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Article: Infrequent hypermethylation of CEBPA promotor in acute myeloid leukaemia

TitleInfrequent hypermethylation of CEBPA promotor in acute myeloid leukaemia
Authors
Issue Date2002
PublisherBlackwell Publishing Ltd. The Journal's web site is located at http://www.blackwellpublishing.com/journals/BJH
Citation
British Journal Of Haematology, 2002, v. 119 n. 4, p. 988-990 How to Cite?
AbstractThe gene CEBPA, encoding the transcription factor C/EBPα, is crucial for granulocyte differentiation. We investigated the frequency of aberrant CEBPA promotor methylation with the methylation-specific polymerase chain reaction in 70 patients with acute myeloid leukaemia (AML). Two patients, both with M2 morphology, were found to have methylated CEBPA. In one of them, the fusion gene AML1/ETO, reported to cause transcription repression of CEBPA, was also present, suggesting that more than one mechanism might collaborate to suppress CEBPA gene expression. Aberrant CEBPA methylation is infrequent in AML, but may occur preferentially in the M2 phenotype.
Persistent Identifierhttp://hdl.handle.net/10722/162615
ISSN
2015 Impact Factor: 5.401
2015 SCImago Journal Rankings: 2.313
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorChim, CSen_US
dc.contributor.authorWong, ASYen_US
dc.contributor.authorKwong, YLen_US
dc.date.accessioned2012-09-05T05:21:42Z-
dc.date.available2012-09-05T05:21:42Z-
dc.date.issued2002en_US
dc.identifier.citationBritish Journal Of Haematology, 2002, v. 119 n. 4, p. 988-990en_US
dc.identifier.issn0007-1048en_US
dc.identifier.urihttp://hdl.handle.net/10722/162615-
dc.description.abstractThe gene CEBPA, encoding the transcription factor C/EBPα, is crucial for granulocyte differentiation. We investigated the frequency of aberrant CEBPA promotor methylation with the methylation-specific polymerase chain reaction in 70 patients with acute myeloid leukaemia (AML). Two patients, both with M2 morphology, were found to have methylated CEBPA. In one of them, the fusion gene AML1/ETO, reported to cause transcription repression of CEBPA, was also present, suggesting that more than one mechanism might collaborate to suppress CEBPA gene expression. Aberrant CEBPA methylation is infrequent in AML, but may occur preferentially in the M2 phenotype.en_US
dc.languageengen_US
dc.publisherBlackwell Publishing Ltd. The Journal's web site is located at http://www.blackwellpublishing.com/journals/BJHen_US
dc.relation.ispartofBritish Journal of Haematologyen_US
dc.rightsBritish Journal of Haematology. Copyright © Blackwell Publishing Ltd.-
dc.subject.meshAcute Diseaseen_US
dc.subject.meshBase Sequenceen_US
dc.subject.meshCcaat-Enhancer-Binding Protein-Alpha - Geneticsen_US
dc.subject.meshDna Methylationen_US
dc.subject.meshDna, Neoplasm - Geneticsen_US
dc.subject.meshHumansen_US
dc.subject.meshLeukemia, Myeloid - Geneticsen_US
dc.subject.meshLeukemia, Myeloid, Acute - Geneticsen_US
dc.subject.meshMolecular Sequence Dataen_US
dc.subject.meshNeoplasm Proteins - Geneticsen_US
dc.subject.meshPolymerase Chain Reaction - Methodsen_US
dc.subject.meshPromoter Regions, Geneticen_US
dc.subject.meshSensitivity And Specificityen_US
dc.titleInfrequent hypermethylation of CEBPA promotor in acute myeloid leukaemiaen_US
dc.typeArticleen_US
dc.identifier.emailChim, CS:jcschim@hku.hken_US
dc.identifier.emailKwong, YL:ylkwong@hku.hken_US
dc.identifier.authorityChim, CS=rp00408en_US
dc.identifier.authorityKwong, YL=rp00358en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1046/j.1365-2141.2002.03952.xen_US
dc.identifier.pmid12472578-
dc.identifier.scopuseid_2-s2.0-0036456441en_US
dc.identifier.hkuros77961-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0036456441&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume119en_US
dc.identifier.issue4en_US
dc.identifier.spage988en_US
dc.identifier.epage990en_US
dc.identifier.isiWOS:000179693100017-
dc.publisher.placeUnited Kingdomen_US
dc.identifier.scopusauthoridChim, CS=7004597253en_US
dc.identifier.scopusauthoridWong, ASY=7403144356en_US
dc.identifier.scopusauthoridKwong, YL=7102818954en_US

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