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Article: Rearrangement of the myeloid-lymphoid leukaemia gene in Hong Kong Chinese children with acute leukaemia.

TitleRearrangement of the myeloid-lymphoid leukaemia gene in Hong Kong Chinese children with acute leukaemia.
Authors
Issue Date2001
PublisherHong Kong Medical Association. The Journal's web site is located at http://www.hkmj.org/resources/supp.html
Citation
Hong Kong Medical Journal = Xianggang Yi Xue Za Zhi / Hong Kong Academy Of Medicine, 2001, v. 7 n. 1, p. 9-14 How to Cite?
AbstractOBJECTIVE: To determine the frequency of rearrangement of the myeloid-lymphoid leukaemia gene in acute leukaemia in Hong Kong Chinese children. DESIGN: Immunophenotyping, cytogenetic, and molecular analysis. SETTING: Regional hospital, Hong Kong. PARTICIPANTS: Bone marrow or peripheral blood samples were taken from 27 children aged 16 years or younger with acute leukaemia, from September 1995 through February 1998. MAIN OUTCOME MEASURES: Gene rearrangement was analysed by Southern blotting of HindIII digestion products of mononuclear cell DNA, followed by hybridisation with the myeloid-lymphoid leukaemia P/S4 probe. Nested reverse transcription-polymerase chain reaction analysis was performed to detect and characterise duplication of the myeloid-lymphoid leukaemia gene. RESULTS: Only one (4%) of 23 children whose marrow or peripheral blood samples contained adequate material for genetic study showed rearrangement in the myeloid-lymphoid leukaemia gene. No children were positive for partial tandem duplication of the myeloid-lymphoid leukaemia gene. CONCLUSION: Myeloid-lymphoid leukaemia gene rearrangement is rare in Hong Kong Chinese children with acute leukaemia.
Persistent Identifierhttp://hdl.handle.net/10722/162522
ISSN
2015 Impact Factor: 0.887
2015 SCImago Journal Rankings: 0.279

 

DC FieldValueLanguage
dc.contributor.authorLit, BMen_US
dc.contributor.authorWong, KFen_US
dc.contributor.authorKwong, YLen_US
dc.date.accessioned2012-09-05T05:20:44Z-
dc.date.available2012-09-05T05:20:44Z-
dc.date.issued2001en_US
dc.identifier.citationHong Kong Medical Journal = Xianggang Yi Xue Za Zhi / Hong Kong Academy Of Medicine, 2001, v. 7 n. 1, p. 9-14en_US
dc.identifier.issn1024-2708en_US
dc.identifier.urihttp://hdl.handle.net/10722/162522-
dc.description.abstractOBJECTIVE: To determine the frequency of rearrangement of the myeloid-lymphoid leukaemia gene in acute leukaemia in Hong Kong Chinese children. DESIGN: Immunophenotyping, cytogenetic, and molecular analysis. SETTING: Regional hospital, Hong Kong. PARTICIPANTS: Bone marrow or peripheral blood samples were taken from 27 children aged 16 years or younger with acute leukaemia, from September 1995 through February 1998. MAIN OUTCOME MEASURES: Gene rearrangement was analysed by Southern blotting of HindIII digestion products of mononuclear cell DNA, followed by hybridisation with the myeloid-lymphoid leukaemia P/S4 probe. Nested reverse transcription-polymerase chain reaction analysis was performed to detect and characterise duplication of the myeloid-lymphoid leukaemia gene. RESULTS: Only one (4%) of 23 children whose marrow or peripheral blood samples contained adequate material for genetic study showed rearrangement in the myeloid-lymphoid leukaemia gene. No children were positive for partial tandem duplication of the myeloid-lymphoid leukaemia gene. CONCLUSION: Myeloid-lymphoid leukaemia gene rearrangement is rare in Hong Kong Chinese children with acute leukaemia.en_US
dc.languageengen_US
dc.publisherHong Kong Medical Association. The Journal's web site is located at http://www.hkmj.org/resources/supp.htmlen_US
dc.relation.ispartofHong Kong medical journal = Xianggang yi xue za zhi / Hong Kong Academy of Medicineen_US
dc.subject.meshAdolescenten_US
dc.subject.meshChilden_US
dc.subject.meshChild, Preschoolen_US
dc.subject.meshDna-Binding Proteins - Geneticsen_US
dc.subject.meshFemaleen_US
dc.subject.meshGene Rearrangementen_US
dc.subject.meshHumansen_US
dc.subject.meshInfanten_US
dc.subject.meshInfant, Newbornen_US
dc.subject.meshLeukemia, Myeloid, Acute - Geneticsen_US
dc.subject.meshMaleen_US
dc.subject.meshMyeloid-Lymphoid Leukemia Proteinen_US
dc.subject.meshPrecursor Cell Lymphoblastic Leukemia-Lymphoma - Geneticsen_US
dc.subject.meshProto-Oncogenesen_US
dc.subject.meshReverse Transcriptase Polymerase Chain Reactionen_US
dc.subject.meshTranscription Factorsen_US
dc.titleRearrangement of the myeloid-lymphoid leukaemia gene in Hong Kong Chinese children with acute leukaemia.en_US
dc.typeArticleen_US
dc.identifier.emailKwong, YL:ylkwong@hku.hken_US
dc.identifier.authorityKwong, YL=rp00358en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.pmid11406670-
dc.identifier.scopuseid_2-s2.0-0035291149en_US
dc.identifier.volume7en_US
dc.identifier.issue1en_US
dc.identifier.spage9en_US
dc.identifier.epage14en_US
dc.publisher.placeHong Kongen_US
dc.identifier.scopusauthoridLit, BM=6507258783en_US
dc.identifier.scopusauthoridWong, KF=7404759860en_US
dc.identifier.scopusauthoridKwong, YL=7102818954en_US

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