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Article: Inverse association between cyclooxygenase-2 overexpression and microsatellite instability in gastric cancer

TitleInverse association between cyclooxygenase-2 overexpression and microsatellite instability in gastric cancer
Authors
Issue Date2001
PublisherElsevier Ireland Ltd. The Journal's web site is located at http://www.elsevier.com/locate/canlet
Citation
Cancer Letters, 2001, v. 168 n. 2, p. 133-140 How to Cite?
AbstractThis study examined the association between cyclooxygenase-2 (COX-2) overexpression and microsatellite instability (MSI) in gastric cancer. COX-2 expression was assessed by immunohistochemistry and scored in a semi-quantitative manner whereas MSI status was characterized by nine microsatellite markers. The clinicopathological features of cancers including survival data were analyzed. Of the 109 gastric cancers studied, COX-2 overexpression and high level of MSI (MSI-H) was detected in 64.2 and 22.0% cases respectively. Gastric tumors with MSI-H phenotypes had significantly lower level of COX-2 expression levels when compared to MSI-L and MSS tumors (P = 0.002). Moreover, COX-2 overexpression was associated with tumor invasion beyond submucosa (P = 0.045) and there was a trend favoring better survival in gastric cancers without COX-2 overexpression (P = 0.07). The results from this study suggest that gastric cancer with microsatellite instability or COX-2 overexpression present with diverse clinicopathological features. © 2001 Elsevier Science Ireland Ltd.
Persistent Identifierhttp://hdl.handle.net/10722/162561
ISSN
2015 Impact Factor: 5.992
2015 SCImago Journal Rankings: 2.331
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorLee, TLen_US
dc.contributor.authorLeung, WKen_US
dc.contributor.authorLau, JYWen_US
dc.contributor.authorTong, JHMen_US
dc.contributor.authorNg, EKWen_US
dc.contributor.authorChan, FKLen_US
dc.contributor.authorChung, SCSydneyen_US
dc.contributor.authorSung, JJYen_US
dc.contributor.authorTo, KFen_US
dc.date.accessioned2012-09-05T05:21:10Z-
dc.date.available2012-09-05T05:21:10Z-
dc.date.issued2001en_US
dc.identifier.citationCancer Letters, 2001, v. 168 n. 2, p. 133-140en_US
dc.identifier.issn0304-3835en_US
dc.identifier.urihttp://hdl.handle.net/10722/162561-
dc.description.abstractThis study examined the association between cyclooxygenase-2 (COX-2) overexpression and microsatellite instability (MSI) in gastric cancer. COX-2 expression was assessed by immunohistochemistry and scored in a semi-quantitative manner whereas MSI status was characterized by nine microsatellite markers. The clinicopathological features of cancers including survival data were analyzed. Of the 109 gastric cancers studied, COX-2 overexpression and high level of MSI (MSI-H) was detected in 64.2 and 22.0% cases respectively. Gastric tumors with MSI-H phenotypes had significantly lower level of COX-2 expression levels when compared to MSI-L and MSS tumors (P = 0.002). Moreover, COX-2 overexpression was associated with tumor invasion beyond submucosa (P = 0.045) and there was a trend favoring better survival in gastric cancers without COX-2 overexpression (P = 0.07). The results from this study suggest that gastric cancer with microsatellite instability or COX-2 overexpression present with diverse clinicopathological features. © 2001 Elsevier Science Ireland Ltd.en_US
dc.languageengen_US
dc.publisherElsevier Ireland Ltd. The Journal's web site is located at http://www.elsevier.com/locate/canleten_US
dc.relation.ispartofCancer Lettersen_US
dc.subject.meshCohort Studiesen_US
dc.subject.meshCyclooxygenase 2en_US
dc.subject.meshFemaleen_US
dc.subject.meshHumansen_US
dc.subject.meshIsoenzymes - Biosynthesisen_US
dc.subject.meshMaleen_US
dc.subject.meshMembrane Proteinsen_US
dc.subject.meshMicrosatellite Repeats - Geneticsen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshProstaglandin-Endoperoxide Synthases - Biosynthesisen_US
dc.subject.meshStomach Neoplasms - Enzymology - Genetics - Pathologyen_US
dc.subject.meshSurvival Rateen_US
dc.titleInverse association between cyclooxygenase-2 overexpression and microsatellite instability in gastric canceren_US
dc.typeArticleen_US
dc.identifier.emailLeung, WK:waikleung@hku.hken_US
dc.identifier.authorityLeung, WK=rp01479en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1016/S0304-3835(01)00527-4en_US
dc.identifier.pmid11403917-
dc.identifier.scopuseid_2-s2.0-0035954827en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0035954827&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume168en_US
dc.identifier.issue2en_US
dc.identifier.spage133en_US
dc.identifier.epage140en_US
dc.identifier.isiWOS:000169709400004-
dc.publisher.placeIrelanden_US
dc.identifier.scopusauthoridLee, TL=35292432600en_US
dc.identifier.scopusauthoridLeung, WK=7201504523en_US
dc.identifier.scopusauthoridLau, JYW=13907867100en_US
dc.identifier.scopusauthoridTong, JHM=7202724564en_US
dc.identifier.scopusauthoridNg, EKW=7201647539en_US
dc.identifier.scopusauthoridChan, FKL=7202586434en_US
dc.identifier.scopusauthoridChung, SCSydney=19642462800en_US
dc.identifier.scopusauthoridSung, JJY=35405352400en_US
dc.identifier.scopusauthoridTo, KF=7101911940en_US

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