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Article: Estrogen receptor β gene polymorphisms are associated with higher bone mineral density in premenopausal, but not postmenopausal southern Chinese women

TitleEstrogen receptor β gene polymorphisms are associated with higher bone mineral density in premenopausal, but not postmenopausal southern Chinese women
Authors
KeywordsBone mineral density (BMD)
Estrogen receptor (ER)
Southern Chinese women
Issue Date2002
PublisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/bone
Citation
Bone, 2002, v. 31 n. 2, p. 276-281 How to Cite?
AbstractBone mineral density (BMD), the main determining risk factor for osteoporotic fractures, has a strong genetic component. Estrogen and its receptors play a critical role in both skeletal maturity and bone loss. We investigated the association between dinucleotide (cytosine-adenine; CA) repeat polymorphisms located in the flanking region of the estrogen receptor β gene and bone mineral density (BMD) in 325 healthy southern Chinese women. BMD at the lumbar spine and hip region were measured using dual-energy X-ray absorptiometry (DEXA). The number of the repeats observed in our population ranged from 16 to 28. After adjusting for age, height, weight, and years of estrogen exposure, we observed that premenopausal subjects (n = 120) bearing at least one allele of 20 CA repeats had significantly higher BMD at the L2-4 lumbar spine (1.049 ± 0.016 vs. 0.984 ± 0.015; p = 0.01), total hip (0.836 ± 0.014 vs. 0.813 ± 0.013; p < 0.02), femoral neck (0.773 ± 0.014 vs. 0.728 ± 0.013; p = 0.02), trochanter (0.665 ± 0.013 vs. 0.614 ± 0.012; p = 0.01), and Ward's triangle (0.715 ± 0.017 vs. 0.651 ± 0.016; p = 0.02). There was no difference in the vertebral area of L-3 and femoral neck width in these premenopausal women with or without 20 CA repeats. However, in postmenopausal women (n = 205), Estrogen receptor β (ERβ) gene polymorphisms were not related to BMD at any skeletal site. We conclude that ERβ gene polymorphisms are associated with higher BMD in premenopausal women, suggesting that the ERβ gene may have a modulatory role in bone metabolism in young adulthood. Copyright © 2002 Elsevier Science Inc.
Persistent Identifierhttp://hdl.handle.net/10722/162570
ISSN
2015 Impact Factor: 3.736
2015 SCImago Journal Rankings: 1.752
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorLau, HHLen_US
dc.contributor.authorHo, AYYen_US
dc.contributor.authorLuk, KDKen_US
dc.contributor.authorKung, AWCen_US
dc.date.accessioned2012-09-05T05:21:17Z-
dc.date.available2012-09-05T05:21:17Z-
dc.date.issued2002en_US
dc.identifier.citationBone, 2002, v. 31 n. 2, p. 276-281en_US
dc.identifier.issn8756-3282en_US
dc.identifier.urihttp://hdl.handle.net/10722/162570-
dc.description.abstractBone mineral density (BMD), the main determining risk factor for osteoporotic fractures, has a strong genetic component. Estrogen and its receptors play a critical role in both skeletal maturity and bone loss. We investigated the association between dinucleotide (cytosine-adenine; CA) repeat polymorphisms located in the flanking region of the estrogen receptor β gene and bone mineral density (BMD) in 325 healthy southern Chinese women. BMD at the lumbar spine and hip region were measured using dual-energy X-ray absorptiometry (DEXA). The number of the repeats observed in our population ranged from 16 to 28. After adjusting for age, height, weight, and years of estrogen exposure, we observed that premenopausal subjects (n = 120) bearing at least one allele of 20 CA repeats had significantly higher BMD at the L2-4 lumbar spine (1.049 ± 0.016 vs. 0.984 ± 0.015; p = 0.01), total hip (0.836 ± 0.014 vs. 0.813 ± 0.013; p < 0.02), femoral neck (0.773 ± 0.014 vs. 0.728 ± 0.013; p = 0.02), trochanter (0.665 ± 0.013 vs. 0.614 ± 0.012; p = 0.01), and Ward's triangle (0.715 ± 0.017 vs. 0.651 ± 0.016; p = 0.02). There was no difference in the vertebral area of L-3 and femoral neck width in these premenopausal women with or without 20 CA repeats. However, in postmenopausal women (n = 205), Estrogen receptor β (ERβ) gene polymorphisms were not related to BMD at any skeletal site. We conclude that ERβ gene polymorphisms are associated with higher BMD in premenopausal women, suggesting that the ERβ gene may have a modulatory role in bone metabolism in young adulthood. Copyright © 2002 Elsevier Science Inc.en_US
dc.languageengen_US
dc.publisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/boneen_US
dc.relation.ispartofBoneen_US
dc.rightsBone. Copyright © Elsevier Inc.-
dc.subjectBone mineral density (BMD)-
dc.subjectEstrogen receptor (ER)-
dc.subjectSouthern Chinese women-
dc.subject.meshAdulten_US
dc.subject.meshAgeden_US
dc.subject.meshAnalysis Of Varianceen_US
dc.subject.meshBone Density - Geneticsen_US
dc.subject.meshEstrogen Receptor Betaen_US
dc.subject.meshFemaleen_US
dc.subject.meshGenetic Markers - Geneticsen_US
dc.subject.meshHong Kongen_US
dc.subject.meshHumansen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshPolymorphism, Genetic - Geneticsen_US
dc.subject.meshPostmenopause - Geneticsen_US
dc.subject.meshPremenopause - Geneticsen_US
dc.subject.meshReceptors, Estrogen - Geneticsen_US
dc.subject.meshTerminal Repeat Sequences - Geneticsen_US
dc.titleEstrogen receptor β gene polymorphisms are associated with higher bone mineral density in premenopausal, but not postmenopausal southern Chinese womenen_US
dc.typeArticleen_US
dc.identifier.emailLuk, KDK:hcm21000@hku.hken_US
dc.identifier.emailKung, AWC:awckung@hku.hken_US
dc.identifier.authorityLuk, KDK=rp00333en_US
dc.identifier.authorityKung, AWC=rp00368en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1016/S8756-3282(02)00827-Xen_US
dc.identifier.pmid12151079-
dc.identifier.scopuseid_2-s2.0-0036021054en_US
dc.identifier.hkuros78722-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0036021054&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume31en_US
dc.identifier.issue2en_US
dc.identifier.spage276en_US
dc.identifier.epage281en_US
dc.identifier.isiWOS:000177575600002-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridLau, HHL=7201497775en_US
dc.identifier.scopusauthoridHo, AYY=7402675209en_US
dc.identifier.scopusauthoridLuk, KDK=7201921573en_US
dc.identifier.scopusauthoridKung, AWC=7102322339en_US

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