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Article: Positive regulation of T cell activation and integrin adhesion by the adapter Fyb/Slap

TitlePositive regulation of T cell activation and integrin adhesion by the adapter Fyb/Slap
Authors
Issue Date2001
PublisherAmerican Association for the Advancement of Science. The Journal's web site is located at http://sciencemag.org
Citation
Science, 2001, v. 293 n. 5538, p. 2260-2263 How to Cite?
AbstractThe molecular adapter Fyb/Slap regulates signaling downstream of the T cell receptor (TCR), but whether it plays a positive or negative role is controversial. We demonstrate that Fyb/Slap-deficient T cells exhibit defective proliferation and cytokine production in response to TCR stimulation. Fyb/Slap is also required in vivo for T cell-dependent immune responses. Functionally, Fyb/Slap has no apparent role in the activation of known TCR signaling pathways, F-actin polymerization, or TCR clustering. Rather, Fyb/Slap regulates TCR-induced integrin clustering and adhesion. Thus, Fyb/Slap is the first molecular adapter to be identified that couples TCR stimulation to the avidity modulation of integrins governing T cell adhesion.
Persistent Identifierhttp://hdl.handle.net/10722/162560
ISSN
2015 Impact Factor: 34.661
2015 SCImago Journal Rankings: 13.217
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorGriffiths, EKen_US
dc.contributor.authorKrawczyk, Cen_US
dc.contributor.authorKong, YYen_US
dc.contributor.authorRaab, Men_US
dc.contributor.authorHyduk, SJen_US
dc.contributor.authorBouchard, Den_US
dc.contributor.authorChan, VSen_US
dc.contributor.authorKozieradzki, Ien_US
dc.contributor.authorOliveiraDosSantos, AJen_US
dc.contributor.authorWakeham, Aen_US
dc.contributor.authorOhashi, PSen_US
dc.contributor.authorCybulsky, MIen_US
dc.contributor.authorRudd, CEen_US
dc.contributor.authorPenninger, JMen_US
dc.date.accessioned2012-09-05T05:21:09Z-
dc.date.available2012-09-05T05:21:09Z-
dc.date.issued2001en_US
dc.identifier.citationScience, 2001, v. 293 n. 5538, p. 2260-2263en_US
dc.identifier.issn0036-8075en_US
dc.identifier.urihttp://hdl.handle.net/10722/162560-
dc.description.abstractThe molecular adapter Fyb/Slap regulates signaling downstream of the T cell receptor (TCR), but whether it plays a positive or negative role is controversial. We demonstrate that Fyb/Slap-deficient T cells exhibit defective proliferation and cytokine production in response to TCR stimulation. Fyb/Slap is also required in vivo for T cell-dependent immune responses. Functionally, Fyb/Slap has no apparent role in the activation of known TCR signaling pathways, F-actin polymerization, or TCR clustering. Rather, Fyb/Slap regulates TCR-induced integrin clustering and adhesion. Thus, Fyb/Slap is the first molecular adapter to be identified that couples TCR stimulation to the avidity modulation of integrins governing T cell adhesion.en_US
dc.languageengen_US
dc.publisherAmerican Association for the Advancement of Science. The Journal's web site is located at http://sciencemag.orgen_US
dc.relation.ispartofScienceen_US
dc.subject.meshActins - Metabolismen_US
dc.subject.meshAdaptor Proteins, Signal Transducingen_US
dc.subject.meshAnimalsen_US
dc.subject.meshAntigens, Cd - Metabolismen_US
dc.subject.meshAntigens, Cd3 - Metabolismen_US
dc.subject.meshAntigens, Differentiation, T-Lymphocyte - Metabolismen_US
dc.subject.meshB-Lymphocytes - Immunologyen_US
dc.subject.meshCarrier Proteins - Genetics - Physiologyen_US
dc.subject.meshCell Adhesionen_US
dc.subject.meshCell Adhesion Molecules - Metabolismen_US
dc.subject.meshChimeraen_US
dc.subject.meshGene Targetingen_US
dc.subject.meshHumansen_US
dc.subject.meshImmunizationen_US
dc.subject.meshImmunoglobulin G - Biosynthesisen_US
dc.subject.meshIntegrins - Metabolismen_US
dc.subject.meshIntercellular Adhesion Molecule-1 - Metabolismen_US
dc.subject.meshInterferon-Gamma - Biosynthesisen_US
dc.subject.meshInterleukin-2 - Biosynthesis - Pharmacologyen_US
dc.subject.meshLectins, C-Typeen_US
dc.subject.meshLymphocyte Activationen_US
dc.subject.meshLymphocyte Function-Associated Antigen-1 - Metabolismen_US
dc.subject.meshMiceen_US
dc.subject.meshPhosphoproteins - Genetics - Physiologyen_US
dc.subject.meshReceptors, Antigen, T-Cell - Immunology - Metabolismen_US
dc.subject.meshReceptors, Interleukin-2 - Metabolismen_US
dc.subject.meshRecombinant Proteins - Metabolismen_US
dc.subject.meshSignal Transductionen_US
dc.subject.meshT-Lymphocytes - Immunology - Metabolism - Physiologyen_US
dc.titlePositive regulation of T cell activation and integrin adhesion by the adapter Fyb/Slapen_US
dc.typeArticleen_US
dc.identifier.emailChan, VS:sfvchan@hku.hken_US
dc.identifier.authorityChan, VS=rp01459en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1126/science.1063397en_US
dc.identifier.pmid11567140-
dc.identifier.scopuseid_2-s2.0-0035929128en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0035929128&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume293en_US
dc.identifier.issue5538en_US
dc.identifier.spage2260en_US
dc.identifier.epage2263en_US
dc.identifier.isiWOS:000171139400045-
dc.publisher.placeUnited Statesen_US
dc.identifier.f10001001925-
dc.identifier.scopusauthoridGriffiths, EK=7103161860en_US
dc.identifier.scopusauthoridKrawczyk, C=7004516409en_US
dc.identifier.scopusauthoridKong, YY=7201616022en_US
dc.identifier.scopusauthoridRaab, M=7006822868en_US
dc.identifier.scopusauthoridHyduk, SJ=6603324928en_US
dc.identifier.scopusauthoridBouchard, D=8747658200en_US
dc.identifier.scopusauthoridChan, VS=35200370000en_US
dc.identifier.scopusauthoridKozieradzki, I=6701469449en_US
dc.identifier.scopusauthoridOliveiradosSantos, AJ=6701915241en_US
dc.identifier.scopusauthoridWakeham, A=7003944156en_US
dc.identifier.scopusauthoridOhashi, PS=7006493798en_US
dc.identifier.scopusauthoridCybulsky, MI=7004433611en_US
dc.identifier.scopusauthoridRudd, CE=7102239460en_US
dc.identifier.scopusauthoridPenninger, JM=35419243000en_US
dc.identifier.citeulike7053909-

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