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Article: Transforming growth factor-beta 1, activin and follistatin in patients with hepatocellular carcinoma and patients with alcoholic cirrhosis

TitleTransforming growth factor-beta 1, activin and follistatin in patients with hepatocellular carcinoma and patients with alcoholic cirrhosis
Authors
Issue Date2002
PublisherInforma Healthcare. The Journal's web site is located at http://www.tandf.co.uk/journals/titles/00365521.asp
Citation
Scandinavian Journal Of Gastroenterology, 2002, v. 37 n. 2, p. 233-238 How to Cite?
AbstractBackground: Transforming growth factor-beta 1 (TGF-β1) exerts an inhibitory effect on DNA synthesis in hepatocytes. Activin, through different mechanisms, also exhibits an apoptotic effect on hepatocytes. Follistatin antagonizes the actions of activin. Methods: Patients with hepatocellular carcinoma (HCC, n = 20), patients with alcoholic cirrhosis (n = 12), patients with cirrhosis due to other causes (n = 5) and normal controls (n = 19) were studied. TGF-β1, activin and follistatin concentrations in blood and ascites were measured by ELISA. Results: All three groups of patients had significantly higher serum levels of total TGF-β1, activin and follistatin compared to those of controls. In patients with HCC, the total TGF-β1 level correlated negatively with tumour size (r = -0.644, P = 0.001). The activin level correlated with alkaline phosphatase (ALP) level (r= 0.374, P = 0.046). The follistatin level correlated with the ALP level (r = 0.404, P = 0.026), and the glutamyl transpeptidase level (r = 0.457, P = 0.01). In patients with alcoholic cirrhosis, serum activin correlated with the Child-Pugh score (r = 0.601, P = 0.01). The levels of the cytokines in ascites (n = 16) did not correlate with the corresponding levels in serum. Conclusions: Serum levels of total TGF-β1, activin and follistatin were elevated in patients with hepatocellular carcinoma and in patients with alcoholic cirrhosis. Apoptosis of tumour cells may be reduced by a subsequent decrease in serum TGF-β1 levels when the tumours expand in size. Activin and follistatin were associated with tumour activity, as both correlated with ALP and/or GGT levels. Further studies are required to define the exact relationships between these cytokines, the dynamics of tumour growth and their significance in cirrhosis.
Persistent Identifierhttp://hdl.handle.net/10722/162581
ISSN
2015 Impact Factor: 2.199
2015 SCImago Journal Rankings: 0.891
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorYuen, MFen_US
dc.contributor.authorNorris, Sen_US
dc.contributor.authorEvans, LWen_US
dc.contributor.authorLangley, PGen_US
dc.contributor.authorHughes, RDen_US
dc.date.accessioned2012-09-05T05:21:22Z-
dc.date.available2012-09-05T05:21:22Z-
dc.date.issued2002en_US
dc.identifier.citationScandinavian Journal Of Gastroenterology, 2002, v. 37 n. 2, p. 233-238en_US
dc.identifier.issn0036-5521en_US
dc.identifier.urihttp://hdl.handle.net/10722/162581-
dc.description.abstractBackground: Transforming growth factor-beta 1 (TGF-β1) exerts an inhibitory effect on DNA synthesis in hepatocytes. Activin, through different mechanisms, also exhibits an apoptotic effect on hepatocytes. Follistatin antagonizes the actions of activin. Methods: Patients with hepatocellular carcinoma (HCC, n = 20), patients with alcoholic cirrhosis (n = 12), patients with cirrhosis due to other causes (n = 5) and normal controls (n = 19) were studied. TGF-β1, activin and follistatin concentrations in blood and ascites were measured by ELISA. Results: All three groups of patients had significantly higher serum levels of total TGF-β1, activin and follistatin compared to those of controls. In patients with HCC, the total TGF-β1 level correlated negatively with tumour size (r = -0.644, P = 0.001). The activin level correlated with alkaline phosphatase (ALP) level (r= 0.374, P = 0.046). The follistatin level correlated with the ALP level (r = 0.404, P = 0.026), and the glutamyl transpeptidase level (r = 0.457, P = 0.01). In patients with alcoholic cirrhosis, serum activin correlated with the Child-Pugh score (r = 0.601, P = 0.01). The levels of the cytokines in ascites (n = 16) did not correlate with the corresponding levels in serum. Conclusions: Serum levels of total TGF-β1, activin and follistatin were elevated in patients with hepatocellular carcinoma and in patients with alcoholic cirrhosis. Apoptosis of tumour cells may be reduced by a subsequent decrease in serum TGF-β1 levels when the tumours expand in size. Activin and follistatin were associated with tumour activity, as both correlated with ALP and/or GGT levels. Further studies are required to define the exact relationships between these cytokines, the dynamics of tumour growth and their significance in cirrhosis.en_US
dc.languageengen_US
dc.publisherInforma Healthcare. The Journal's web site is located at http://www.tandf.co.uk/journals/titles/00365521.aspen_US
dc.relation.ispartofScandinavian Journal of Gastroenterologyen_US
dc.subject.meshActivins - Blooden_US
dc.subject.meshApoptosisen_US
dc.subject.meshCarcinoma, Hepatocellular - Blooden_US
dc.subject.meshCase-Control Studiesen_US
dc.subject.meshEnzyme-Linked Immunosorbent Assayen_US
dc.subject.meshFemaleen_US
dc.subject.meshFollistatinen_US
dc.subject.meshHumansen_US
dc.subject.meshLiver Cirrhosis, Alcoholic - Blooden_US
dc.subject.meshLiver Neoplasms - Blooden_US
dc.subject.meshMaleen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshTransforming Growth Factor Beta - Blooden_US
dc.titleTransforming growth factor-beta 1, activin and follistatin in patients with hepatocellular carcinoma and patients with alcoholic cirrhosisen_US
dc.typeArticleen_US
dc.identifier.emailYuen, MF:mfyuen@hkucc.hku.hken_US
dc.identifier.authorityYuen, MF=rp00479en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1080/003655202753416939en_US
dc.identifier.pmid11843063-
dc.identifier.scopuseid_2-s2.0-0036152614en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0036152614&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume37en_US
dc.identifier.issue2en_US
dc.identifier.spage233en_US
dc.identifier.epage238en_US
dc.identifier.isiWOS:000173584600019-
dc.publisher.placeUnited Kingdomen_US
dc.identifier.scopusauthoridYuen, MF=7102031955en_US
dc.identifier.scopusauthoridNorris, S=7103213449en_US
dc.identifier.scopusauthoridEvans, LW=7401487874en_US
dc.identifier.scopusauthoridLangley, PG=7102314638en_US
dc.identifier.scopusauthoridHughes, RD=7404305534en_US

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