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Article: Effects of somatostatin, octreotide and pitressin plus nitroglycerine on systemic and portal haemodynamics in the control of acute variceal bleeding

TitleEffects of somatostatin, octreotide and pitressin plus nitroglycerine on systemic and portal haemodynamics in the control of acute variceal bleeding
Authors
Issue Date2002
PublisherBlackwell Publishing Ltd. The Journal's web site is located at http://www.blackwellpublishing.com/journals/IJCP
Citation
International Journal Of Clinical Practice, 2002, v. 56 n. 6, p. 447-451 How to Cite?
AbstractTo examine the haemodynamic effects of somatostatin (SS) and octreotide (OC) versus pitressin plus nitroglycerine (PN) in the control of variceal bleeding, 224 patients with acute oesophageal and gastric variceal haemorrhage were randomly divided into three groups and treated with SS, OC and PN; they also had their Doppler ultrasound parameters measured before, during and after treatment. The success rates of bleeding control in the SS (80.9%, 86.8% and 89.7%, p < 0.001) and OC (75.3%, 80.8% and 84.9%, p < 0.01) groups were significantly higher than in the PN group (51.8%, 59.0% and 65.1 %) at 24, 48 and 72 hours respectively, and the average duration of SS (12.7 + 6.8 h) And OC (13.8 + 8.0 h) was significantly lower than that of PN (24.6 + 15.4 h, p < 0.001). Side-effects of SS (7.4%) and OC (8.2%) were less than those of PN (41.0%, p < 0.001 and p < 0.01). The diameter of portal vein (PVD), velocity of portal vein (PVV), volume of portal blood flow (PVF) and hepatic artery pulsatility index (HA-PI) in all three groups decreased significantly during initial treatment, but recovered when treatment was stopped. Heart rate and cardiac output decreased significantly in patients treated with SS and OC; mean arterial pressure was unchanged. However, heart rate and mean arterial pressure increased, and cardiac output decreased, with PN. Somatostatin and octreotide were more effective than pitressin plus nitroglycerine in patients with acute variceal haemorrhage, with fewer side-effects, and may decrease PVF and portal vein pressure through reduction of cardiac output and dilatation of the visceral blood vessels.
Persistent Identifierhttp://hdl.handle.net/10722/162605
ISSN
2015 Impact Factor: 2.226
2015 SCImago Journal Rankings: 0.759
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorZhang, HBen_US
dc.contributor.authorWong, BCYen_US
dc.contributor.authorZhou, XMen_US
dc.contributor.authorGuo, XGen_US
dc.contributor.authorZhao, SJen_US
dc.contributor.authorWang, JHen_US
dc.contributor.authorWu, KCen_US
dc.contributor.authorDing, Jen_US
dc.contributor.authorLam, SKen_US
dc.contributor.authorFan, DMen_US
dc.date.accessioned2012-09-05T05:21:36Z-
dc.date.available2012-09-05T05:21:36Z-
dc.date.issued2002en_US
dc.identifier.citationInternational Journal Of Clinical Practice, 2002, v. 56 n. 6, p. 447-451en_US
dc.identifier.issn1368-5031en_US
dc.identifier.urihttp://hdl.handle.net/10722/162605-
dc.description.abstractTo examine the haemodynamic effects of somatostatin (SS) and octreotide (OC) versus pitressin plus nitroglycerine (PN) in the control of variceal bleeding, 224 patients with acute oesophageal and gastric variceal haemorrhage were randomly divided into three groups and treated with SS, OC and PN; they also had their Doppler ultrasound parameters measured before, during and after treatment. The success rates of bleeding control in the SS (80.9%, 86.8% and 89.7%, p < 0.001) and OC (75.3%, 80.8% and 84.9%, p < 0.01) groups were significantly higher than in the PN group (51.8%, 59.0% and 65.1 %) at 24, 48 and 72 hours respectively, and the average duration of SS (12.7 + 6.8 h) And OC (13.8 + 8.0 h) was significantly lower than that of PN (24.6 + 15.4 h, p < 0.001). Side-effects of SS (7.4%) and OC (8.2%) were less than those of PN (41.0%, p < 0.001 and p < 0.01). The diameter of portal vein (PVD), velocity of portal vein (PVV), volume of portal blood flow (PVF) and hepatic artery pulsatility index (HA-PI) in all three groups decreased significantly during initial treatment, but recovered when treatment was stopped. Heart rate and cardiac output decreased significantly in patients treated with SS and OC; mean arterial pressure was unchanged. However, heart rate and mean arterial pressure increased, and cardiac output decreased, with PN. Somatostatin and octreotide were more effective than pitressin plus nitroglycerine in patients with acute variceal haemorrhage, with fewer side-effects, and may decrease PVF and portal vein pressure through reduction of cardiac output and dilatation of the visceral blood vessels.en_US
dc.languageengen_US
dc.publisherBlackwell Publishing Ltd. The Journal's web site is located at http://www.blackwellpublishing.com/journals/IJCPen_US
dc.relation.ispartofInternational Journal of Clinical Practiceen_US
dc.rightsInternational Journal of Clinical Practice. Copyright © Blackwell Publishing Ltd.-
dc.subject.meshAcute Diseaseen_US
dc.subject.meshArginine Vasopressin - Therapeutic Useen_US
dc.subject.meshDrug Therapy, Combinationen_US
dc.subject.meshEsophageal And Gastric Varices - Drug Therapy - Physiopathology - Ultrasonographyen_US
dc.subject.meshFemaleen_US
dc.subject.meshGastrointestinal Hemorrhage - Drug Therapy - Physiopathology - Ultrasonographyen_US
dc.subject.meshHemodynamics - Drug Effectsen_US
dc.subject.meshHepatic Artery - Ultrasonographyen_US
dc.subject.meshHumansen_US
dc.subject.meshLiver Cirrhosis - Complications - Physiopathology - Ultrasonographyen_US
dc.subject.meshMaleen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshNitroglycerin - Therapeutic Useen_US
dc.subject.meshOctreotide - Therapeutic Useen_US
dc.subject.meshPortal System - Physiopathologyen_US
dc.subject.meshPortal Vein - Ultrasonographyen_US
dc.subject.meshRegression Analysisen_US
dc.subject.meshSomatostatin - Therapeutic Useen_US
dc.subject.meshVasoconstrictor Agents - Therapeutic Useen_US
dc.subject.meshVasodilator Agents - Therapeutic Useen_US
dc.titleEffects of somatostatin, octreotide and pitressin plus nitroglycerine on systemic and portal haemodynamics in the control of acute variceal bleedingen_US
dc.typeArticleen_US
dc.identifier.emailWong, BCY:bcywong@hku.hken_US
dc.identifier.authorityWong, BCY=rp00429en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.pmid12166543-
dc.identifier.scopuseid_2-s2.0-0036332450en_US
dc.identifier.hkuros72444-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0036332450&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume56en_US
dc.identifier.issue6en_US
dc.identifier.spage447en_US
dc.identifier.epage451en_US
dc.identifier.isiWOS:000177188500009-
dc.publisher.placeUnited Kingdomen_US
dc.identifier.scopusauthoridZhang, HB=8980454900en_US
dc.identifier.scopusauthoridWong, BCY=7402023340en_US
dc.identifier.scopusauthoridZhou, XM=7410092583en_US
dc.identifier.scopusauthoridGuo, XG=16743725400en_US
dc.identifier.scopusauthoridZhao, SJ=7403577933en_US
dc.identifier.scopusauthoridWang, JH=12753482600en_US
dc.identifier.scopusauthoridWu, KC=8947728400en_US
dc.identifier.scopusauthoridDing, J=7402608820en_US
dc.identifier.scopusauthoridLam, SK=7402279473en_US
dc.identifier.scopusauthoridFan, DM=7202965595en_US

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