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Article: Left ventricular long-axis changes in early diastole and systole impact of systolic function on diastole

TitleLeft ventricular long-axis changes in early diastole and systole impact of systolic function on diastole
Authors
Issue Date2002
PublisherPortland Press Ltd. The Journal's web site is located at http://www.clinsci.org/
Citation
Clinical Science, 2002, v. 102 n. 5, p. 515-522 How to Cite?
AbstractImpaired long-axis motion is a sensitive marker of systolic myocardial dysfunction, but no data are available that relate long-axis changes in systole with those in diastole, particularly in subjects with diastolic dysfunction and a 'normal' left ventricular (LV) ejection fraction. A total of 311 subjects (including 105 normal healthy volunteers) aged 20-89 years with variable degrees of systolic function (LV ejection fraction range 0.15-0.84) and diastolic function were studied using tissue Doppler echocardiography and M-mode echocardiography to determine mean mitral annular amplitude and peak velocity in systole and early and late diastole. The LV systolic mitral annular amplitude (SLAX, where LAX is long-axis amplitude) and peak velocity (Sm) correlated well with the respective early diastolic components (ELAX and Em) and late diastolic (atrial) components (ALAX and Am). A non-linear equation fitted better than a linear relationship (non-linear model: SLAX against ELAX, r2 = 0.67; Sm against Em, r2 = 0.60; SLAX against ALAX and Sm against Am, r2 = 0.42). After adjusting for age, sex and heart rate, linear relationships of early diastolic (ELAX, r2 = 0.70; Em, r2 = 0.60) and late diastolic (ALAX, r2 = 0.61; Am, r2 = 0.64) long-axis amplitudes and velocities with the respective values for SLAX and Sm were found, even in those subjects with apparently 'isolated' diastolic dysfunction. Long-axis changes in systole or diastole did not correlate with Doppler mitral velocities. We conclude that ventricular long-axis changes in early diastole are closely related to systolic function, even in subjects with diastolic dysfunction. 'Pure' or isolated diastolic dysfunction is uncommon.
Persistent Identifierhttp://hdl.handle.net/10722/162597
ISSN
2015 Impact Factor: 4.996
2015 SCImago Journal Rankings: 2.427
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorYip, GWen_US
dc.contributor.authorZhang, Yen_US
dc.contributor.authorTan, PYen_US
dc.contributor.authorWang, Men_US
dc.contributor.authorHo, PYen_US
dc.contributor.authorBrodin, LÅen_US
dc.contributor.authorSanderson, JEen_US
dc.date.accessioned2012-09-05T05:21:33Z-
dc.date.available2012-09-05T05:21:33Z-
dc.date.issued2002en_US
dc.identifier.citationClinical Science, 2002, v. 102 n. 5, p. 515-522en_US
dc.identifier.issn0143-5221en_US
dc.identifier.urihttp://hdl.handle.net/10722/162597-
dc.description.abstractImpaired long-axis motion is a sensitive marker of systolic myocardial dysfunction, but no data are available that relate long-axis changes in systole with those in diastole, particularly in subjects with diastolic dysfunction and a 'normal' left ventricular (LV) ejection fraction. A total of 311 subjects (including 105 normal healthy volunteers) aged 20-89 years with variable degrees of systolic function (LV ejection fraction range 0.15-0.84) and diastolic function were studied using tissue Doppler echocardiography and M-mode echocardiography to determine mean mitral annular amplitude and peak velocity in systole and early and late diastole. The LV systolic mitral annular amplitude (SLAX, where LAX is long-axis amplitude) and peak velocity (Sm) correlated well with the respective early diastolic components (ELAX and Em) and late diastolic (atrial) components (ALAX and Am). A non-linear equation fitted better than a linear relationship (non-linear model: SLAX against ELAX, r2 = 0.67; Sm against Em, r2 = 0.60; SLAX against ALAX and Sm against Am, r2 = 0.42). After adjusting for age, sex and heart rate, linear relationships of early diastolic (ELAX, r2 = 0.70; Em, r2 = 0.60) and late diastolic (ALAX, r2 = 0.61; Am, r2 = 0.64) long-axis amplitudes and velocities with the respective values for SLAX and Sm were found, even in those subjects with apparently 'isolated' diastolic dysfunction. Long-axis changes in systole or diastole did not correlate with Doppler mitral velocities. We conclude that ventricular long-axis changes in early diastole are closely related to systolic function, even in subjects with diastolic dysfunction. 'Pure' or isolated diastolic dysfunction is uncommon.en_US
dc.languageengen_US
dc.publisherPortland Press Ltd. The Journal's web site is located at http://www.clinsci.org/en_US
dc.relation.ispartofClinical Scienceen_US
dc.subject.meshAdulten_US
dc.subject.meshAge Distributionen_US
dc.subject.meshAgeden_US
dc.subject.meshAged, 80 And Overen_US
dc.subject.meshAging - Physiologyen_US
dc.subject.meshBlood Flow Velocityen_US
dc.subject.meshDiastoleen_US
dc.subject.meshEchocardiography, Doppleren_US
dc.subject.meshFemaleen_US
dc.subject.meshHumansen_US
dc.subject.meshLinear Modelsen_US
dc.subject.meshMaleen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshMitral Valve - Physiopathologyen_US
dc.subject.meshSex Distributionen_US
dc.subject.meshStroke Volumeen_US
dc.subject.meshSystoleen_US
dc.subject.meshVentricular Dysfunction, Left - Physiopathology - Ultrasonographyen_US
dc.titleLeft ventricular long-axis changes in early diastole and systole impact of systolic function on diastoleen_US
dc.typeArticleen_US
dc.identifier.emailWang, M:meiwang@hkucc.hku.hken_US
dc.identifier.authorityWang, M=rp00281en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1042/CS20010196en_US
dc.identifier.pmid11980570-
dc.identifier.scopuseid_2-s2.0-0036257572en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0036257572&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume102en_US
dc.identifier.issue5en_US
dc.identifier.spage515en_US
dc.identifier.epage522en_US
dc.identifier.isiWOS:000175487600007-
dc.publisher.placeUnited Kingdomen_US
dc.identifier.scopusauthoridYip, GW=7006525328en_US
dc.identifier.scopusauthoridZhang, Y=7601312580en_US
dc.identifier.scopusauthoridTan, PY=7201942139en_US
dc.identifier.scopusauthoridWang, M=7406690398en_US
dc.identifier.scopusauthoridHo, PY=14019449500en_US
dc.identifier.scopusauthoridBrodin, LÅ=23130550300en_US
dc.identifier.scopusauthoridSanderson, JE=7202371250en_US

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