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Article: Clonal marrow abnormalities after azathioprine and sulfasalazine exposure in Crohn's disease: A cautionary tale

TitleClonal marrow abnormalities after azathioprine and sulfasalazine exposure in Crohn's disease: A cautionary tale
Authors
Issue Date2002
PublisherInforma Healthcare. The Journal's web site is located at http://informahealthcare.com/loi/lal
Citation
Leukemia And Lymphoma, 2002, v. 43 n. 8, p. 1679-1681 How to Cite?
AbstractWe report a patient with longstanding Crohn's disease (CD) developing recurrent sepsis and impaired neutrophil function tests. His inflammatory bowel disease was controlled with local steroids and sulfasalazine with only short exposure to azathioprine. His blood counts remained within normal range, but the marrow showed mild dysplasia. Repeated cytogenetic examinations revealed trisomies 8 and 9, which are typical for therapy related myelodysplasia. Fluorescent in situ hybridization (FISH) study showed stable persistent trisomies, confined to the myeloid lineage, one year after discontinuation of sulfasalazine. The long-term use of immunodulating agents in patients with CD is not without risks, and early therapy related myelodysplasia might not be easily detected by blood count and morphology assessment alone.
Persistent Identifierhttp://hdl.handle.net/10722/162569
ISSN
2015 Impact Factor: 3.093
2015 SCImago Journal Rankings: 1.202
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorAu, WYen_US
dc.contributor.authorYuen, MFen_US
dc.contributor.authorLai, KCen_US
dc.contributor.authorWan, TSKen_US
dc.contributor.authorMa, SKen_US
dc.date.accessioned2012-09-05T05:21:17Z-
dc.date.available2012-09-05T05:21:17Z-
dc.date.issued2002en_US
dc.identifier.citationLeukemia And Lymphoma, 2002, v. 43 n. 8, p. 1679-1681en_US
dc.identifier.issn1042-8194en_US
dc.identifier.urihttp://hdl.handle.net/10722/162569-
dc.description.abstractWe report a patient with longstanding Crohn's disease (CD) developing recurrent sepsis and impaired neutrophil function tests. His inflammatory bowel disease was controlled with local steroids and sulfasalazine with only short exposure to azathioprine. His blood counts remained within normal range, but the marrow showed mild dysplasia. Repeated cytogenetic examinations revealed trisomies 8 and 9, which are typical for therapy related myelodysplasia. Fluorescent in situ hybridization (FISH) study showed stable persistent trisomies, confined to the myeloid lineage, one year after discontinuation of sulfasalazine. The long-term use of immunodulating agents in patients with CD is not without risks, and early therapy related myelodysplasia might not be easily detected by blood count and morphology assessment alone.en_US
dc.languageengen_US
dc.publisherInforma Healthcare. The Journal's web site is located at http://informahealthcare.com/loi/lalen_US
dc.relation.ispartofLeukemia and Lymphomaen_US
dc.subject.meshAdulten_US
dc.subject.meshAzathioprine - Administration & Dosage - Adverse Effectsen_US
dc.subject.meshCrohn Disease - Complications - Drug Therapyen_US
dc.subject.meshHumansen_US
dc.subject.meshMaleen_US
dc.subject.meshMyelodysplastic Syndromes - Etiology - Geneticsen_US
dc.subject.meshNeutrophils - Immunologyen_US
dc.subject.meshSulfasalazine - Administration & Dosageen_US
dc.subject.meshTrisomyen_US
dc.titleClonal marrow abnormalities after azathioprine and sulfasalazine exposure in Crohn's disease: A cautionary taleen_US
dc.typeArticleen_US
dc.identifier.emailYuen, MF:mfyuen@hkucc.hku.hken_US
dc.identifier.authorityYuen, MF=rp00479en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1080/1042819021000003027en_US
dc.identifier.pmid12400612en_US
dc.identifier.scopuseid_2-s2.0-0036020982en_US
dc.identifier.hkuros77867-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0036020982&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume43en_US
dc.identifier.issue8en_US
dc.identifier.spage1679en_US
dc.identifier.epage1681en_US
dc.identifier.isiWOS:000177223900020-
dc.publisher.placeUnited Kingdomen_US
dc.identifier.scopusauthoridAu, WY=7202383089en_US
dc.identifier.scopusauthoridYuen, MF=7102031955en_US
dc.identifier.scopusauthoridLai, KC=7402135595en_US
dc.identifier.scopusauthoridWan, TSK=25623981600en_US
dc.identifier.scopusauthoridMa, SK=9042504200en_US

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