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Article: Induction of unspliced c-fos messenger RNA in rodent brain by kainic acid and lipopolysaccharide

TitleInduction of unspliced c-fos messenger RNA in rodent brain by kainic acid and lipopolysaccharide
Authors
Issue Date2001
PublisherElsevier Ireland Ltd. The Journal's web site is located at http://www.elsevier.com/locate/neulet
Citation
Neuroscience Letters, 2001, v. 305 n. 1, p. 17-20 How to Cite?
AbstractThe c-fos transcriptional factor forms an activator protein-1 (AP-1) complex with proteins from the Jun family, which plays an important role in the central nervous system. The responses of AP-1 transcriptional factors induced by kainic acid (KA) treatment have been well studied, although the transcriptional regulation of these KA-induced factors has not been clearly characterized. To investigate the role of different stimuli in controlling of the splicing of c-fos mRNA, we performed reverse transcriptional polymerase chain reaction. The results showed that spliced and unspliced c-fos is present in rat brain following KA treatment and in lipopolysaccharide (LPS)-treated primary mouse cortical brain cell cultures. Furthermore, tyrosine kinase and protein phosphatase inhibitors alter the preponderance of c-fos transcripts following LPS treatment. © 2001 Elsevier Science Ireland Ltd.
Persistent Identifierhttp://hdl.handle.net/10722/162528
ISSN
2015 Impact Factor: 2.107
2015 SCImago Journal Rankings: 1.035
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorFeng, Zen_US
dc.contributor.authorKong, LYen_US
dc.contributor.authorQi, Qen_US
dc.contributor.authorHo, SLen_US
dc.contributor.authorTiao, Nen_US
dc.contributor.authorBing, Gen_US
dc.contributor.authorHan, YFen_US
dc.date.accessioned2012-09-05T05:20:48Z-
dc.date.available2012-09-05T05:20:48Z-
dc.date.issued2001en_US
dc.identifier.citationNeuroscience Letters, 2001, v. 305 n. 1, p. 17-20en_US
dc.identifier.issn0304-3940en_US
dc.identifier.urihttp://hdl.handle.net/10722/162528-
dc.description.abstractThe c-fos transcriptional factor forms an activator protein-1 (AP-1) complex with proteins from the Jun family, which plays an important role in the central nervous system. The responses of AP-1 transcriptional factors induced by kainic acid (KA) treatment have been well studied, although the transcriptional regulation of these KA-induced factors has not been clearly characterized. To investigate the role of different stimuli in controlling of the splicing of c-fos mRNA, we performed reverse transcriptional polymerase chain reaction. The results showed that spliced and unspliced c-fos is present in rat brain following KA treatment and in lipopolysaccharide (LPS)-treated primary mouse cortical brain cell cultures. Furthermore, tyrosine kinase and protein phosphatase inhibitors alter the preponderance of c-fos transcripts following LPS treatment. © 2001 Elsevier Science Ireland Ltd.en_US
dc.languageengen_US
dc.publisherElsevier Ireland Ltd. The Journal's web site is located at http://www.elsevier.com/locate/neuleten_US
dc.relation.ispartofNeuroscience Lettersen_US
dc.subject.meshAnimalsen_US
dc.subject.meshBase Sequence - Geneticsen_US
dc.subject.meshBrain - Drug Effects - Metabolismen_US
dc.subject.meshDna, Recombinanten_US
dc.subject.meshExcitatory Amino Acid Agonists - Pharmacologyen_US
dc.subject.meshKainic Acid - Pharmacologyen_US
dc.subject.meshLipopolysaccharides - Pharmacologyen_US
dc.subject.meshMaleen_US
dc.subject.meshMolecular Sequence Dataen_US
dc.subject.meshProto-Oncogene Proteins C-Fos - Geneticsen_US
dc.subject.meshRna, Messenger - Metabolismen_US
dc.subject.meshRatsen_US
dc.subject.meshRats, Inbred F344en_US
dc.subject.meshReverse Transcriptase Polymerase Chain Reactionen_US
dc.titleInduction of unspliced c-fos messenger RNA in rodent brain by kainic acid and lipopolysaccharideen_US
dc.typeArticleen_US
dc.identifier.emailHo, SL:slho@hku.hken_US
dc.identifier.authorityHo, SL=rp00240en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1016/S0304-3940(01)01793-1en_US
dc.identifier.pmid11356297-
dc.identifier.scopuseid_2-s2.0-0035371488en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0035371488&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume305en_US
dc.identifier.issue1en_US
dc.identifier.spage17en_US
dc.identifier.epage20en_US
dc.identifier.isiWOS:000169118000005-
dc.publisher.placeIrelanden_US
dc.identifier.scopusauthoridFeng, Z=7403442974en_US
dc.identifier.scopusauthoridKong, LY=25934641600en_US
dc.identifier.scopusauthoridQi, Q=35819637700en_US
dc.identifier.scopusauthoridHo, SL=25959633500en_US
dc.identifier.scopusauthoridTiao, N=7801575007en_US
dc.identifier.scopusauthoridBing, G=7004276368en_US
dc.identifier.scopusauthoridHan, YF=37036722900en_US

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