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- Publisher Website: 10.1046/j.1365-2036.2001.01132.x
- Scopus: eid_2-s2.0-0035659488
- PMID: 11736722
- WOS: WOS:000172788300010
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Article: Dysfunction of oesophageal motility in Helicobacter pylori-infected patients with reflux oesophagitis
Title | Dysfunction of oesophageal motility in Helicobacter pylori-infected patients with reflux oesophagitis |
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Authors | |
Issue Date | 2001 |
Publisher | Blackwell Publishing Ltd. The Journal's web site is located at http://www.blackwellpublishing.com/journals/APT |
Citation | Alimentary Pharmacology And Therapeutics, 2001, v. 15 n. 12, p. 1913-1919 How to Cite? |
Abstract | Background: Helicobacter pylori infection has been suggested to be protective against gastro-oesophageal reflux disease. However, a significant proportion of patients with gastro-oesophageal reflux disease are infected by H. pylori. Aim: To study oesophageal motor function in H. pylori-infected patients with reflux oesophagitis. Methods: Patients with erosive reflux oesophagitis were recruited prospectively for stationary oesophageal manometry and 24-h ambulatory oesophageal pH monitoring. H. pylori status was determined by biopsy urease test. Non-reflux volunteers were recruited as controls. Results: Seventy-four patients with erosive oesophagitis (34 H. pylori-positive, 40 H. pylori-negative) and 48 non-reflux patient controls (22 H. pylori-positive, 26 H. pylori-negative) were recruited. There was no difference in severity of oesophagitis (median grade, 1; P = 0.53) or oesophageal acid exposure (total percentage time oesophageal pH < 4, 7.6% vs. 6.8%; P = 0.57) between H. pylori-positive and H. pylori-negative groups. Compared to H. pylori-negative patients, H. pylori-positive patients had significantly lower basal lower oesophageal sphincter pressure (12.2 mmHg vs. 15.3 mmHg; P = 0.03) and amplitude of distal peristalsis (56.9 mmHg vs. 68.4 mmHg: P = 0.03). Ineffective oesophageal motility (14% vs. 7%; P = 0.02) and failed oesophageal peristalsis were also significantly more prevalent in H. pylori-positive patients. Conclusions: Among patients with a similar degree of reflux oesophagitis, H. pylori-infected patients have more severe oesophageal dysmotility and lower oesophageal sphincter dysfunction. Oesophageal motor dysfunction probably plays a dominant role in the development of gastro-oesophageal reflux disease in patients with H. pylori infection. |
Persistent Identifier | http://hdl.handle.net/10722/162543 |
ISSN | 2023 Impact Factor: 6.6 2023 SCImago Journal Rankings: 2.794 |
ISI Accession Number ID | |
References |
DC Field | Value | Language |
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dc.contributor.author | Wu, JCY | en_US |
dc.contributor.author | Lai, ACW | en_US |
dc.contributor.author | Wong, SKH | en_US |
dc.contributor.author | Chan, FKL | en_US |
dc.contributor.author | Leung, WK | en_US |
dc.contributor.author | Sung, JJY | en_US |
dc.date.accessioned | 2012-09-05T05:20:55Z | - |
dc.date.available | 2012-09-05T05:20:55Z | - |
dc.date.issued | 2001 | en_US |
dc.identifier.citation | Alimentary Pharmacology And Therapeutics, 2001, v. 15 n. 12, p. 1913-1919 | en_US |
dc.identifier.issn | 0269-2813 | en_US |
dc.identifier.uri | http://hdl.handle.net/10722/162543 | - |
dc.description.abstract | Background: Helicobacter pylori infection has been suggested to be protective against gastro-oesophageal reflux disease. However, a significant proportion of patients with gastro-oesophageal reflux disease are infected by H. pylori. Aim: To study oesophageal motor function in H. pylori-infected patients with reflux oesophagitis. Methods: Patients with erosive reflux oesophagitis were recruited prospectively for stationary oesophageal manometry and 24-h ambulatory oesophageal pH monitoring. H. pylori status was determined by biopsy urease test. Non-reflux volunteers were recruited as controls. Results: Seventy-four patients with erosive oesophagitis (34 H. pylori-positive, 40 H. pylori-negative) and 48 non-reflux patient controls (22 H. pylori-positive, 26 H. pylori-negative) were recruited. There was no difference in severity of oesophagitis (median grade, 1; P = 0.53) or oesophageal acid exposure (total percentage time oesophageal pH < 4, 7.6% vs. 6.8%; P = 0.57) between H. pylori-positive and H. pylori-negative groups. Compared to H. pylori-negative patients, H. pylori-positive patients had significantly lower basal lower oesophageal sphincter pressure (12.2 mmHg vs. 15.3 mmHg; P = 0.03) and amplitude of distal peristalsis (56.9 mmHg vs. 68.4 mmHg: P = 0.03). Ineffective oesophageal motility (14% vs. 7%; P = 0.02) and failed oesophageal peristalsis were also significantly more prevalent in H. pylori-positive patients. Conclusions: Among patients with a similar degree of reflux oesophagitis, H. pylori-infected patients have more severe oesophageal dysmotility and lower oesophageal sphincter dysfunction. Oesophageal motor dysfunction probably plays a dominant role in the development of gastro-oesophageal reflux disease in patients with H. pylori infection. | en_US |
dc.language | eng | en_US |
dc.publisher | Blackwell Publishing Ltd. The Journal's web site is located at http://www.blackwellpublishing.com/journals/APT | en_US |
dc.relation.ispartof | Alimentary Pharmacology and Therapeutics | en_US |
dc.subject.mesh | Adult | en_US |
dc.subject.mesh | Aged | en_US |
dc.subject.mesh | Esophagitis, Peptic - Microbiology - Physiopathology | en_US |
dc.subject.mesh | Female | en_US |
dc.subject.mesh | Gastritis - Microbiology - Physiopathology | en_US |
dc.subject.mesh | Gastroesophageal Reflux - Microbiology - Physiopathology | en_US |
dc.subject.mesh | Helicobacter Infections - Microbiology - Physiopathology | en_US |
dc.subject.mesh | Helicobacter Pylori | en_US |
dc.subject.mesh | Humans | en_US |
dc.subject.mesh | Male | en_US |
dc.subject.mesh | Middle Aged | en_US |
dc.title | Dysfunction of oesophageal motility in Helicobacter pylori-infected patients with reflux oesophagitis | en_US |
dc.type | Article | en_US |
dc.identifier.email | Leung, WK:waikleung@hku.hk | en_US |
dc.identifier.authority | Leung, WK=rp01479 | en_US |
dc.description.nature | link_to_subscribed_fulltext | en_US |
dc.identifier.doi | 10.1046/j.1365-2036.2001.01132.x | en_US |
dc.identifier.pmid | 11736722 | - |
dc.identifier.scopus | eid_2-s2.0-0035659488 | en_US |
dc.relation.references | http://www.scopus.com/mlt/select.url?eid=2-s2.0-0035659488&selection=ref&src=s&origin=recordpage | en_US |
dc.identifier.volume | 15 | en_US |
dc.identifier.issue | 12 | en_US |
dc.identifier.spage | 1913 | en_US |
dc.identifier.epage | 1919 | en_US |
dc.identifier.isi | WOS:000172788300010 | - |
dc.publisher.place | United Kingdom | en_US |
dc.identifier.scopusauthorid | Wu, JCY=7409253910 | en_US |
dc.identifier.scopusauthorid | Lai, ACW=7102226209 | en_US |
dc.identifier.scopusauthorid | Wong, SKH=24345849900 | en_US |
dc.identifier.scopusauthorid | Chan, FKL=7202586434 | en_US |
dc.identifier.scopusauthorid | Leung, WK=7201504523 | en_US |
dc.identifier.scopusauthorid | Sung, JJY=35405352400 | en_US |
dc.identifier.issnl | 0269-2813 | - |