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Article: Risk of haematological malignancies in HLA-B27 carriers

TitleRisk of haematological malignancies in HLA-B27 carriers
Authors
Au, WYHawkins, BRCheng, NLie, AKWLiang, RKwong, YL
KeywordsAcute leukaemia
Ankylosing spondylitis
HLA B27
Issue Date2001
PublisherBlackwell Publishing Ltd. The Journal's web site is located at http://www.blackwellpublishing.com/journals/BJH
Citation
British Journal of Haematology, 2001, v. 115 n. 2, p. 320-322 How to Cite?
DOI: http://dx.doi.org/10.1046/j.1365-2141.2001.03114.x
AbstractHuman leucocyte antigen (HLA)-B27 carriers are predisposed to inflammatory and autoimmune diseases. Among 1137 patients with haematological diseases, 59 HLA-B27 carriers were identified. Compared with 18 774 volunteers, the incidence of HLA-B27 was increased in patients with acute leukaemia (relative risk RR = 1.67, P = 0.002), for both acute myeloid leukaemia (AML) (RR) = 1.67, P = 0.007) and acute lymphoblastic leukaemia (ALL) (RR = 1.68, P = 0.094). Of all the HLA-B27 carriers, four patients had ankylosing spondylitis (AS), all with lymphoid malignancies (three ALL, one Hodgkin's disease), whereas no HLA-B27 carriers with myeloid leukaemia had AS symptoms (P = 0.006). This suggests that HLA-B27 carriers may have an increased risk of acute leukaemia and those with concomitant AS may be predisposed to lymphoid malignancies.
Persistent Identifierhttp://hdl.handle.net/10722/162549
ISSN
0007-1048
2023 Impact Factor: 5.1
2023 SCImago Journal Rankings: 1.574
ISI Accession Number ID
WOS:000172403300014
References
References in Scopus

 

DC FieldValueLanguage
dc.contributor.authorAu, WYen_US
dc.contributor.authorHawkins, BRen_US
dc.contributor.authorCheng, Nen_US
dc.contributor.authorLie, AKWen_US
dc.contributor.authorLiang, Ren_US
dc.contributor.authorKwong, YLen_US
dc.date.accessioned2012-09-05T05:20:59Z-
dc.date.available2012-09-05T05:20:59Z-
dc.date.issued2001en_US
dc.identifier.citationBritish Journal of Haematology, 2001, v. 115 n. 2, p. 320-322en_US
dc.identifier.issn0007-1048en_US
dc.identifier.urihttp://hdl.handle.net/10722/162549-
dc.description.abstractHuman leucocyte antigen (HLA)-B27 carriers are predisposed to inflammatory and autoimmune diseases. Among 1137 patients with haematological diseases, 59 HLA-B27 carriers were identified. Compared with 18 774 volunteers, the incidence of HLA-B27 was increased in patients with acute leukaemia (relative risk RR = 1.67, P = 0.002), for both acute myeloid leukaemia (AML) (RR) = 1.67, P = 0.007) and acute lymphoblastic leukaemia (ALL) (RR = 1.68, P = 0.094). Of all the HLA-B27 carriers, four patients had ankylosing spondylitis (AS), all with lymphoid malignancies (three ALL, one Hodgkin's disease), whereas no HLA-B27 carriers with myeloid leukaemia had AS symptoms (P = 0.006). This suggests that HLA-B27 carriers may have an increased risk of acute leukaemia and those with concomitant AS may be predisposed to lymphoid malignancies.en_US
dc.languageengen_US
dc.publisherBlackwell Publishing Ltd. The Journal's web site is located at http://www.blackwellpublishing.com/journals/BJHen_US
dc.relation.ispartofBritish Journal of Haematologyen_US
dc.rightsBritish Journal of Haematology. Copyright © Blackwell Publishing Ltd.-
dc.subjectAcute leukaemia-
dc.subjectAnkylosing spondylitis-
dc.subjectHLA B27-
dc.subject.meshAcute Diseaseen_US
dc.subject.meshAdolescenten_US
dc.subject.meshAdulten_US
dc.subject.meshFemaleen_US
dc.subject.meshGenetic Predisposition To Diseaseen_US
dc.subject.meshHla-B27 Antigenen_US
dc.subject.meshHematologic Neoplasms - Geneticsen_US
dc.subject.meshHistocompatibility Testingen_US
dc.subject.meshHumansen_US
dc.subject.meshLeukemia - Geneticsen_US
dc.subject.meshMaleen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshRisk Assessmenten_US
dc.subject.meshSpondylitis, Ankylosing - Geneticsen_US
dc.titleRisk of haematological malignancies in HLA-B27 carriersen_US
dc.typeArticleen_US
dc.identifier.emailLiang, R:rliang@hku.hken_US
dc.identifier.emailKwong, YL:ylkwong@hku.hken_US
dc.identifier.authorityLiang, R=rp00345en_US
dc.identifier.authorityKwong, YL=rp00358en_US
dc.description.naturelink_to_OA_fulltexten_US
dc.identifier.doi10.1046/j.1365-2141.2001.03114.xen_US
dc.identifier.pmid11703328en_US
dc.identifier.scopuseid_2-s2.0-0035725105en_US
dc.identifier.hkuros67010-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0035725105&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume115en_US
dc.identifier.issue2en_US
dc.identifier.spage320en_US
dc.identifier.epage322en_US
dc.identifier.isiWOS:000172403300014-
dc.publisher.placeUnited Kingdomen_US
dc.identifier.scopusauthoridAu, WY=7202383089en_US
dc.identifier.scopusauthoridHawkins, BR=35944486200en_US
dc.identifier.scopusauthoridCheng, N=36749006300en_US
dc.identifier.scopusauthoridLie, AKW=24284842400en_US
dc.identifier.scopusauthoridLiang, R=26643224900en_US
dc.identifier.scopusauthoridKwong, YL=7102818954en_US
dc.identifier.issnl0007-1048-

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