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Article: Comparison of two new rapid serology tests for diagnosis of Helicobacter pylori infection in Chinese patients

TitleComparison of two new rapid serology tests for diagnosis of Helicobacter pylori infection in Chinese patients
Authors
Issue Date2002
PublisherWB Saunders Co Ltd. The Journal's web site is located at http://www.elsevier.com/locate/dld
Citation
Digestive And Liver Disease, 2002, v. 34 n. 2, p. 111-115 How to Cite?
AbstractBackground. Rapid serology test is a simple and convenient way for diagnosing Helicobacter pylori infection. However, performances of these tests are usually less satisfactory than expected, particularly in developing countries. Aim. To evaluate the performances of two newly developed rapid serology tests for Helicobacter pylori infection. Patients. Consecutive Chinese dyspeptic patients undergoing upper gastrointestinal endoscopy. Methods. Gastric biopsies were obtained from antrum and corpus for rapid urease test and histological examination. Diagnosis of Helicobacter pylori infection was based on two or more positive results in rapid urease test, histology and [ 13C] urea breath test. Patients' sera were tested against two rapid serology tests: ASSURE Hp Rapid Test (Genelabs Diagnostics, Singapore) and SureStep (Applied Biotech, San Diego, CA, USA). Results. A total of 148 patients were evaluated and Helicobacter pylori infection was diagnosed in 78 (53%) patients by gold standard. The sensitivities of ASSURE Hp and SureStep were, respectively, 94% and 71% (p = 0.0003). Specificities of the two test kits were both 90%. The overall accuracy of ASSURE Hp was significantly higher than SureStep (92% versus 80%, p = 0.004). Conclusion. Both rapid serology tests appear to be specific in diagnosing Helicobacter pylori infection in the Chinese populations. However, the ASSURE Hp test is more sensitive and accurate than the SureStep test.
Persistent Identifierhttp://hdl.handle.net/10722/162588
ISSN
2015 Impact Factor: 2.719
2015 SCImago Journal Rankings: 1.048
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorHung, CTen_US
dc.contributor.authorLeung, WKen_US
dc.contributor.authorChan, FKLen_US
dc.contributor.authorSung, JJYen_US
dc.date.accessioned2012-09-05T05:21:29Z-
dc.date.available2012-09-05T05:21:29Z-
dc.date.issued2002en_US
dc.identifier.citationDigestive And Liver Disease, 2002, v. 34 n. 2, p. 111-115en_US
dc.identifier.issn1590-8658en_US
dc.identifier.urihttp://hdl.handle.net/10722/162588-
dc.description.abstractBackground. Rapid serology test is a simple and convenient way for diagnosing Helicobacter pylori infection. However, performances of these tests are usually less satisfactory than expected, particularly in developing countries. Aim. To evaluate the performances of two newly developed rapid serology tests for Helicobacter pylori infection. Patients. Consecutive Chinese dyspeptic patients undergoing upper gastrointestinal endoscopy. Methods. Gastric biopsies were obtained from antrum and corpus for rapid urease test and histological examination. Diagnosis of Helicobacter pylori infection was based on two or more positive results in rapid urease test, histology and [ 13C] urea breath test. Patients' sera were tested against two rapid serology tests: ASSURE Hp Rapid Test (Genelabs Diagnostics, Singapore) and SureStep (Applied Biotech, San Diego, CA, USA). Results. A total of 148 patients were evaluated and Helicobacter pylori infection was diagnosed in 78 (53%) patients by gold standard. The sensitivities of ASSURE Hp and SureStep were, respectively, 94% and 71% (p = 0.0003). Specificities of the two test kits were both 90%. The overall accuracy of ASSURE Hp was significantly higher than SureStep (92% versus 80%, p = 0.004). Conclusion. Both rapid serology tests appear to be specific in diagnosing Helicobacter pylori infection in the Chinese populations. However, the ASSURE Hp test is more sensitive and accurate than the SureStep test.en_US
dc.languageengen_US
dc.publisherWB Saunders Co Ltd. The Journal's web site is located at http://www.elsevier.com/locate/dlden_US
dc.relation.ispartofDigestive and Liver Diseaseen_US
dc.subject.meshAdulten_US
dc.subject.meshAgeden_US
dc.subject.meshAged, 80 And Overen_US
dc.subject.meshBiopsyen_US
dc.subject.meshBreath Testsen_US
dc.subject.meshEnzyme-Linked Immunosorbent Assayen_US
dc.subject.meshFemaleen_US
dc.subject.meshGastritis - Diagnosis - Microbiologyen_US
dc.subject.meshGastroscopyen_US
dc.subject.meshHelicobacter Infections - Diagnosis - Enzymology - Metabolism - Microbiologyen_US
dc.subject.meshHelicobacter Pylori - Enzymology - Isolation & Purification - Metabolismen_US
dc.subject.meshHumansen_US
dc.subject.meshMaleen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshReproducibility Of Resultsen_US
dc.subject.meshSensitivity And Specificityen_US
dc.subject.meshUrea - Analysisen_US
dc.subject.meshUrease - Blooden_US
dc.titleComparison of two new rapid serology tests for diagnosis of Helicobacter pylori infection in Chinese patientsen_US
dc.typeArticleen_US
dc.identifier.emailLeung, WK:waikleung@hku.hken_US
dc.identifier.authorityLeung, WK=rp01479en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1016/S1590-8658(02)80239-0en_US
dc.identifier.pmid11926553-
dc.identifier.scopuseid_2-s2.0-0036190190en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0036190190&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume34en_US
dc.identifier.issue2en_US
dc.identifier.spage111en_US
dc.identifier.epage115en_US
dc.identifier.isiWOS:000174325800006-
dc.publisher.placeUnited Kingdomen_US
dc.identifier.scopusauthoridHung, CT=7403166798en_US
dc.identifier.scopusauthoridLeung, WK=7201504523en_US
dc.identifier.scopusauthoridChan, FKL=7202586434en_US
dc.identifier.scopusauthoridSung, JJY=24473715000en_US

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