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Article: Effects of somatostatin, octreotide and pitressin plus nitroglycerine on systemic and portal haemodynamics in the control of acute variceal bleeding
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TitleEffects of somatostatin, octreotide and pitressin plus nitroglycerine on systemic and portal haemodynamics in the control of acute variceal bleeding
 
AuthorsZhang, HB1
Wong, BCY1
Zhou, XM1
Guo, XG1
Zhao, SJ1
Wang, JH1
Wu, KC1
Ding, J1
Lam, SK1
Fan, DM1
 
Issue Date2002
 
PublisherBlackwell Publishing Ltd. The Journal's web site is located at http://www.blackwellpublishing.com/journals/IJCP
 
CitationInternational Journal Of Clinical Practice, 2002, v. 56 n. 6, p. 447-451 [How to Cite?]
 
AbstractTo examine the haemodynamic effects of somatostatin (SS) and octreotide (OC) versus pitressin plus nitroglycerine (PN) in the control of variceal bleeding, 224 patients with acute oesophageal and gastric variceal haemorrhage were randomly divided into three groups and treated with SS, OC and PN; they also had their Doppler ultrasound parameters measured before, during and after treatment. The success rates of bleeding control in the SS (80.9%, 86.8% and 89.7%, p < 0.001) and OC (75.3%, 80.8% and 84.9%, p < 0.01) groups were significantly higher than in the PN group (51.8%, 59.0% and 65.1 %) at 24, 48 and 72 hours respectively, and the average duration of SS (12.7 + 6.8 h) And OC (13.8 + 8.0 h) was significantly lower than that of PN (24.6 + 15.4 h, p < 0.001). Side-effects of SS (7.4%) and OC (8.2%) were less than those of PN (41.0%, p < 0.001 and p < 0.01). The diameter of portal vein (PVD), velocity of portal vein (PVV), volume of portal blood flow (PVF) and hepatic artery pulsatility index (HA-PI) in all three groups decreased significantly during initial treatment, but recovered when treatment was stopped. Heart rate and cardiac output decreased significantly in patients treated with SS and OC; mean arterial pressure was unchanged. However, heart rate and mean arterial pressure increased, and cardiac output decreased, with PN. Somatostatin and octreotide were more effective than pitressin plus nitroglycerine in patients with acute variceal haemorrhage, with fewer side-effects, and may decrease PVF and portal vein pressure through reduction of cardiac output and dilatation of the visceral blood vessels.
 
ISSN1368-5031
2013 Impact Factor: 2.538
 
ReferencesReferences in Scopus
 
DC FieldValue
dc.contributor.authorZhang, HB
 
dc.contributor.authorWong, BCY
 
dc.contributor.authorZhou, XM
 
dc.contributor.authorGuo, XG
 
dc.contributor.authorZhao, SJ
 
dc.contributor.authorWang, JH
 
dc.contributor.authorWu, KC
 
dc.contributor.authorDing, J
 
dc.contributor.authorLam, SK
 
dc.contributor.authorFan, DM
 
dc.date.accessioned2012-09-05T05:21:36Z
 
dc.date.available2012-09-05T05:21:36Z
 
dc.date.issued2002
 
dc.description.abstractTo examine the haemodynamic effects of somatostatin (SS) and octreotide (OC) versus pitressin plus nitroglycerine (PN) in the control of variceal bleeding, 224 patients with acute oesophageal and gastric variceal haemorrhage were randomly divided into three groups and treated with SS, OC and PN; they also had their Doppler ultrasound parameters measured before, during and after treatment. The success rates of bleeding control in the SS (80.9%, 86.8% and 89.7%, p < 0.001) and OC (75.3%, 80.8% and 84.9%, p < 0.01) groups were significantly higher than in the PN group (51.8%, 59.0% and 65.1 %) at 24, 48 and 72 hours respectively, and the average duration of SS (12.7 + 6.8 h) And OC (13.8 + 8.0 h) was significantly lower than that of PN (24.6 + 15.4 h, p < 0.001). Side-effects of SS (7.4%) and OC (8.2%) were less than those of PN (41.0%, p < 0.001 and p < 0.01). The diameter of portal vein (PVD), velocity of portal vein (PVV), volume of portal blood flow (PVF) and hepatic artery pulsatility index (HA-PI) in all three groups decreased significantly during initial treatment, but recovered when treatment was stopped. Heart rate and cardiac output decreased significantly in patients treated with SS and OC; mean arterial pressure was unchanged. However, heart rate and mean arterial pressure increased, and cardiac output decreased, with PN. Somatostatin and octreotide were more effective than pitressin plus nitroglycerine in patients with acute variceal haemorrhage, with fewer side-effects, and may decrease PVF and portal vein pressure through reduction of cardiac output and dilatation of the visceral blood vessels.
 
dc.description.naturelink_to_subscribed_fulltext
 
dc.identifier.citationInternational Journal Of Clinical Practice, 2002, v. 56 n. 6, p. 447-451 [How to Cite?]
 
dc.identifier.epage451
 
dc.identifier.hkuros72444
 
dc.identifier.issn1368-5031
2013 Impact Factor: 2.538
 
dc.identifier.issue6
 
dc.identifier.pmid12166543
 
dc.identifier.scopuseid_2-s2.0-0036332450
 
dc.identifier.spage447
 
dc.identifier.urihttp://hdl.handle.net/10722/162605
 
dc.identifier.volume56
 
dc.languageeng
 
dc.publisherBlackwell Publishing Ltd. The Journal's web site is located at http://www.blackwellpublishing.com/journals/IJCP
 
dc.publisher.placeUnited Kingdom
 
dc.relation.ispartofInternational Journal of Clinical Practice
 
dc.relation.referencesReferences in Scopus
 
dc.rightsInternational Journal of Clinical Practice. Copyright © Blackwell Publishing Ltd.
 
dc.subject.meshAcute Disease
 
dc.subject.meshArginine Vasopressin - Therapeutic Use
 
dc.subject.meshDrug Therapy, Combination
 
dc.subject.meshEsophageal And Gastric Varices - Drug Therapy - Physiopathology - Ultrasonography
 
dc.subject.meshFemale
 
dc.subject.meshGastrointestinal Hemorrhage - Drug Therapy - Physiopathology - Ultrasonography
 
dc.subject.meshHemodynamics - Drug Effects
 
dc.subject.meshHepatic Artery - Ultrasonography
 
dc.subject.meshHumans
 
dc.subject.meshLiver Cirrhosis - Complications - Physiopathology - Ultrasonography
 
dc.subject.meshMale
 
dc.subject.meshMiddle Aged
 
dc.subject.meshNitroglycerin - Therapeutic Use
 
dc.subject.meshOctreotide - Therapeutic Use
 
dc.subject.meshPortal System - Physiopathology
 
dc.subject.meshPortal Vein - Ultrasonography
 
dc.subject.meshRegression Analysis
 
dc.subject.meshSomatostatin - Therapeutic Use
 
dc.subject.meshVasoconstrictor Agents - Therapeutic Use
 
dc.subject.meshVasodilator Agents - Therapeutic Use
 
dc.titleEffects of somatostatin, octreotide and pitressin plus nitroglycerine on systemic and portal haemodynamics in the control of acute variceal bleeding
 
dc.typeArticle
 
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<contributor.author>Zhao, SJ</contributor.author>
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Author Affiliations
  1. Xijing Hospital