><date.available>2012-09-05T05:21:48Z</date.available><date.issued>2002</date.issued><identifier.citation>British Journal Of Cancer, 2002, v. 87 n. 1, p. 91-97</identifier.citation><identifier.issn>0007-0920</identifier.issn><identifier.uri>http://hdl.handle.net/10722/162624</identifier.uri><description.abstract>Survivin was recently described as an apoptosis inhibitor. Its pathogenic role in gastric cancer is largely unknown. Expression of survivin in gastric cancer and non-cancer first-degree relatives, and its association with apoptosis and cyclo-oxygenase-2 expression was investigated. Fifty gastric cancer, 30 non-cancer first-degree relatives, 20 normal controls and five gastric cancer cell lines were studied. Survivin and cyclo-oxygenase-2 were evaluated by reverse transcriptase-polymerase chain reaction, immunohistochemistry and Western blot. Survivin expression was absent from normal gastric mucosa. All five cancer cell lines and 34 out of 50 (68%) human gastric cancer tissues expressed survivin mRNA. Survivin expression was less frequent (22%; P&lt;0.001) in adjacent non-tumour gastric tissues. Immunohistochemistry and Western blot obtained similar findings. Gastric cancers with survivin expression displayed significantly reduced apoptosis (P=0.02), and associated with cyclo-oxygenase-2 overexpression at both mRNA (P=0.001) and protein levels (P=0.041). Moreover, survivin mRNA was detected in the gastric mucosa of eight (27%) non-cancer relatives. Expression in non-cancer patients showed positive correlation with H. pylori infection (P=0.004). This demonstrates the frequent expression of survivin in gastric cancer and in first-degree relatives. Co-expression of survivin and cyclo-oxygenase-2 may suggest multiple pathways contributing to the inhibition of apoptosis in gastric cancer. &#169; 2002 Cancer Research UK.</description.abstract><language>eng</language><publisher>Nature Publishing Group. The Journal&apos;s web site is located at http://www.nature.com/bjc</publisher><relation.ispartof>British Journal of Cancer</relation.ispartof><subject.mesh>Adult</subject.mesh><subject.mesh>Aged</subject.mesh><subject.mesh>Aged, 80 And Over</subject.mesh><subject.mesh>Apoptosis</subject.mesh><subject.mesh>Blotting, Western</subject.mesh><subject.mesh>Chromosomal Proteins, Non-Histone - Biosynthesis</subject.mesh><subject.mesh>Cyclooxygenase 2</subject.mesh><subject.mesh>Female</subject.mesh><subject.mesh>Gene Expression Regulation, Neoplastic</subject.mesh><subject.mesh>Genetic Predisposition To Disease</subject.mesh><subject.mesh>Helicobacter Infections - Complications</subject.mesh><subject.mesh>Humans</subject.mesh><subject.mesh>Immunohistochemistry</subject.mesh><subject.mesh>Inhibitor Of Apoptosis Proteins</subject.mesh><subject.mesh>Isoenzymes - Biosynthesis</subject.mesh><subject.mesh>Male</subject.mesh><subject.mesh>Membrane Proteins</subject.mesh><subject.mesh>Microtubule-Associated Proteins</subject.mesh><subject.mesh>Middle Aged</subject.mesh><subject.mesh>Neoplasm Proteins</subject.mesh><subject.mesh>Pedigree</subject.mesh><subject.mesh>Prostaglandin-Endoperoxide Synthases - Biosynthesis</subject.mesh><subject.mesh>Rna, Messenger - Analysis</subject.mesh><subject.mesh>Stomach Neoplasms - Genetics - Physiopathology</subject.mesh><subject.mesh>Tumor Cells, Cultured</subject.mesh><title>Increased expression of survivin in gastric cancer patients and in first degree relatives</title><type>Article</type><description.nature>Link_to_subscribed_fulltext</description.nature><identifier.doi>10.1038/sj.bjc.6600421</identifier.doi><identifier.pmid>12085263</identifier.pmid><identifier.scopus>eid_2-s2.0-0036648414</identifier.scopus><relation.references>http://www.scopus.com/mlt/select.url?eid=2-s2.0-0036648414&amp;selection=ref&amp;src=s&amp;origin=recordpage</relation.references><identifier.volume>87</identifier.volume><identifier.issue>1</identifier.issue><identifier.spage>91</identifier.spage><identifier.epage>97</identifier.epage><publisher.place>United Kingdom</publisher.place></item>

Author Affiliations

Prince of Wales Hospital Hong Kong

Article: Increased expression of survivin in gastric cancer patients and in first degree relatives

The HKU Scholars Hub has contact details for these author(s).